Features of Clinical Symptoms and Signs, Hematological and Biochemical Parameters in Children With Joint Hypermobility in a Late Period Upon the Chornobyl NPP Accident

Bebeshko, V.; Bruslova, K M; Lyashenko, L O; Tsvetkova, Nelly M.; Trychlib, I V; Chernysh, T O; Boyarskiy, V.; Gonchar, L O; Kavardakova, N.

doi:10.33145/2304-8336-2019-24-322-334

Cited by 4 publications

(3 citation statements)

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“…Oxyproline (OXYP), as a major collagen amino acid, is an important component of the connective tissue and one of the products of its metabolism. Its concentration in the blood may be a marker of connective tissue disorders [13].…”

Section: Introductionmentioning

confidence: 99%

Features of heritable disorders of connective tissue in children with acute rheumatic fever and rheumatic heart disease

Boyarchuk

2020

Reumatologia

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Objectives: Heritable disorders of connective tissue (HDCT) are associated with morphological and functional disorders of different organs and systems. The aim of our study was to determine the clinical signs of heritable disorders of connective tissue and oxyproline levels in children with acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Material and methods: A total of 155 patients aged 4 to 17 years participated in the study: 23 with ARF, 78 with RHD, and 54 healthy patients with a history of ARF. All patients underwent a standardized examination protocol, which consisted of a detailed medical history recorded by the physician, general and special laboratory tests, electrocardiogram, echocardiography, and Doppler echocardiography. Special attention was paid to the clinical signs of HDCT. The intensity of the metabolic processes in the connective tissue was evaluated by serum oxyproline levels. Results: The signs of HDCT were revealed in 121 (78.1%) of the patients with ARF and RHD. Among cardiovascular manifestations, we observed mitral valve prolapse most often-in 91 (58.7%) patients. Musculoskeletal anomalies were observed in 94 (60.7%) patients. Both groups of patients with ARF and RHD had elevated mean serum oxyproline levels. Conclusions: Children with acute rheumatic fever and rheumatic heart disease presented with a number of signs characteristic of heritable connective tissue disorders. The cardiovascular and musculoskeletal system changes are the most frequent among all features of HDCT. Elevated levels of serum oxyproline in patients with ARF and RHD confirm connective tissue disorders. Children with manifestations of HDCT are at the risk of ARF and RHD development.

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Section: Introductionmentioning

confidence: 99%

Features of heritable disorders of connective tissue in children with acute rheumatic fever and rheumatic heart disease

Boyarchuk

2020

Reumatologia

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“…Çà îñòàíí³ ðîêè ïðîáëåì³ çàõâîðþâàíü ñêðîíåâî-íèaeíüîùåëåïíîãî ñóãëîáà (ÑÍÙÑ) ïðèñâÿ÷åíî áàãàòî åï³äåì³îëîã³÷íèõ ðîá³ò, ó ÿêèõ çâåðíåíî óâàãó íà øèðîêó ïîøèðåí³ñòü ïàòî-ëîã³¿ ÑÍÙÑ ó îñ³á ð³çíî¿ ñòàò³ òà â³êó, ùî ðîçâèâàºòüñÿ íà ôîí³ ãåíåòè÷íî-äåòåðì³íîâàíî¿ ñëàáêîñò³ ñïîëó÷íî¿ òêàíèíè (ÑÒ), ùî º âîäíî÷àñ ï³ä´ðóíòÿì äëÿ âèíèêíåííÿ ð³çíîìàí³òíèõ ñóïóòí³õ çàõâîðþâàíü ïîë³ãåííî-ìóëüòèôàêòîðíî¿ ïðèðîäè, â òîìó ÷èñë³ îðãàí³â ñå÷îâèä³ëüíî¿ ñèñòåìè (ÑÂÑ) [1][2][3].Àêòóàëüí³ñòü äîñë³äaeåííÿ âíóòð³øí³õ îðãàí³â ³ âèçíà÷åííÿ ñòàíó ÑÒ ó õâîðèõ ³ç ïàòîëîã³ºþ ÑÍÙÑ îáóìîâëåíà çðîñòàííÿì ÷àñòîòè ïàòîëîã³÷íèõ ñòàí³â, ïîâ'ÿçàíèõ ³ç äèñïëàç³ºþ ÑÒ, ÿêà ðîçâèâàºòüñÿ â ðåçóëüòàò³ âïëèâó íåñïðèÿòëèâèõ ôàêòîð³â çîâ-í³øíüîãî ñåðåäîâèùà íà îðãàí³çì ëþäèíè ï³ä ÷àñ âíóòð³øíüîóòðîáíîãî ðîçâèòêó òà ï³ñëÿ íàðîäaeåííÿ, ïîðóøåííÿ õàð÷óâàííÿ, çíèaeåííÿ ð³âíÿ aeèòòÿ, ñòðåñ òîùî. ßê íàñë³äîê -äî êë³í³êè äåäàë³ ÷àñò³øå çâåðòàþòüñÿ ïàö³ºíòè ìîëîäîãî â³êó ³ç ïðîÿâàìè äèñïëàñòè÷íèõ ñòàí³â ÑÒ, íà ôîí³ ÿêèõ ðîçâèâàþòüñÿ àðòðîïàò³¿ ÑÍÙÑ [2,4,5].Äèñïëàñòè÷í³ çì³íè ÑÒ äîñèòü ÷àñòî ïîºäíóþòüñÿ ç ïàòîëîã³ºþ íèðîê ³ ñå÷îâèâ³äíèõ øëÿõ³â [6,7]. Ìàéaeå êîaeåí òðåò³é ïàö³ºíò ìàº ñèìïòîìè, õàðàê-òåðí³ äëÿ çàõâîðþâàíü ÑÂÑ: ÷àñò³ ñå÷îâèïóñêàííÿ, â³ä÷óòòÿ íåïîâíîãî âèïîðîaeíåííÿ ñå÷îâîãî ì³õóðà, í³êòóð³ÿ, åíóðåç, ñèìïòîìè äèñìåòàáîë³÷íî¿ íåôðî-ïàò³¿, ïîë³ê³ñòîç, äèâåðòèêóëüîç ñå÷îâîãî ì³õóðà, íåôðîïòîç, àòîí³ÿ ÷àøêîâî-ìèñêîâî¿ ñèñòåìè, àòèïîâå ðîçì³ùåííÿ íèðêè, ïîäâîºííÿ íèðêè òà/÷è ñå-÷îâèä³ëüíèõ øëÿõ³â [7].…”

