The emerging role of nanotechnology in skincare

Salvioni, Lucia; Morelli, Lucia; Machiste, E. Ochoa; Labra, Massimo; Fiandra, Luisa; Palugan, Luca; Prosperi, Davide; Colombo, Miriam

doi:10.1016/j.cis.2021.102437

Cited by 159 publications

(122 citation statements)

References 224 publications

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“…Plant mediated NPs with bioactive compounds capped over them have several benefits over chemical drugs, including efficacy at lower concentrations, target specificity, and the ability to cross the blood-brain barrier [12]. NPs also display anti-aging activity by inhibiting the formation of advanced glycation end products (AGEs) by competing with carbohydrates in binding with extra-cellular matrix proteins [13]. Therefore, NPs are emerging as cosmeceuticals and are becoming an important component of personal care products [14].…”

Section: Introductionmentioning

confidence: 99%

Light Tailoring: Impact of UV-C Irradiation on Biosynthesis, Physiognomies, and Clinical Activities of Morus macroura-Mediated Monometallic (Ag and ZnO) and Bimetallic (Ag–ZnO) Nanoparticles

Anjum

Khan

Qamar

et al. 2021

IJMS

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A nano-revolution based on the green synthesis of nanomaterials could affect all areas of human life, and nanotechnology represents a propitious platform for various biomedical applications. During the synthesis of nanoparticles, various factors can control their physiognomies and clinical activities. Light is one of the major physical factors that can play an important role in tuning/refining the properties of nanoparticles. In this study, biocompatible monometallic (AgNPs and ZnONPs) and bimetallic Ag–ZnONPs (0.1/0.1 and 0.1/0.5) were synthesized under UV-C light irradiation from the leaf extract of Morus macroura, which possesses enriched TPC (4.238 ± 0.26 mg GAE/g DW) and TFC (1.073 ± 0.18 mg QE/g DW), as well as strong FRSA (82.39%). These green synthesized NPs were evaluated for their anti-diabetic, anti-glycation, and biocompatibility activities. Furthermore, their anti-cancerous activity against HepG2 cell lines was assessed in terms of cell viability, production of reactive oxygen/nitrogen species, mitochondrial membrane potential, and apoptotic caspase-3/7 expression and activity. Synthesized NPs were characterized by techniques including ultraviolet-visible spectroscopy, SEM, EDX, FTIR, and XRD. UV-C mediated monometallic and bimetallic NPs showed well-defined characteristic shapes with a more disperse particle distribution, definite crystalline structures, and reduced sizes as compared to their respective controls. In the case of clinical activities, the highest anti-diabetic activity (67.77 ± 3.29% against α-amylase and 35.83 ± 2.40% against α-glucosidase) and anti-glycation activity (37.68 ± 3.34% against pentosidine-like AGEs and 67.87 ± 2.99% against vesperlysine-like AGEs) was shown by UV-C mediated AgNPs. The highest biocompatibility (IC50 = 14.23 ± 1.68 µg/mL against brine shrimp and 2.48 ± 0.32% hemolysis of human red blood cells) was shown by UV-C mediated ZnONPs. In the case of anti-cancerous activities, the lowest viability (23.45 ± 1.40%) with enhanced ROS/NOS production led to a significant disruption of mitochondrial membrane potential and greater caspase-3/7 gene expression and activity by UV-C mediated bimetallic Ag–ZnONPs (0.1/0.5). The present work highlights the positive effects of UV-C light on physico-chemical physiognomies as well as the clinical activities of NPs.

