Fe3O4@ZnS@Glycine nanoparticle as a novel microwave stimulus controlled drug release system

Abstract

The stimuli-responsive controlled drug delivery system is highly desirable for an efficient cancer treatment approach. Herein, we have successfully developed a novel multifunctional microwave stimulus controlled anticancer drug release system based on magnetic Fe 3 O 4 @-ZnS@Glycine nanoparticles. Fe 3 O 4 core has a high magnetization saturation value for drug targeting under foreign magnetic fields. ZnS shells can efficiently convert microwave energy into thermal energy for microwave-triggered drug release. The glycine-modified layer of nanoparticles provides active group (-NH 2 ) for the loading of drug molecules by hydrogen bond. The in vitro studies have clearly demonstrated the feasibility and advantage of the novel nanocarriers for remote-controlled drug release systems.Graphical Abstract We combined the advantages of ZnS nanoparticles with those of Fe 3 O 4 and glycine to create a new drug delivery system, which is capable of carrying drug molecules and triggered release of the drug by microwave treatment.