Features of neurological manifestations of the COVID-19 in children and adults

Холин, А. А.; Заваденко, Н. Н.; Nesterovskiy, Yu E; Kholina, E. A.; Zavadenko, A. N.; Khondkaryan, G Sh

doi:10.17116/jnevro2020120091114

Cited by 17 publications

(8 citation statements)

References 43 publications

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“… 54 Encephalopathy is recognized as the most common CNS complication of COVID-19, caused by hypoxia or systemic diseases. 86 Statistically, ~50% of hospitalized patients with COVID-19 have encephalopathy, 87 with common signs including dizziness, cognitive dysfunction, ataxia, mental disorder, or even impaired consciousness. Old people with hepatic, cardiovascular, and renal comorbidities, as well as immunosuppressed persons, are more likely to develop encephalopathy following COVID-19 infection.…”

Section: Central Nervous System Diseases And/or Symptomsmentioning

confidence: 99%

Neurological complications and infection mechanism of SARS-CoV-2

Wan

Hong

et al. 2021

Sig Transduct Target Ther

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Currently, SARS-CoV-2 has caused a global pandemic and threatened many lives. Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS-CoV-2 can also invade the central nervous system (CNS) and peripheral nervous system (PNS) causing multiple neurological diseases, such as encephalitis, encephalopathy, Guillain-Barré syndrome, meningitis, and skeletal muscular symptoms. Despite the increasing incidences of clinical neurological complications of SARS-CoV-2, the precise neuroinvasion mechanisms of SARS-CoV-2 have not been fully established. In this review, we primarily describe the clinical neurological complications associated with SARS-CoV-2 and discuss the potential mechanisms through which SARS-CoV-2 invades the brain based on the current evidence. Finally, we summarize the experimental models were used to study SARS-CoV-2 neuroinvasion. These data form the basis for studies on the significance of SARS-CoV-2 infection in the brain.

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Section: Central Nervous System Diseases And/or Symptomsmentioning

confidence: 99%

Neurological complications and infection mechanism of SARS-CoV-2

Wan

Hong

et al. 2021

Sig Transduct Target Ther

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“…Symptoms lasting more than 28 days were dominated by fatigue (84%), headache, and anosmia (80%), especially in females and in the older age group, with most patients recovering by day 56 [28]. Another study included 510 children with symptoms persisting for four weeks, of whom only 4.3% were hospital-Researchers currently accept that the neurological manifestations of COVID-19 are diverse and can be divided into non-specifi c (for example, headache, myalgia, fatigue, drowsiness) and specifi c (encephalopathy, stroke, seizures, meningeal syndrome); it has been proposed that outcomes should be divided into acute, continuing and long-term [34][35][36][37].…”

mentioning

confidence: 99%

Neurological Aspects of the Sequelae of COVID-19 in Children

Nemkova

2022

Neurosci Behav Physi

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It has now been established that neurological and neuropsychiatric disorders persist for prolonged periods in a signifi cant proportion of adult patients who have had COVID-19, though there is much less information about the manifestations of post-COVID syndrome (PCS) in children and adolescents. This review presents data on the features of the course of PCS in young patients, and considers the options for treating these patients. The results of studies on the use of Cortexin for correcting cognitive and emotional disorders are analyzed.

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“…This cytokine storm hypothesis is reflected in our study by the higher CRP, creatinine, and Serum Glutamic Oxaloacetic Transaminase (SGOT) levels in the severe group, suggesting damage to multiple organs, including kidneys and liver. On the other hand, encephalopathy due to hypoxia or systemic inflammation seems to be the most common CNS complication of COVID-19 [27]. Risk factors for encephalopathy include older or immunosuppressed patients with cardiovascular, hepatic and renal comorbidities [6].…”

Section: Discussionmentioning

confidence: 99%

Neurological Manifestations of Coronavirus Disease 2019 in Hospitalized Patients: A Lebanese Cohort Study

Hajj¹,

Hassoun²,

Harb³

et al. 2023

Cureus

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Background: Concerns regarding potential neurologic complications of COVID-19 are being increasingly reported worldwide. Our objective was to investigate the neurologic complications of COVID-19 among a cohort of Lebanese patients with SARS-CoV-2 infection admitted to Rafik Hariri University Hospital (RHUH), the leading COVID-19 testing and treatment center in Lebanon.Methods: This is a retrospective, single-center, observational study conducted from March to July 2020 at RHUH, Lebanon.Results: Of 169 hospitalized patients with confirmed SARS-CoV-2 infection (mean {SD} age was 45.75 {19} years and 62.7% were men), 91 patients (53.8%) had severe infection and 78 patients (46.2%) had non-severe infection according to the American Thoracic Society guidelines for community-acquired pneumonia. Overall, 112 patients (66.3%) developed neurologic symptoms: CNS (46.1%), PNS (43.7%), and skeletal muscle injury (2.4%). Compared with patients with non-severe infection, patients with severe infection were significantly older, were male and more likely to have underlying disorders, especially diabetes and cardiac or cerebrovascular disease. Moreover, those patients experienced more typical COVID-19 symptoms at onset of illness such as fever, cough and fatigue. However, there was no significant difference in the frequency of all nervous system manifestations between the severe and the non-severe infection groups (57 {62.6%} vs 55 {70.5%}; p =0.316), except for impaired consciousness, where seven patients had impaired consciousness in the severe group compared to none in the non-severe group (p=0.012). Conclusion:A wide variety of neurologic symptoms were detected in our Lebanese cohort of hospitalized COVID-19 patients. A comprehensive knowledge of the neurologic manifestations will help healthcare providers to be more attentive to these complications.

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Features of neurological manifestations of the COVID-19 in children and adults

Cited by 17 publications

References 43 publications

Neurological complications and infection mechanism of SARS-CoV-2

Neurological complications and infection mechanism of SARS-CoV-2

Neurological Aspects of the Sequelae of COVID-19 in Children

Neurological Manifestations of Coronavirus Disease 2019 in Hospitalized Patients: A Lebanese Cohort Study

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