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“…Äèñïëàñòè÷í³ çì³íè ÑÒ äîñèòü ÷àñòî ïîºäíóþòüñÿ ç ïàòîëîã³ºþ íèðîê ³ ñå÷îâèâ³äíèõ øëÿõ³â [6,7]. Ìàéaeå êîaeåí òðåò³é ïàö³ºíò ìàº ñèìïòîìè, õàðàê-òåðí³ äëÿ çàõâîðþâàíü ÑÂÑ: ÷àñò³ ñå÷îâèïóñêàííÿ, â³ä÷óòòÿ íåïîâíîãî âèïîðîaeíåííÿ ñå÷îâîãî ì³õóðà, í³êòóð³ÿ, åíóðåç, ñèìïòîìè äèñìåòàáîë³÷íî¿ íåôðî-ïàò³¿, ïîë³ê³ñòîç, äèâåðòèêóëüîç ñå÷îâîãî ì³õóðà, íåôðîïòîç, àòîí³ÿ ÷àøêîâî-ìèñêîâî¿ ñèñòåìè, àòèïîâå ðîçì³ùåííÿ íèðêè, ïîäâîºííÿ íèðêè òà/÷è ñå-÷îâèä³ëüíèõ øëÿõ³â [7].…”

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Manifestations of Urinary System Pathology at Young Age Patients With Temporоmandibular Joint Diseases

Kryzhanivska

2019

Med. Sci. of Ukr.

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Relevance. In recent years, many have been devoted to the problem of the temporomandibular joint (TMJ) diseases, in which the attention is paid to the widespread pathology of TMJ at young people, which develops against the background of genetically-determined weakness of connective tissue (CT), which is also present occurrence of various concomitant diseases of polygenic-multifactorial nature, including the organs of the urinary system (US). Objective. To investigate the manifestations of US pathology in young patients with TMJ diseases. Materials and methods. The study involved 32 patients (m-4, w-28) with diseases of the TMJ, whose average age was 31.6 ± 7.7 years, who were treated at the Dental Medical Center of the Bogomolets NMU. Manifestations of US pathology in patients of this group have been investigated. Examination of patients was performed according to the classical method of examination of patients with diseases of the TMJ. The orthopantomography with examination of the mandibular heads, open mouth X-ray by Parma, computed tomography or MRI scan, iridobiomicroscopy were obligatory. The presence of pathology of US was founding out from the anamnesis vitae, the patient was referred for consultation to a nephrologist. Ultrasound of the kidneys, urinary tract, urine tests were performed for all examined patients. The obtained laboratory data were referenced in the International System of Units and processed by variational statistics using MedStat and EZR v.1.35 (Saitama Medical Center, Jichi Medical University, Saitama, Japan, 2017), which is a graphical interface to RFSC (The R Foundation for Statistical Computing, Vienna, Austria). Results. The following manifestations of TMJ pathology were found in young patients with US diseases: chronic cystitis – 37.5% of cases, oxalate or urinary crystalluria – 37.5 %, nephroptosis – 9.4 %, urolithiasis – 6.3 %, chronic pyelonephritis – 6.3 %, double kidney – 3.1 %. Structural local or chromatic changes of the iris stroma in the projection region of the kidney (75 %) and bladder (43.6 %) in young patients with TMJ diseases showed a congenital weakness of the CT of these organs and a tendency to develop pathology of the US. Changes in urine tests were mainly in the form of oxalate crystalluria (34.4 %), increase specific gravity (15.6 %), proteinuria (9.4 %), which further confirmed the present pathology of the urinary system. Conclusions. The manifestations of developmental abnormalities and other kidney and bladder diseases found in young patients with TMJ disease suggest that there is a correlation between flow of pathological processes in the TMJ and US, which may be based on changes in the CT system. When planning the treatment of young patients with TMJ diseases and pathology of US, medicines that do not affect the urinary system and do not provoke exacerbation of the disease should be prescribed. In the presence of pathology of the kidneys and/or urinary tract, the ultrasound of this system should be prescribed in consultation with a nephrologist.

