No abstract

Metformin hydrochloride (Met) was combined with iron(iii) chloride and trimesic acid (1,3,5-benzene tricarboxylic acid, BTC) as an organic linker in a short and simple method, providing a MOF in which the drug is a part of the constituent.

In this work, we succeeded to synthesis enol carbamates using modified MOFs in short times and excellent yields. In this procedure we utilized 1, 3-dicarbonyl compounds, DMF, TBHP as oxidant and MOFs as catalyst. Products were obtained with excellent yield and in short times.

Herein we used MOFs as a platform for controlled drug release and reported a technique, which pharmaceutical agents are encapsulated in a zinc zeolitic imidazolate framework (ZIF-8). In this work, metformin, an oral antihyperglycemic agent for the treatment of type II diabetes trapped inside the ZIF-8 pores through a mechanochemical ball-milling technique. Due to having regular porosity and zinc ions, ZIF-8 could help to better absorption of metformin. The synthesis of the MOF and the encapsulating process of the drug were performed by using a convenient solvent-free one pot technique. It was shown that with this approach, metformin is released in the stomach via a controlled manner over a longer time that leads to increases of metformin bioavailability.