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Section: Introductionmentioning

confidence: 99%

Light Tailoring: Impact of UV-C Irradiation on Biosynthesis, Physiognomies, and Clinical Activities of Morus macroura-Mediated Monometallic (Ag and ZnO) and Bimetallic (Ag–ZnO) Nanoparticles

Anjum

Khan

Qamar

et al. 2021

IJMS

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“…In which nano silver increased antibacterial capabilities are being used by cosmetic companies in a variety of applications. Some companies are already selling underarm deodorants that promise to provide up to 24 hours antibacterial protection due to silver content [6]. Gold nanoparticles, like nano silver, is said to be very good at killing bacteria in the mouth and has also been studied [1].…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

“…Other form such as titanium oxide NPs, zinc oxide NPs, silica NPs, aluminium oxide NPs are widely used in cosmetic industries due their marked applications in skincare products. Apart from these, several nano forms of carbon such as fullerenes, nanodiamonds and nanotubes have remarkably applied in skin care and haircare products [6].…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

“…The effectiveness of skin care product can determine by the substances used and technology utilised to prepare them. A cosmetic product is made up of an active component and other substances that comprise the product's base, "vehicle", or presentation, such as creams, lotions, and gels [6].…”

Section: Skin Carementioning

confidence: 99%

“…Nanoparticles may cause environmental issues if exposed to water air and soil. Because of high reactivity, it may alter the biological properties and exploited in various application because of its unique features [6].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Trends in Cosmeceuticals Based Nanotechnology: Up-to-Date

Sadhu¹,

Singh²,

Kumari³

et al. 2021

JPRI

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The American physicist Richard Phillips Fenyman, first proposed the concept of nanotechnology in the year 1959. However, the researcher and professor (Tokyo University of Sciences) who actually coined the term ‘nanotechnology’ was Norio Taniguchi, in 1974. Now, to improve the efficacy of cosmetic and therapeutic applications in this field, the cosmetic industry is significantly embracing nanotechnology. The application of nanotechnology in the field of cosmeceuticals makes cosmetics very effective, providing better protection against UV rays, deeper penetration into the skin, long-lasting effects, higher colour, quality of finish and more. This review critically collects the latest updates regarding the use of nanomaterials for the preparation of cosmetics for pharmaceutical applications. In addition, this review provides a brief overview of almost all nano forms as cosmetic formulations different types, of cosmetics based on nanotechnology and patents.

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Nanomedicine for Diagnosis and Treatment of Atherosclerosis

Cheng,

Huang,

Chen

et al. 2023

Advanced Science

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With the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and the associated diseases have emerged as the leading cause of death. Due to their fascinating physical, chemical, and biological characteristics, nanomaterials are regarded as a promising tool to tackle enormous challenges in medicine. The emerging discipline of nanomedicine has filled a huge application gap in the atherosclerotic field, ushering a new generation of diagnosis and treatment strategies. Herein, based on the essential pathogenic contributors of atherogenesis, as well as the distinct composition/structural characteristics, synthesis strategies, and surface design of nanoplatforms, the three major application branches (nanodiagnosis, nanotherapy, and nanotheranostic) of nanomedicine in atherosclerosis are elaborated. Then, state‐of‐art studies containing a sequence of representative and significant achievements are summarized in detail with an emphasis on the intrinsic interaction/relationship between nanomedicines and atherosclerosis. Particularly, attention is paid to the biosafety of nanomedicines, which aims to pave the way for future clinical translation of this burgeoning field. Finally, this comprehensive review is concluded by proposing unresolved key scientific issues and sharing the vision and expectation for the future, fully elucidating the closed loop from atherogenesis to the application paradigm of nanomedicines for advancing the early achievement of clinical applications.

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The emerging role of nanotechnology in skincare

Cited by 159 publications

References 224 publications

Light Tailoring: Impact of UV-C Irradiation on Biosynthesis, Physiognomies, and Clinical Activities of Morus macroura-Mediated Monometallic (Ag and ZnO) and Bimetallic (Ag–ZnO) Nanoparticles

Light Tailoring: Impact of UV-C Irradiation on Biosynthesis, Physiognomies, and Clinical Activities of Morus macroura-Mediated Monometallic (Ag and ZnO) and Bimetallic (Ag–ZnO) Nanoparticles

Trends in Cosmeceuticals Based Nanotechnology: Up-to-Date

Nanomedicine for Diagnosis and Treatment of Atherosclerosis

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