Preparation of multifunctional Fe3O4@ZnAl2O4:Eu3+@mSiO2–APTES drug-carrier for microwave controlled release of anticancer drugs

Bu, Yumei; Cui, Bin; Zhao, Weiwei; Yang, Zhenfeng

doi:10.1039/c7ra12004d

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…In a separate study, Yumei Bu and colleagues developed Fe 3 O4@ZnAl 2 O4:Eu 3+ @mSiO 2 -APTES for drug-delivery applications, harnessing the thermal responsiveness of ZnAl 2 O 4 :Eu 3+ . The study reported that 78.2% of the total drug was released in a controlled manner using on/off cycles of MW irradiation [18]. In a study by Chen et al, MW-responsive nanoparticles of mesoporous cobalt ferrite (H-mCo x Fe 3−x O 4 ) were used to encapsulate a chemotherapy drug called VP16.…”

Section: Introductionmentioning

confidence: 99%

Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin

Fatima,

Sabouni,

Husseini

et al. 2024

Nanomaterials

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Metal-organic frameworks (MOFs) are excellent candidates for a range of applications because of their numerous advantages, such as high surface area, porosity, and thermal and chemical stability. In this study, microwave (MW) irradiation is used as a novel stimulus in vitro controlled release of Doxorubicin (DOX) from two MOFs, namely Fe-BTC and MIL-53(Al), to enhance drug delivery in cancer therapy. DOX was encapsulated into Fe-BTC and MIL-53(Al) with drug-loading efficiencies of up to 67% for Fe-BTC and 40% for MIL-53(Al). Several characterization tests, including XRD, FTIR, TGA, BET, FE-SEM, and EDX, confirmed both MOF samples’ drug-loading and -release mechanisms. Fe-BTC exhibited a substantial improvement in drug-release efficiency (54%) when exposed to microwave irradiation at pH 7.4 for 50 min, whereas 11% was achieved without the external modality. A similar result was observed at pH 5.3; however, in both cases, the release efficiencies were substantially higher with microwave exposure (40%) than without (6%). In contrast, MIL-53(Al) exhibited greater sensitivity to pH, displaying a higher release rate (66%) after 38 min at pH 5.3 compared to 55% after 50 min at pH 7.4 when subjected to microwave irradiation. These results highlight the potential of both MOFs as highly heat-responsive to thermal stimuli. The results of the MTT assay demonstrated the cell viability across different concentrations of the MOFs after two days of incubation. This suggests that MOFs hold promise as potential candidates for tumor targeting. Additionally, the fact that the cells maintained their viability at different durations of microwave exposure confirms that the latter is a safe modality for triggering drug release from MOFs.

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Section: Introductionmentioning

confidence: 99%

Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin

Fatima,

Sabouni,

Husseini

et al. 2024

Nanomaterials

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“…The applicability of magnetic nanoparticles (MNPs) in therapy and diagnostics strongly depends on the particles' size, shape, surface properties and terminal functional groups [15]. Thus, the production of drugloaded MNPs is of great importance, but it often requires complex and costly technology [16]. Therefore, the search for novel methods which may simplify the preparation of magnetosensitive nanocomposites is still relevant.…”

Section: Introductionmentioning

confidence: 99%

Production of ibuprofen-magnetite nanocomposites by pulsed laser ablation

Gera

Kolumban

Ajtai

et al. 2021

J. Phys. D: Appl. Phys.

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We investigated the application of pulsed laser ablation (PLA) for the production of magnetic nanoparticles (MNPs)/drug nanocomposites. Magnetic drug delivery vehicles can provide a multifunctional theranostic platform and allow for a combination of diagnostics, monitoring and therapeutics. We applied nanosecond laser pulses at two different wavelengths (Nd:YAG laser, λ 1 = 532 nm/λ 2 = 1064 nm, FWHM = 6 ns) for the ablation of target tablets consisting of a mixture of ibuprofen (as a model drug) and magnetite NPs in various mass ratios. Fourier-transform infrared and Raman spectroscopy investigations of the ablated particles revealed that PLA induced no chemical changes in the pharmaceutical compound. The size distributions of the composite particles were established using a particle size analyzer (scanning mobility particle sizer), and 100-150 nm mean particle size values were obtained. SEM, energy dispersive x-ray spectroscopy and fast photography studies provided morphological and compositional information about the ablated particles. We demonstrated that PLA offers a simple and chemical free method for producing MNPs/drug nanocomposites, and it can be applied for the future development of new theranostic nanosystems.

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The enhanced galvanostatic and impedance studies of silver doped ZnAl2O4 anode material for Li/Na ion batteries

Vidya,

Manjunatha,

Ravuri

et al. 2024

Appl. Phys. A

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Preparation of multifunctional Fe₃O₄@ZnAl₂O₄:Eu³⁺@mSiO₂–APTES drug-carrier for microwave controlled release of anticancer drugs

Abstract: In this study, we prepared a carrier possessing a simple structure and composition, but with the microwave-targeted-fluorescence multifunctional properties.

Cited by 6 publications

References 25 publications

Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin

Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin

Production of ibuprofen-magnetite nanocomposites by pulsed laser ablation

The enhanced galvanostatic and impedance studies of silver doped ZnAl2O4 anode material for Li/Na ion batteries

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