Feline injection-site sarcoma: Recurrence, tumour grading and surgical margin status evaluated using the three-dimensional histological technique

Giudice, Chiara; Stefanello, Damiano; Sala, M.; Cantatore, Matteo; Russo, F; Romussi, S.; Travetti, O.; Giancamillo, M. Di; Grieco, Valeria

doi:10.1016/j.tvjl.2009.07.019

Cited by 63 publications

(155 citation statements)

References 23 publications

Supporting

Mentioning

141

Contrasting

Unclassified

Order By: Relevance

“…Histologically, FISS may contain seldom large macrophages that display in the cytoplasm a blue to greyish material, most likely due to ingestion of adjuvant substances [20,21]. Such macrophages were observed in less than 50% of FISS [22,23,24]. No such macrophages were observed in our study.…”

Section: Discussioncontrasting

confidence: 54%

See 1 more Smart Citation

Description of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum

et al. 2017

View full text Add to dashboard Cite

Feline injection-site sarcomas were initially described by Hendrick and Goldschmidt (1991). The link between vaccination site and sarcoma occurrence suggested the term of vaccine-associated sarcomas. Our paper describes an unusual feline injection-site fi brosarcoma with cerebellar metastasis. A 7-year-old female domestic short-hair cat was submitted to the Pathology Department (Faculty of Veterinary Medicine ClujNapoca, Romania) for necropsy. A subcutaneous tumor (relapse) in the interscapular region and multiple metastatic masses in the lungs, kidneys, subcutaneous tissue (scapular and thigh regions) and cerebellum were observed. Cytological, histological and immunohistochemical (for vimentin, desmin, multi-cytokeratin, α-smooth muscle actin, S100 and CD45) analyses from all tumors were performed. Cytological examination identifi ed highly pleomorphic spindle-shaped cells admixed with neoplastic multinucleated giant cells. Histologically, all neoplastic masses were composed of numerous spindle cells arranged into interlacing bundles. Extensive intratumoral areas of necrosis along with a neutrophilic infi ltrate were also detected. A fi brillary material was present among neoplastic cells (green stained by Masson's trichrome method), suggesting a collagenous structure. In all tumors assessed, immunohistochemistry showed an intense reaction only for vimentin in numerous neoplastic cells. Based on the history, gross, cytological, histological and immunohistochemical data, the fi nal diagnosis was recurrent feline injection-site fi brosarcoma, with multiple metastases (including in the cerebellum). Overall, an uncommon case of feline injection-site fi brosarcoma has been reported. This is the fi rst consistent record of an injection site sarcoma in a cat with cerebellar metastasis.

show abstract

Section: Discussioncontrasting

confidence: 54%

“…However, other sarcoma types were reported, such as: osteosarcoma, condrosarcoma, myxosarcoma, rhabdomyosarcoma, malignant fi brous histiocytoma, myofi broblastic sarcoma and undifferentiated sarcoma [3,8,15,22,24,[26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Description of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum

et al. 2017

View full text Add to dashboard Cite

show abstract

“…As it was shown in our research, histopathological analysis of randomly selected 26 archival cases revealed that free margins were present only in 2 sarcomas. Free margins were shown to be related to more favorable prognosis in cases of FISS (Giudice et al 2010). The results obtained suggest that widespread and precise owners; education by veterinarians is necessary, because delaying diagnosis and surgery makes complete resection hard to perform or even impossible due to very fast growth of FISS.…”

Section: Discussionmentioning

confidence: 83%

Epidemiological and morphological analysis of feline injection site sarcomas

Kliczkowska¹,

Jankowska²,

Jagielski³

et al. 2015

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

Feline injection site sarcomas (FISS) are malignant neoplasms of mesenchymal origin which arise in sites of injections in cats. The prevalence is estimated between 1 in 1000 and 1 in 10 000 vaccinations in the United Kingdom. The aim of this study was to estimate the incidence of FISS in Poland and to analyse clinical aspects and histological and cytological features of injection site sarcomas. In our study the prevalence of FISS was 0.16% (16 FISS on 10.000 of cats) in feline patients in one of a veterinary surgery which conducts the general practice and 85 on 10.000 cats in a practice focused on veterinary oncology. The most typical microscopic features of FISS found in the present analysis were: the presence of perilesional scarring and inflammation, aggregates of lymphocytes at the tumour periphery, moderate but usually marked cellular pleomorphism and intralesional necrosis. The most typical cytologic features of FISS found in present study were: the presence of neutrophils, marked cellular pleomorphism, the presence of lymphocytes and macrophages, the presence of extremely large nuclei in the neoplastic cells, and high sample cellularity.

show abstract

“…One of the widespread prognostic factors for FISS is complete excision with clean margins of neoplasm at the first surgical procedure, which seems to contribute towards an increase in DFI (Davidson et al, 1997;Hershey et al, 2000) and OS (Davidson et al, 1997), although two recent studies reported an absence of correlation between the status of surgical margins and prognosis (Cohen et al, 2001, Martano et al, 2005. The obtainment of clean surgical margins is considered important for predicting local recurrence of FISS (Kobayachi et al, 2002;Giudice et al, 2010). But there are reports of up to 50% recurrence rates in neoplasms excised with clear surgical margins (Romanelli et al, 2008;Phelps et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…But there are reports of up to 50% recurrence rates in neoplasms excised with clear surgical margins (Romanelli et al, 2008;Phelps et al, 2011). This high recurrence rate can be explained by an asymmetrical dissemination of neoplastic cells, hindering accurate margin assessment (Giudice et al, 2010;Ehrhart & Powers, 2013). Another theory is that the inflammation caused by the surgical treatment can cause a new oncogenic process in genetically predisposed patients, causing recurrence (Ladlow, 2013).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of adjuvant chemotherapy in feline injection site-associated sarcoma

Pereira

Campos

Horta

et al. 2017

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

Feline Injection Site-Associated Sarcoma (FISS) is a neoplasm that implies in reduction of quality of life and overall survival in feline patients. A retrospective study of 13 cases of FISS was conducted to evaluate the efficacy of surgical treatment associated to chemotherapy with doxorubicin or carboplatin. Local recurrence occurred in all patients. Patients treated with surgery and chemotherapy presented a longer overall survival and disease-free interval when compared to those that solely received surgical treatment, although no statistical significance was observed (p= 0.3360 and 0.7506, respectively). Surgery remains as the main option for FISS treatment. Further prospective studies with larger samples are warranted to investigate the benefit of chemotherapy for this neoplasm.Keywords: FISS, Doxorubicin, Carboplatin, surgery RESUMO O Sarcoma de Aplicação Felino (SAF) é uma neoplasia associada a redução na qualidade de vida e sobrevida global. O objetivo deste estudo foi avaliar a eficácia da quimioterapia associada à cirurgia no manejo do SAF. Estudo retrospectivo de 13 pacientes com SAF submetidos à cirurgia isolada ou

show abstract

Feline injection-site sarcoma: Recurrence, tumour grading and surgical margin status evaluated using the three-dimensional histological technique

Cited by 63 publications

References 23 publications

Description of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum

Description of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum

Epidemiological and morphological analysis of feline injection site sarcomas

Evaluation of adjuvant chemotherapy in feline injection site-associated sarcoma

Contact Info

Product

Resources

About