In
this paper, we constructed a novel core–shell structured
nanocarrier used as a drug carrier to investigate the storage and
controllable release properties of the cancer chemotherapeutic drug
etoposide (VP16). The new composite nanocomposite composed of a mesoporous
silica shell with magnetic Fe3O4 core and ZnO
interlayer with a core–shell structure was prepared by a simple
process. The mesoporous nanocarrier possesses high surface area (643.9
m2/g), provides large accessible pore volume (0.32 cm3/g) for the adsorption of drug molecules, and has a high magnetization
saturation value (56.8 emu/g) for drug targeting under foreign magnetic
fields, and the ZnO interlayer acts as a good microwave absorber with
excellent microwave thermal response property for microwave-triggered
drug release (the VP16 release of over 85% under microwave discontinuous
irradiation outclasses the 14% within 10 h only stirring release).
This multifunctional system shows a good performance for targeting
delivery and controllable release of anticancer drugs based on all
the properties they possess.
Edited by Tamas DalmayKeywords: Spinocerebellar ataxia type 3/MachadoJoseph disease ATXN3 Cytotoxicity Neuronal intranuclear inclusion miR-25 Gene expression regulation a b s t r a c t MicroRNAs (miRNAs) have been reported to play significant roles in the pathogenesis of various polyQ diseases. This study aims to investigate the regulation of ATXN3 gene expression by miRNA. We found that miR-25 reduced both wild-type and polyQ-expanded mutant ataxin-3 protein levels by interacting with the 3 0 UTR of ATXN3 mRNA. miR-25 also increased cell viability, decreased early apoptosis, and downregulated the accumulation of mutant ataxin-3 protein aggregates in SCA3/ MJD cells. These novel results shed light on the potential role of miR-25 in the pathogenesis of SCA3/MJD, and provide a possible therapeutic intervention for this disorder.
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