(Fe)MIL-100-Met@alginate: a hybrid polymer–MOF for enhancement of metformin's bioavailability and pH-controlled release

Vahed, Tahereh Azizi; Naimi-Jamal, Mohammad Reza; Panahi, Leila

doi:10.1039/c8nj01946k

Cited by 27 publications

(11 citation statements)

References 48 publications

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“…Finally, as the degradation of MIL-101-NH2(Fe) took place, the amount of polymer adsorbed on the nanoMOFs remained constant, suggesting that it bound to newly formed sites during the degradation of the MOF structure ( Figure 4B, step 6). Azizi Vahed et al reported the preparation of a novel MOF: MIL-100-metformin(Fe), an antihyperglycemic agent used for the treatment of type II diabetes that also presents anti-cancer properties [63]. In the MOF structure, the metformin molecules are believed to coordinate iron ions, but without bridging two different ions.…”

Section: Non-covalent Attachmentmentioning

confidence: 99%

“…The coated nanoparticles were characterized by Fouriertransform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and x-ray diffraction (XRD) (indicating the MOF crystallinity is retained). The MIL-100-Metformin(Fe) nanoparticles were Azizi Vahed et al reported the preparation of a novel MOF: MIL-100-metformin(Fe), an antihyperglycemic agent used for the treatment of type II diabetes that also presents anti-cancer properties [63]. In the MOF structure, the metformin molecules are believed to coordinate iron ions, but without bridging two different ions.…”

Section: Non-covalent Attachmentmentioning

confidence: 99%

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Polymer/Metal Organic Framework (MOF) Nanocomposites for Biomedical Applications

et al. 2020

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The utilization of polymer/metal organic framework (MOF) nanocomposites in various biomedical applications has been widely studied due to their unique properties that arise from MOFs or hybrid composite systems. This review focuses on the types of polymer/MOF nanocomposites used in drug delivery and imaging applications. Initially, a comprehensive introduction to the synthesis and structure of MOFs and bio-MOFs is presented. Subsequently, the properties and the performance of polymer/MOF nanocomposites used in these applications are examined, in relation to the approach applied for their synthesis: (i) non-covalent attachment, (ii) covalent attachment, (iii) polymer coordination to metal ions, (iv) MOF encapsulation in polymers, and (v) other strategies. A critical comparison and discussion of the effectiveness of polymer/MOF nanocomposites regarding their synthesis methods and their structural characteristics is presented.

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Section: Non-covalent Attachmentmentioning

confidence: 99%

Section: Non-covalent Attachmentmentioning

confidence: 99%

Polymer/Metal Organic Framework (MOF) Nanocomposites for Biomedical Applications

et al. 2020

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“…Upon exposure to aqueous sodium citrate solution, the alginate coating was degraded, and the ethylene was gradually released from the MOF pore space. Similarly, the pH-controlled drug release of metformin was achieved by Naimi-Jamal and coworkers using alginate-coated (Fe)MIL-100 . In an alternate method by Huang, Huo, Xu, and coworkers, doxorubicin drug molecules were encapsulated in selenium-containing polymer micelles, which were then trapped within ZIF-8 frameworks .…”

Section: Functional Applications Of Polymer/mof/moc Hybrid Materialsmentioning

confidence: 99%

Coordination-Driven Self-Assembly in Polymer–Inorganic Hybrid Materials

Pastore

Cook

2020

Chem. Mater.

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“…Nanosized MIL-100(Fe) is widely reported to be unstable [ 27 , 28 ]. Surface modification strategies were developed to prevent MOFs from aggregation, including coating with lipids [ 28 , 29 , 30 ], polymers [ 31 , 32 , 33 ], and cyclodextrins (CDs) [ 27 , 34 , 35 ]. A particular focus was on nanoMOFs’ surface engineering with CD derivatives [ 27 , 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Acetic Acid-Modulated Room Temperature Synthesis of MIL-100 (Fe) Nanoparticles for Drug Delivery Applications

Ding

Qiu

Rouzière

et al. 2023

IJMS

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Due to their flexible composition, large surface areas, versatile surface properties, and degradability, nanoscale metal organic frameworks (nano MOFs) are drawing significant attention in nanomedicine. In particular, iron trimesate MIL-100 (Fe) is studied extensively in the drug delivery field. Nanosized MIL-100 (Fe) are obtained mostly by microwave-assisted synthesis. Simpler, room-temperature (RT) synthesis methods attract growing interest and have scale-up potential. However, the preparation of RT MIL100 is still very challenging because of the high tendency of the nanoparticles to aggregate during their synthesis, purification and storage. To address this issue, we prepared RT MIL100 using acetic acid as a modulator and used non-toxic cyclodextrin-based coatings to ensure stability upon storage. Hydrodynamic diameters less than 100 nm were obtained after RT synthesis, however, ultrasonication was needed to disaggregate the nanoparticles after their purification by centrifugation. The model drug adenosine monophosphate (AMP) was successfully encapsulated in RT MIL100 obtained using acetic acid as a modulator. The coated RT MIL100 has CD-exhibited degradability, good colloidal stability, low cytotoxicity, as well as high drug payload efficiency. Further studies will focus on applications in the field of cancer therapy.

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(Fe)MIL-100-Met@alginate: a hybrid polymer–MOF for enhancement of metformin's bioavailability and pH-controlled release

Abstract: Metformin hydrochloride (Met) was combined with iron(iii) chloride and trimesic acid (1,3,5-benzene tricarboxylic acid, BTC) as an organic linker in a short and simple method, providing a MOF in which the drug is a part of the constituent.

Cited by 27 publications

References 48 publications

Polymer/Metal Organic Framework (MOF) Nanocomposites for Biomedical Applications

Polymer/Metal Organic Framework (MOF) Nanocomposites for Biomedical Applications

Coordination-Driven Self-Assembly in Polymer–Inorganic Hybrid Materials

Acetic Acid-Modulated Room Temperature Synthesis of MIL-100 (Fe) Nanoparticles for Drug Delivery Applications

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