A Case of Brown Tumor on 68Ga-DOTATATE PET/CT and 18F-FDG PET/CT

Yao, Xilan; Ou, Xiaohong

doi:10.1097/rlu.0000000000003887

Cited by 6 publications

(8 citation statements)

References 9 publications

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“…Most brown tumors grow slowly, usually in long bones, and typically provoke symptoms when local compression or pathological fractures occur 1,2 . Only few literatures have reported high uptake of brown tumors on 68 Ga-DOTATATE PET/CT, suggesting that they may overexpress somatostatin receptors 3,4 . Our case illustrates that brown tumor can also show high activity on 99m Tc-HYNIC-TOC scintigraphy.…”

mentioning

confidence: 61%

“…1,2 Only few literatures have reported high uptake of brown tumors on 68 Ga-DOTATATE PET/CT, suggesting that they may overexpress somatostatin receptors. 3,4 Our case illustrates that brown tumor can also show high activity on 99m Tc-HYNIC-TOC scintigraphy. Somatostatin receptor imaging is recommended in patients with suspected TIO to detect and locate the primary and recurrent causative tumors.…”

Section: Figurementioning

confidence: 75%

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Increased Uptake of Brown Tumor in 99mTc-HYNIC-TOC Scintigraphy Mimicking Postoperative Recurrence of Tumor-Induced Osteomalacia

Zhang,

Wang,

Liu

et al. 2023

Clin Nucl Med

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A 61-year-old man underwent a resection of tumor in the left tibia that caused osteomalacia 11 years ago. Postoperative bone pain and fatigue symptoms were briefly relieved but then recurred. To identify potential recurrent tumors, 99mTc-HYNIC-TOC scintigraphy was performed. Images revealed an osteolytic lesion in the right tibia with increased uptake. The lesion was subsequently resected, which pathologically proved a brown tumor. Symptoms of bone pain and weakness caused by osteomalacia did not relieve 4 months after the operation. Here, we present a rare case of brown tumor with high activity on 99mTc-HYNIC-TOC SPECT/CT, mimicking a culprit tumor of osteomalacia.

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mentioning

confidence: 61%

Section: Figurementioning

confidence: 75%

Increased Uptake of Brown Tumor in 99mTc-HYNIC-TOC Scintigraphy Mimicking Postoperative Recurrence of Tumor-Induced Osteomalacia

Zhang,

Wang,

Liu

et al. 2023

Clin Nucl Med

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“…[5][6][7][8][9] Whole-body 18 F-fluorocholine PET/CT 10 offers visualization of parathyroid adenomas and brown tumors in "one-stop" imaging. [11][12][13][14][15]…”

Section: Figurementioning

confidence: 99%

“…Brown tumors are a rare complication of severe hyperparathyroidism and may be overlooked on bone scintigraphy [5][6][7][8][9]. Whole-body 18 F-fluorocholine PET/CT 10 offers visualization of parathyroid adenomas and brown tumors in "one-stop" imaging [11][12][13][14][15].…”

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confidence: 99%

Localization of Brown Tumors With 18F-Fluorocholine PET/CT Imaging in Severe Primary Hyperparathyroidism

et al. 2023

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We present the case of a 68-year-old woman with a painful tibial tumor and fatigue. Histology and laboratory studies were consistent with a brown tumor secondary to initially unrecognized, severe primary hyperparathyroidism. 18F-fluorocholine PET/CT revealed a large hypermetabolic parathyroid mass and multiple bone foci considered as brown tumors. Unilateral neck exploration confirmed a large parathyroid adenoma. Serum calcium and parathyroid hormone levels normalized quickly, and symptoms subsided gradually after parathyroidectomy. Brown tumors are a rare complication of severe hyperparathyroidism. 18F-fluorocholine PET/CT allows the localization of parathyroid adenomas and brown tumors, and can be used as a single imaging modality.

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“…6 Many other nonneuroendocrine tumor etiologies, benign and malignant, have been shown to take up 68 Ga-DOTATATE. [7][8][9][10][11][12][13][14] Although one can conclude the need for further investigation of increased 68 Ga-DOTATATE uptake by the uterus, false-positive results are possible. Increased uptake has been reported with benign tumors and normal tissues, including the uterus.…”

Section: Figurementioning

confidence: 99%

Synchronous Endometrial Cancer Detected on 68Ga-DOTATATE PET/CT

Mohammadinejad,

Kim,

Koshevarova

et al. 2023

Clin Nucl Med

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A 50-year-old woman with history of metastatic neuroendocrine tumor underwent a follow-up PET/CT with 68Ga-DOTATATE. An enlarged uterus with diffuse increased uptake warranted further investigation with an MRI that showed mass-like thickening of the endometrium, T2 hyperintensity, lobulated contour, and invasion of more than 50% of the myometrium. Biopsy revealed endometrial carcinoma with mucinous features. Mild to moderate uptake of the 68Ga-DOTATATE by the uterus can be a normal physiological finding; however, it should prompt further investigation, particularly in a postmenopausal woman with concerning imaging or clinical findings.

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A Case of Brown Tumor on 68Ga-DOTATATE PET/CT and 18F-FDG PET/CT

Cited by 6 publications

References 9 publications

Increased Uptake of Brown Tumor in 99mTc-HYNIC-TOC Scintigraphy Mimicking Postoperative Recurrence of Tumor-Induced Osteomalacia

Increased Uptake of Brown Tumor in 99mTc-HYNIC-TOC Scintigraphy Mimicking Postoperative Recurrence of Tumor-Induced Osteomalacia

Localization of Brown Tumors With 18F-Fluorocholine PET/CT Imaging in Severe Primary Hyperparathyroidism

Synchronous Endometrial Cancer Detected on 68Ga-DOTATATE PET/CT

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