Fear learning and generalization during pandemic fear: How COVID-19-related anxiety affects classical fear conditioning with traumatic film clips

Hauck, Alexander; Michael, Tanja; Sá, Diana S. Ferreira de

doi:10.1016/j.jpsychires.2022.07.068

Cited by 12 publications

(10 citation statements)

References 77 publications

(115 reference statements)

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“…Our current study extends the previous finding by showing that living with familiar non‐surgery cage‐mates reduces learning and memory impairment in young and old mice with surgery. Excessive anxiety is unhealthy and can impair learning and memory 5,6 . It is possible that the reduced learning and memory dysfunction of surgery mice living with familiar cage‐mates may be due to the attenuated anxiety in these surgery mice.…”

Section: Discussionmentioning

confidence: 99%

“…Excessive anxiety is unhealthy and can impair learning and memory. 5 , 6 It is possible that the reduced learning and memory dysfunction of surgery mice living with familiar cage‐mates may be due to the attenuated anxiety in these surgery mice.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with surgery often are anxious 4,5 . Anxiety can impair learning and memory 6 . It is not known whether anxiety during the perioperative period contributes to POCD.…”

Section: Introductionmentioning

confidence: 99%

“… 4 , 5 Anxiety can impair learning and memory. 6 It is not known whether anxiety during the perioperative period contributes to POCD. Our previous study has shown that mice with surgery are anxious and that living with familiar observers without surgery in the same cages reduces this anxiety.…”

Section: Introductionmentioning

confidence: 99%

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Familiar observers attenuate surgery‐induced neuroinflammation and cognitive dysfunction in mice

2023

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AimsPostoperative cognitive dysfunction (POCD) is a common complication associated with poor outcome. Our previous study has shown that living with familiar observers in the same cage reduces anxiety of mice with surgery. Anxiety can impair learning and memory. Thus, this study was designed to determine whether living with familiar observers attenuated the dysfunction of learning and memory of mice with surgery.MethodsSix‐ to eight‐week‐old CD‐1 male mice or 18‐month‐old C57BL/6 male mice had left carotid artery exposure under isoflurane anesthesia. They lived with non‐surgery male mice at 2 (number of surgery mice) to 3 (number of non‐surgery mice) ratio or with other surgery mice. Mice were subjected to light and dark box test 3 days after surgery to measure their anxiety levels and novel object recognition and fear conditioning tests from 5 days after surgery to measure their learning and memory. Blood and brain were harvested for biochemical analysis.ResultsLiving with familiar observers that lived with surgery mice for at least 2 weeks before the surgery and then after surgery reduced the anxiety and dysfunction of learning and memory in young adult male mice. Living with unfamiliar observers that lived with surgery mice after the surgery but not before the surgery did not have those effects on the mice with surgery. Living with familiar observers attenuated learning and memory dysfunction after surgery also in old male mice. Living with familiar observers attenuated inflammatory response in the blood and brain and the activation of the lateral habenula (LHb)‐ventral tegmental area (VTA) neural circuitry, which has been shown to be important for POCD. Wound infiltration with bupivacaine attenuated the activation of LHb‐VTA.ConclusionThese results suggest that living with familiar observers attenuates POCD and neuroinflammation, possibly via inhibiting the activation of the LHb‐VTA neural circuitry.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Patients with surgery often are anxious 4,5 . Anxiety can impair learning and memory 6 . It is not known whether anxiety during the perioperative period contributes to POCD.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Familiar observers attenuate surgery‐induced neuroinflammation and cognitive dysfunction in mice

2023

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“…Various international studies have reported an increase in mental health disorders among university students who, due to the pandemic, experience high levels of anxiety and depression ( 57 , 58 ), suicidal ideation ( 59 , 60 ), stress, fear ( 61 ), emotional, learning, financial, social, and technological impacts ( 62 ), changes in eating habits, sleep, lifestyle, and behavior ( 63 ), and nightmares ( 64 ). These factors impair academic performance ( 65 ).…”

Section: Post-covid-19 Pandemic: Diagnosis Of Mental Health In Chilea...mentioning

confidence: 99%

The challenges of mental health in Chilean university students

Beroíza-Valenzuela

2024

Front. Public Health

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Mental health is a crucial issue in Chile and worldwide, gaining even more relevance following social events in Chile in 2019, including the sociopolitical crisis and the COVID-19 pandemic. In Chile, over 20% of adolescents experience mental health problems such as anxiety, depression, and stress, with many going untreated due to limited access or the stigma associated with these issues. The COVID-19 pandemic has exacerbated this situation, with a 25% increase in the prevalence of anxiety and depression. The university population is particularly vulnerable to mental health challenges due to the unique pressures of the academic environment, including increased academic demands and the acquisition of university-related behaviors that can negatively impact physical and mental health, with notable gender differences. Effectively addressing these issues is essential for ensuring the emotional and psychological well-being of university students. Specific policies and programs are needed to address the mental health needs of university adolescents and ensure that they have access to mental health services required to navigate the challenges of daily life. A methodology reflective of the essayistic approach guides this exploration, which is characterized by critical reflection and structured argumentation.

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