Fellow eye effect of unilateral intravitreal bevacizumab injection in eyes with diabetic macular edema

Norrin treatment improves ganglion cell survival in an oxygen-induced retinopathy model of retinal ischemia

“…A fellow-eye effect has been demonstrated in multiple clinical studies involving anti-VEGF treatment of Diabetic Macular Edema (DME) (Avery et al, 2006; Bakbak et al, 2013; Hanhart et al, 2014). A possible fellow-eye therapeutic effect was also reported in diabetics, after bevacizumab injection (Avery et al, 2006).…”

In Vivo Characterization of Spontaneous Retinal Neovascularization in the Mouse Eye by Multifunctional Optical Coherence Tomography

“…This bilateral effect after unilateral injection was also reported in clinical studies and may be attributed to the systemic pharmacokinetics of the administered agent. 53,54 Recent work using popular anti-VEGF agents has demonstrated that aflibercept and bevacizumab have a stronger systemic exposure than ranibizumab. 55 This result is also in agreement with the findings published by Miki et al, 56 who observed a systemic effect of bevacizumab in a transgenic mouse model, but not with ranibizumab.…”

Single-eye trial of a topical carbonic anhydrase inhibitor versus intravitreal bevacizumab for the treatment of taxane drug-induced cystoid macula oedema

“…Finally, it is known that intravitreal bevacizumab is exported from the eye and significantly lowers serum vascular endothelial growth factor levels 20. It is possible that intravitreal bevacizumab had a therapeutic effect on the fellow eye, as has been reported in case series of bilateral diabetic macular oedema and in case reports of bilateral branch retinal vein occlusions and bilateral uveitis-related macular oedema 21. However, the contralateral bevacizumab treatment effect observed in our patient is eightfold smaller than the mean reduction in untreated eye CMT reported in previous research.…”