Feasibility of a Natural Surfactant as a Stabilizer for Cosmetics with Liposome-Encapsulated Plant Stem Cells: Pre-Formulation and Formulation Through Stability Studies

Abstract

During the formulation of liposome-containing products different problems can occur and the selection of a suitable carrier remains the greatest challenge. To estimate feasibility of a novel alkyl polyglucoside surfactant (hydroxystearyl alcohol and hydroxystearyl glucoside) as an emulsifier for cosmetics with liposome-encapsulated plant stem cells, we performed a two-phase study. In the first, the pre-formulation phase, the emulsifier's critical micelle concentration (CMC) and liposome-encapsulated active-emulsifier interactions were determined. The second phase was carried out to develop and characterize a cosmetic emulsion suitable to serve as a carrier for liposomes. The investigated emulsifier, with the obtained CMC value of 0.0085 wt.%, could be classified as liposome-friendly and can be used to develop stable and aesthetically acceptable cosmetics or even prospective pharmaceutical liposome-containing emulsions.

Nanoemulsions Based on Sunflower and Rosehip Oils: The Impact of Natural and Synthetic Stabilizers on Skin Penetration and an Ex Vivo Wound Healing Model

“…It can be observed in the mathematical equations defined from the experimental design ( Table 4 ) that only the independent variables H20 and H100 influenced the viscosity of the formulations, increasing as a function of their concentration. Because it represents a mixture of phospholipids, H20 may favor the formation of phospholipids’ multilayers on the nanodroplets’ surface and alters the individual organization of the other emulsifiers at the oil–water interface, influencing the packaging and the rheology of the formulation [ 14 , 35 ].…”

Alp rose stem cells as cosmetic creams ingredient: Expected and established creams effects on the skin

“…Ispitivanje zadržavanja "obogaćenih" liposoma sa ekstraktom MĆAR ili neke druge KAS, u početnom stanju i bez narušavanja strukture i integriteta dvoslojnih membrana vezikula u kozmetičkim emulzionim sistemima, je veoma kompleksan zadatak i o tome ima malo podataka. Filipović i saradnici su kroz nekoliko radova opisali ispitivanja rađena sa kremovima sa mešanim emulgatorom APG tipahidroksistearil alkohol i hidroksistearil glukozidom (Simulgreen™ 18-2, proizvođača Seppic, Francuska) i liposomima sa ekstraktom matičnih ćelija alpske ruže, koja su se odnosila na procenu kompatibilnosti ovog nejonskog emulgatora i liposoma u formulisanim ulje u vodi (u/v) emulzionim sistemima, praćenjem njihovih interakcija, kao i efektima tih proizvoda na koži (13)(14)(15).…”

“…Izvršena kontinualna i oscilatorna reološka merenja u daljoj karakterizaciji ispitivanih kremova potvrdila su uticaj prisustva MĆAR-liposoma na reološko ponašanje nosača (placebo krema) u vidu blagog povećanja njegovog viskoziteta i ugušćivanja, kao i povećanja elastičnosti (veći elastični (G') od viskoznog modula (G'')), pri čemu je uticaj bio značajniji pri dodatku veće koncentracije MĆARliposoma (1% (m/m)). Prisustvo intaktnih liposoma u blizini lamelarne faze unutar emulzionih sistema potvrđeno je i diferencijalnom skenirajućom kalorimetrijom, kao i termogravimetrijskom analizom (13).…”