Concomitant adjuvant chemo-radiation therapy with anthracyclinebased regimens in breast cancer: a single centre experience

Livi, Lorenzo; Meattini, Icro; Scotti, Vieri; Saieva, Calogero; Simontacchi, Gabriele; Marrazzo, L.; Franzese, Ciro; Cassani, S.; Paiar, Fabiola; Cataldo, Vanessa Di; Nori, Jacopo; Sanchez, Luis; Bianchi, Simonetta; Cataliotti, Luigi; Biti, Gianpaolo

doi:10.1007/s11547-011-0652-2

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…Historically, in particular in breast cancer series, the association of anthracyclines-based chemotherapy with irradiation was correlated with higher acute and late skin toxicity and cardiac complications; for these reasons, concurrent radiotherapy and anthracyclines-based chemotherapy are detrimental in this population. 13…”

Section: Discussionmentioning

confidence: 99%

Safety of concurrent adjuvant radiotherapy and chemotherapy for locally advanced soft tissue sarcoma

Greto

Loi

Saieva

et al. 2018

Tumori

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Section: Discussionmentioning

confidence: 99%

Safety of concurrent adjuvant radiotherapy and chemotherapy for locally advanced soft tissue sarcoma

Greto

Loi

Saieva

et al. 2018

Tumori

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“…Acute and delayed cutaneous toxicity of irradiation has been proven that are related to systemic adjuvant chemotherapy regimens (i.e., the use of Taxane and Anthracycline) (56)(57)(58)(59). Thus, the concurrent use of RT and anthracycline or Taxan is generally not recommended.…”

Section: Patient Factors and Other Treatment-related Itemsmentioning

confidence: 99%

Toxicity of Adjuvant Radiotherapy in Patients with Breast Cancer: A Review Study Toxicity of Breast Adjuvant Radiotherap

Javadinia

Dehghani

Ferns

et al. 2019

Rep Radiother Oncol

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Conservative treatment in early-stage breast cancer is considered a standard approach. Breast preserving surgery with adjuvant radiotherapy is as effective as mastectomy in the early stages of breast cancer to control local disease and distant metastasis and maintain the overall survival rate. Minimally invasive surgery for the treatment of axillary spread and new techniques of breast preservation surgery will probably lead to a reduction in mastectomy-related complications. However, the complications of adjuvant radiotherapy remain a challenge. Cutaneous, cardiac, and pulmonary toxicity are the main complications of adjuvant breast irradiation. The multidisciplinary features (systemic treatment, endocrine therapy, and surgery), patient profile (history of underlying diseases, age, and habits), and irradiation-associated parameters are the factors affecting safe adjuvant radiotherapy. Advances in irradiation techniques and facilities related to the preservation of organs at risk (such as IGRT, tracing and tracking systems, and respiratory gating) are modern tools for reducing the risk of toxicity. Reported data from clinical trials or retrospective surveys greatly help physicians in consulting the patients on the efficacy and potential side effects of treatment and leads to the improvement of the decision making process.

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“…Set up variation with two tangent fields has been demonstrated to expose the myocardium to a higher dose of radiation leading to myocardial hypoperfusion (6). Radiation-induced myocardial damage is often clinically silent even when there was significant reduction of the left ventricular ejection fraction (7). The damage to the heart may be worse in patients with pre-existing cardiovascular conditions such as high blood pressure or left ventricle dysfunction (8).…”

Section: Cardiac Toxicity Following Left Breast Cancer Irradiationmentioning

confidence: 99%

Image-Guided Radiotherapy for Cardiac Sparing in Patients with Left-Sided Breast Cancer

et al. 2014

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Patients with left-sided breast cancer are at risk of cardiac toxicity because of cardiac irradiation during radiotherapy with the conventional 3-dimensional conformal radiotherapy technique. In addition, many patients may receive chemotherapy prior to radiation, which may damage the myocardium and may increase the potential for late cardiac complications. New radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) may decrease the risk of cardiac toxicity because of the steep dose gradient limiting the volume of the heart irradiated to a high dose. Image-guided radiotherapy (IGRT) is a new technique of IMRT delivery with daily imaging, which may further reduce excessive cardiac irradiation. Preliminary results of IGRT for cardiac sparing in patients with left-sided breast cancer are promising and need to be investigated in future prospective clinical studies.

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Concomitant adjuvant chemo-radiation therapy with anthracyclinebased regimens in breast cancer: a single centre experience

Abstract: In our experience, concomitant chemotherapy did not emerge as a significant factor in radiotherapy interruption. Moreover, no severe cardiac events were recorded.

Cited by 6 publications

References 35 publications

Safety of concurrent adjuvant radiotherapy and chemotherapy for locally advanced soft tissue sarcoma

Safety of concurrent adjuvant radiotherapy and chemotherapy for locally advanced soft tissue sarcoma

Toxicity of Adjuvant Radiotherapy in Patients with Breast Cancer: A Review Study Toxicity of Breast Adjuvant Radiotherap

Image-Guided Radiotherapy for Cardiac Sparing in Patients with Left-Sided Breast Cancer

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