Feasibility of concurrent adjuvant chemotherapy and radiotherapy after breast‐conserving surgery in early breast cancer

Han, Sehwan; Kim, Juree; Sohn, Seungchang; Kwak, Geum-Hee; Kim, Jiyoung; Park, Kyeongmee

doi:10.1002/jso.20715

Cited by 6 publications

(2 citation statements)

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“…We started chemotherapy (mostly not adriamycin-based) during or right after APBI and the chemotherapy use did not affect late toxicity. Previously, we reported the non-inferior safety of concurrent chemoradiotherapy compared to sequential chemoradiotherapy using WBI for early-stage breast cancer [2]. However, the use of larger fraction dose in APBI compared to WBI may necessitate careful administration of chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…However, the 5-6 weeks of conventional WBI are problematic for elderly patients, working women, and those who live a great distance from a radiotherapy facility [1]. In addition, controversies and logistical problems exist that are associated with integrating this prolonged course of WBI and systemic chemotherapy [2]. These make a barrier to the acceptance of breast conservation by patients or their physicians, and some patients do not receive WBI after BCS [3].…”

Section: Introductionmentioning

confidence: 99%

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Accelerated partial breast irradiation using multicatheter brachytherapy for select early-stage breast cancer: local control and toxicity

et al. 2010

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BackgroundTo investigate the efficacy and safety of accelerated partial breast irradiation (APBI) via high-dose-rate (HDR) multicatheter interstitial brachytherapy for early-stage breast cancer.MethodsBetween 2002 and 2006, 48 prospectively selected patients with early-stage breast cancer received APBI using multicatheter brachytherapy following breast-conserving surgery. Their median age was 52 years (range 36-78). A median of 34 Gy (range 30-34) in 10 fractions given twice daily within 5 days was delivered to the tumor bed plus a 1-2 cm margin. Most (92%) patients received adjuvant systemic treatments. The median follow-up was 53 months (range 36-95). Actuarial local control rate was estimated from surgery using Kaplan-Meier method.ResultsLocal recurrence occurred in two patients. Both were true recurrence/marginal miss and developed in patients with close (< 0.2 cm) surgical margin after 33 and 40 months. The 5-year actuarial local recurrence rate was 4.6%. No regional or distant relapse and death has occurred to date. Late Grade 1 or 2 late skin and subcutaneous toxicity was seen in 11 (22.9%) and 26 (54.2%) patients, respectively. The volumes receiving 100% and 150% of the prescribed dose were significantly higher in the patients with late subcutaneous toxicity (p = 0.018 and 0.034, respectively). Cosmesis was excellent to good in 89.6%.ConclusionsAPBI using HDR multicatheter brachytherapy yielded local control, toxicity, and cosmesis comparable to those of conventional whole breast irradiation for select early-stage breast cancer. Patients with close resection margins may be ineligible for APBI.

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Section: Discussionmentioning

confidence: 99%