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Iris Changes at Patients With Temporоmandibular Joint Diseases and Urinary System Pathology

Kryzhanivska

2020

Med. Sci. of Ukr.

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Relevance. In recent years, many have been devoted to the problem of the temporomandibular joint (TMJ) diseases, in which the attention is paid to the widespread pathology of TMJ in young people, which develops against the background of the genetically-determined weakness of connective tissue (CTs), which is also the present occurrence of various concomitant diseases of polygenic-multifactorial nature, including the organs of the urinary system (US). The study of the state of the iris is used as a screening technique that allows you to quickly, simply, harmlessly, informatively, painlessly, non-invasively diagnose the genetically determined structural and functional state and quality of the CTs. Objective. To investigate the iris changes in patients with TMJ and US diseases, to reveal the dependence of the occurrence of degenerative-dystrophic and destructive-inflammatory changes in the joints and US on the structural and functional state of the CTs, to supplement the known traditional methods of diagnosing genetically determined CTs weakness. Materials and methods. The study involved 54 patients (men – 14, women – 40), whose average age was 37.3±7.6 years, who were treated at the Dental Medical Center of the Bogomolets NMU. Control group – 22 patients (men – 10, women – 12) without general somatic pathology, with a physiological bite, without signs of TMJ diseases, whose average age was 25.7±6.8 years. Main group – 22 patients (men – 4, women – 28) with TMJ diseases and US pathology, whose average age was 31.6±7.7 years. Iridobiomicroscopy was performed in patients of both groups. Iridogenetic constitutional signs were determined: the color of eyes, constitutional type after E.S. Velkhover, type with the connective tissue weakness after I. Deck, the density of iris stoma. The obtained laboratory data were referenced in the International System of Units and processed by variational statistics using MedStat and EZR v.1.35 (Saitama Medical Center, Jichi Medical University, Saitama, Japan, 2017), which is a graphical interface to RFSC (The R Foundation for Statistical Computing, Vienna, Austria). Results. Among the examined patients with TMJ diseases and MVS pathology, 75% showed predominantly light eye color and V degree (46.9%) of iris stroma density, in the control group: dark iris color (54.5%) and II degree (68.2%) of iris density. Iridogenetic constitutional signs of the CT weakness in the patients with TMJ diseases have been determined: the light color of eyes, radial-lacunar constitutional type after E.S. Velkhover (75%), lymphatic constitutional type with the connective tissue weakness after I. Deck (57,9%). Structural local or chromatic changes of the iris stroma in the projection region of the kidney (75%) and bladder (43.6%) in young patients with TMJ diseases showed a congenital weakness of the CTs of these organs and a tendency to develop pathology of the US. Conclusions. Patients with degenerative-dystrophic and destructive-inflammatory diseases of the TMJ and concomitant US pathology are characterized by iridogenetic constitutional signs of the CTs weakness in the patients with TMJ diseases have been determined: the light color of eyes, radial-lacunar constitutional type after E.S. Velkhover, low degree of iris stroma density, lymphatic constitutional type with the connective tissue weakness after I. Deck. Structural local or chromatic changes of the iris stroma in the projection region of the kidney and bladder in young patients with TMJ diseases showed a congenital weakness of the CTs of these organs and a tendency to develop pathology of the US. It can be assumed that the development of TMJ diseases in young patients is based on dysplastic changes in the CTs system, which is additionally manifested in the examined patients by pathological changes in the US. Iridobiomicroscopy, as a screening technique for determining the structural and functional state of CTs, makes it possible to increase the accuracy of diagnostics when examining patients with TMJ diseases who have concomitant pathology of internal organs, including US.

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Features of Clinical Symptoms and Signs, Hematological and Biochemical Parameters in Children With Joint Hypermobility in a Late Period Upon the Chornobyl NPP Accident

Cited by 4 publications

References 7 publications

Features of heritable disorders of connective tissue in children with acute rheumatic fever and rheumatic heart disease

Features of heritable disorders of connective tissue in children with acute rheumatic fever and rheumatic heart disease

Manifestations of Urinary System Pathology at Young Age Patients With Temporоmandibular Joint Diseases

Iris Changes at Patients With Temporоmandibular Joint Diseases and Urinary System Pathology

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