FDG-Anorectic Parathyroid Carcinoma With FDG-Avid Bone Metastasis on PET/CT Images

Abstract

A 53-year-old man complained of aggravated left hip pain of more than 2 months. Whole-body (18)F-FDG PET/CT revealed only 1 hypermetabolic lesion in the left ilium. Histopathologic examination of the lesion suggested metastatic disease. Blood tests documented mildly elevated blood calcium and parathyroid hormone. Subsequent neck ultrasonography, contrast-enhanced CT, and dual-phase scintigraphy with (99m)Tc-MIBI showed a right parathyroid tumor, which was confirmed to be a parathyroid carcinoma postoperatively. We report a case of parathyroid carcinoma rarely encountered with a FDG-negative primary but a FDG-positive metastasis on PET/CT images.

Circulating Tumor Cell Analysis in Preclinical Mouse Models of Metastasis

“…PET/CT can take advantage of specific PET properties such as high sensitivity (depending on which tracer is used) and can reduce the risk of false-positives by using CT data to confirm the morphology of scintigraphic lesions [ 38 ]. PET/CT imaging can be used to assess a large variety of metastatic sites including lymph nodes, lungs, bones, and liver [ 39 , 40 , 41 , 42 ].…”

18Fluorocholine PET/CT in parathyroid carcinoma: a new tool for disease staging?

“…The 18 F-choline PET/CT detected one left soft tissue nodule in the neck (D; axial fused image, red arrow) and one cerebral frontal lesion confirmed to be local recurrence and brain metastases, both missed at 18FDG PET/CT. On the other hand 18 F-choline PET/CT missed one liver metastasis due to physiological liver uptake and two bone lesions located in the left pelvis detected by 18FDG PET/CT (C; fused axial image, white arrow) [4]. All lesions showed a very faint uptake on WB 99mTcMIBI scan.…”

A Case of Brown Tumor on 68Ga-DOTATATE PET/CT and 18F-FDG PET/CT

“…When secondary to parathyroid carcinoma, it creates a clinical dilemma 4 . Both brown tumor and bone metastasis from parathyroid carcinoma have been reported showing high 18 F-FDG uptake, 4–8 whereas only one case report describes a brown tumor with high 68 Ga-DOTATATE avidity 9 . Our case highlights the possibility of brown tumor as a cause of 68 Ga-DOTATATE or 18 F-FDG–avid lesion in the setting of parathyroid carcinoma.…”