Feasibility of chitosan-alginate (Chi-Alg) hydrogel used as scaffold for neural tissue engineering: a pilot study<i>in vitro</i>

Wang, Gan; Wang, Xiaoyan; Huang, Lixiang

doi:10.1080/13102818.2017.1332493

Cited by 53 publications

(51 citation statements)

References 37 publications

(39 reference statements)

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“…Similarly, alginic acid/alginate as a natural polysaccharide has a similar chemical structure to chitosan but contains carboxylic instead of amine groups. Due to the opposite charges, chitosan and alginate can easily form electrostatic complexes [95].…”

Section: Chitosan-polymer Mixture or Copolymermentioning

confidence: 99%

Chitosan Nanocomposite Coatings for Food, Paints, and Water Treatment Applications

et al. 2019

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Worldwide, millions of tons of crustaceans are produced every year and consumed as protein-rich seafood. However, the shells of the crustaceans and other non-edible parts constituting about half of the body mass are usually discarded as waste. These discarded crustacean shells are a prominent source of polysaccharide (chitin) and protein. Chitosan is a de-acetylated form of chitin obtained from the crustacean waste that has attracted attention for applications in food, biomedical, and paint industries due to its characteristic properties, like solubility in weak acids, film-forming ability, pH-sensitivity, biodegradability, and biocompatibility. We present an overview of the application of chitosan in composite coatings for applications in food, paint, and water treatment. In the context of food industries, the main focus is on fabrication and application of chitosan-based composite films and coatings for prolonging the post-harvest life of fruits and vegetables, whereas anti-corrosion and self-healing properties are the main properties considered for antifouling applications in paints in this review.

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Section: Chitosan-polymer Mixture or Copolymermentioning

confidence: 99%

Chitosan Nanocomposite Coatings for Food, Paints, and Water Treatment Applications

et al. 2019

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“…The biodegradation and gelation capability of the injectable gels influenced the drug release ability of the system. Chitosan-alginate hydrogel showed an improved alternative for neural tissue engineering [91]. The hydrogel was hydrophilic with a porous structure.…”

Section: In Situ Gelmentioning

confidence: 99%

Chitosan-Based Nanocarriers for Nose to Brain Delivery

Aderibigbe

Naki

2019

Applied Sciences

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In the treatment of brain diseases, most potent drugs that have been developed exhibit poor therapeutic outcomes resulting from the inability of a therapeutic amount of the drug to reach the brain. These drugs do not exhibit targeted drug delivery mechanisms, resulting in a high concentration of the drugs in vital organs leading to drug toxicity. Chitosan (CS) is a natural-based polymer. It has unique properties such as good biodegradability, biocompatibility, mucoadhesive properties, and it has been approved for biomedical applications. It has been used to develop nanocarriers for brain targeting via intranasal administration. Nanocarriers such as nanoparticles, in situ gels, nanoemulsions, and liposomes have been developed. In vitro and in vivo studies revealed that these nanocarriers exhibited enhanced drug uptake to the brain with reduced side effects resulting from the prolonged contact time of the nanocarriers with the nasal mucosa, the surface charge of the nanocarriers, the nano size of the nanocarriers, and their capability to stretch the tight junctions within the nasal mucosa. The aforementioned unique properties make chitosan a potential material for the development of nanocarriers for targeted drug delivery to the brain. This review will focus on chitosan-based carriers for brain targeting.

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“…Such is the case of the work led by Likewise, a chitosan/alginate composite hydrogel was suitable to support the growth of murine neural stem cells, as well as olfactory ensheathing cells, which are known to facilitate the recovery of spinal cord injury in vivo. Both types of cells proliferated upon stimulation with neural supplements such as B27 and bFGF after 7 days (G. Wang, Wang, & Huang, 2017).…”

Section: Naturally Derived Hydrogels For Treatment Of Neuropathymentioning

confidence: 99%

Advanced hydrogels for treatment of diabetes

Reyes-Martínez

Ruíz-Pacheco²,

Flores-Valdéz

et al. 2019

J Tissue Eng Regen Med

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Diabetes mellitus is a chronic disease characterized by high levels of glucose in the blood, which leads to metabolic disorders with severe consequences. Today, there is no cure for diabetes. The current management for diabetes and derived medical conditions, such as hyperglycemia, cardiovascular diseases, or diabetic foot ulcer, includes life style changes and hypoglycemia‐based therapy, which do not fully restore euglycemia or the functionality of damaged tissues in patients. This encourages scientists to work outside their boundaries to develop routes that can potentially tackle such metabolic disorders. In this regard, acellular and cellular approaches have represented an alternative for diabetics, although such treatments still face shortcomings related to limited effectiveness and immunogenicity. The advent of biomaterials has brought significant improvements for such approaches, and three‐dimensional extracellular matrix analogs, such as hydrogels, have played a key role in this regard. Advanced hydrogels are being developed to monitor high blood glucose levels and release insulin, as well as serve as a therapeutic technology. Herein, the state of the art in advanced hydrogels for improving treatment of diabetes, from laboratory technology to commercial products approved by drug safety regulatory authorities, will be concisely summarized and discussed.

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Feasibility of chitosan-alginate (Chi-Alg) hydrogel used as scaffold for neural tissue engineering: a pilot studyin vitro

Cited by 53 publications

References 37 publications

Chitosan Nanocomposite Coatings for Food, Paints, and Water Treatment Applications

Chitosan Nanocomposite Coatings for Food, Paints, and Water Treatment Applications

Chitosan-Based Nanocarriers for Nose to Brain Delivery

Advanced hydrogels for treatment of diabetes

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