Features of the Development of Metabolic Violations in Children Population, Residing in Conditions of Chronic Peroral Exposure of Chlororganic Compounds

Abstract

Sanitary and hygienic analysis of drinking water quality was carried out and health risk assessment of the population living in the industrial areas of the Perm region and consuming drinking water with high content of organochlorine compounds (Tetrachloromethane to 3.7 MPC, chloroform to 2.8 MPC). In the conditions of oral exposure to COC in the population formed unacceptable non-carcinogenic risk of endocrine system pathology (HI = 1.72, due to the influence of chloroform (85.7 %). In exposed children with high concentrations of chloroform and Tetrachloromethane in the blood, endocrine system pathology was diagnosed 2,0–2,4 times more often, the relative risk of obesity (E66.0) and redundant power supply (E67.8) 2.4 times higher than the indicators of the comparison group. A reliable causeand– effect relationship between the development of metabolic disorders (obesity and overweight) and the consumption of drinking water with high content of chos (OR = 2,4; DI = 1,05–6,8) was established; the proportion of the explained variance was R2 = 0,3–0,34; 85,4 ≤ F ≥ 112,8; p < 0,001. As features of the development of metabolic disorders in the population for a long time consuming drinking water with high content of chos (Tetrachloromethane, chloroform) revealed a sharp disharmony of physical development, early formation of excess body weight and obesity, an increase of 1,4–1,6 times the level Of C-peptide and leptin in the blood, insulin resistance index HOMA-IR, (p < 0,05).

Drinking water quality: health risk factors and efficiency of control and surveillance activities by Rospotrebnadzor

“…), в 2018 г. 12,43 % населения страны (в том числе 5,32 % -городского и 32,72 % -сельского) не было обеспечено безопасной питьевой водой из систем централизованного водоснабжения 4 . В 2018 г. в Российской Федерации с загрязнением питьевой воды химическими веществами (хлор и хлорорганические соединения, аммиак, железо, марганец, мышьяк, никель, медь, бор, магний и др.)…”

“…В 2018 г. в Российской Федерации с загрязнением питьевой воды химическими веществами (хлор и хлорорганические соединения, аммиак, железо, марганец, мышьяк, никель, медь, бор, магний и др.) и микробиологическими агентами было ассоциировано около 16,1 тысячи случаев смерти (по причине болезней системы кровообращения, органов пищеварения, злокачественных новообразований, некоторых инфекционных и паразитарных заболеваний) и 1764,49 тысячи случаев заболеваний органов пи-щеварения, мочеполовой системы, костно-мышечной системы и соединительной ткани, системы кровообращения, кожи и подкожной клетчатки, эндокринной системы и других болезней [1][2][3][4][5].…”

Drinking water quality: health risk factors and efficiency of control and surveillance activities by Rospotrebnadzor

“…Despite a certain growth achieved in providing RF population with water corresponding to all safety requirements (by 1.97% in 2018 against 2014), in 2018 12.43% people in the country (5.32% among urban population and 32.72%, among rural one) were not provided with safe drinking water from centralized water supply systems 4 .…”

“…In 2018 in the RF approximately 16.1 thousand death cases (due to circulatory system diseases, digestive organs diseases, malignant neoplasms, certain infectious and parasitic diseases) and 1,764.49 thousand diseases in the digestive organs, urogenital system, musculoskeletal system and conjunctive tissue, circulatory system, skin and subcutaneous tissue, endocrine system and some other diseases were caused by drinking water that was contaminated with various chemicals (chlorine and chlorinated organic compounds, ammonia, iron, manganese, arsenic, nickel, copper, boron, magnesium, etc.) and microbe agents [1][2][3][4][5].…”