18Fluorocholine PET/CT in parathyroid carcinoma: a new tool for disease staging?

Deandreis, Désirèe; Terroir, Marie; Ghuzlan, Abir Al; Berdelou, A.; Lacroix, Ludovic; Bidault, François; Troalen, Frédéric; Hartl, Dana M.; Lumbroso, J.; Baudin, Éric; Schlumberger, Martin; Leboulleux, Sophie

doi:10.1007/s00259-015-3130-6

Cited by 39 publications

(20 citation statements)

References 4 publications

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“…Recent studies have indicated that 18 F-Fluorocholine PET/CT had a better diagnostic accuracy than 99m Tc-MIBI SPECT/CT for localization of parathyroid adenoma (21)(22)(23), especially in the detection of small parathyroid adenomas. However, few cases of 18 F-fluorocholine PET/CT in parathyroid carcinoma have been reported until now (24,25). Therefore, the value of 18 F-fluorocholine PET/CT for differentiating parathyroid carcinoma from adenoma is still uncertain, and needs to be further explored in a larger cohort of patients with PHPT.…”

Section: Discussionmentioning

confidence: 99%

Semi-quantitative analysis of 99mTc-sestamibi retention level for preoperative differential diagnosis of parathyroid carcinoma

Zhang¹,

Sun²,

Rui³

et al. 2019

Quant. Imaging Med. Surg.

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Background: To investigate the role of 99m Tc-labeled sestamibi (99m Tc-MIBI) retention level in the assessment of malignant potential of parathyroid lesions. Methods: Twenty patients with parathyroid carcinomas and forty controls with benign parathyroid lesions who underwent preoperatively 99m Tc-MIBI dual-phase planar and SPECT/CT imaging were retrospectively enrolled in this study. The mean and peak of retention index (RI mean and RI peak) were measured for evaluating the retention level of 99m Tc-MIBI in the parathyroid lesions. Diagnostic accuracies of RI for differentiating malignant parathyroid lesions from benign ones were assessed by receiver operating characteristic analyses (area under the curve; AUC). Results: RI peak (AUC =0.87, P<0.001) and RI mean (AUC =0.78, P<0.001) showed significant difference between the malignant and benign lesions. The diagnostic sensitivity, specificity, positive and negative predictive values, accuracy of RI peak were respectively 80.0%, 85.0%, 72.7%, 89.5% and 83.3% when its cutoff value was −19.03%. In addition, the level of serum parathyroid hormone (PTH) slightly correlated with RI peak (r=0.260, P=0.044) or RI mean (r=0.281, P=0.029). Conclusions: Parathyroid carcinomas have higher retention level of 99m Tc-MIBI than benign parathyroid lesions. RI peak may contribute to preoperative differential diagnosis of parathyroid carcinoma.

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Section: Discussionmentioning

confidence: 99%

Semi-quantitative analysis of 99mTc-sestamibi retention level for preoperative differential diagnosis of parathyroid carcinoma

Zhang¹,

Sun²,

Rui³

et al. 2019

Quant. Imaging Med. Surg.

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“…Another diagnostic option which may be useful in the localization of distant metastases is 18 F-FDG PET scanning [18,23,24]. Using this technique, several imaging signs have been proposed to raise the suspicion of PC [11,12,16,18,23,25].…”

Section: Discussionmentioning

confidence: 99%

Rak przytarczycy jako przedoperacyjny dylemat diagnostyczny – opis przypadku i przegląd piśmiennictwa

Listewnik

Miazgowski

Borowiecki

et al. 2017

Pomeranian J Life Sci

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Introduction: Parathyroid carcinoma is the least common endocrine-related malignancy and accounts for less than 1% of all cases of primary hyperparathyroidism. In comparison to benign parathyroid adenoma, the clinical signs (including the presence of a tumour with regional or distant nodal involvement), biochemical abnormalities and metabolic activity are usually more expressed in parathyroid carcinoma. In the presented case report, there were no typical signs and symptoms suggesting the preoperative diagnosis of parathyroid carcinoma. Case report: The case was a 52-year-old woman with a history of recurrent renal stones, moderate hypertension, increased total and ionized calcium, low phosphorus, and increased intact parathyroid hormone. The clinical picture and imaging techniques (ultrasonography and SPECT/CT scintigraphy) suggested parathyroid adenoma. However, histological examination of the removed tumour revealed parathyroid carcinoma. Reoperation showed no regional lymph nodes involvement. After 12 months, normalisation of biochemical parameters and reduction of blood pressure from moderate grade to mild hypertension grade was achieved. Conclusions: 1. In patients with parathyroid carcinoma-associated hyperparathyroidism, successful surgical treatment not only restores serum calcium, phosphorus and parathyroid hormone levels, but may also improve blood pressure control. 2. Parathyroid carcinoma may demonstrate faint metabolic activity in the SPECT/CT study, and its biochemical secretion of parathyroid hormone may be placed in ranges more characteristic for benign parathyroid pathology. Keywords: parathyroid neoplasms; primary hyperparathyroidism; radionuclide imaging; ultrasonography; surgery; blood pressure.ABSTRAKT Wstęp: Rak przytarczycy jest jednym z rzadziej występujących nowotworów układu endokrynnego i odpowiada za mniej niż 1% wszystkich przypadków pierwotnej nadczynności przytarczyc. W porównaniu do zmian łagodnych, objawy kliniczne (m.in. obecność guza z zajęciem okolicznych węzłów chłonnych lub odległych przerzutów), parametry biochemiczne i aktywność metaboliczna raka przytarczycy są z reguły bardziej widoczne. W przedstawionym przypadku nie było objawów, które uzasadniałyby przedoperacyjne rozpoznanie raka przytarczycy. Opis przypadku: Przedstawiono przypadek 52-letniej pacjentki z nawrotowa kamicą nerkową, umiarkowanym nadciśnie-niem tętniczym, podwyższonym stężeniem wapnia całkowi-tego i zjonizowanego, niskim stężeniem potasu i podwyższo-nym poziomym kompletnego parathormonu. Obraz kliniczny i badania obrazowe (badanie ultrasonograficzne, scyntygrafia SPECT/CT) wskazywały na gruczolaka przytarczycy, jednakże za pomocą badania histopatologicznego usuniętej zmiany wykazano raka przytarczycy. Podczas reoperacji nie stwierdzono zajęcia okolicznych węzłów chłonnych. Uzyskano normalizację parametrów biochemicznych i redukcję nadciśnie-nia tętniczego z umiarkowanego do łagodnego stopnia podczas rocznej obserwacji chorej. Wnioski: 1. U pacjentów z pierwotną nadczynnością przytarczyc spowodow...

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“…Anecdotally, there are single scans reported as falsely negative in recurrent parathyroid carcinoma but a systematic study is warranted to clarify if these scans show any added benefit compared to other studies discussed above. 18 F-choline PET/CT, which is an indicator of lipid synthesis, has shown promise in detecting benign parathyroid adenomas but its utility in localizing initial or recurrent parathyroid carcinoma is unknown; only case reports have shown some promise thus far (Deandreis et al 2015, Morand et al 2018.…”

Section: Imagingmentioning

confidence: 99%

HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: New and future perspectives for parathyroid carcinoma

Perrier

Arnold

Costa-Guda

et al. 2020

Endocrine-Related Cancer

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This report summarizes published data on parathyroid cancer, with the inclusion of topics discussed at MEN2019: 16th International Workshop on Multiple Endocrine Neoplasia, 27–29 March 2019, Houston, TX, USA. An expert panel on parathyroid cancer was constituted by the Steering Committee to address key questions in the field. The objectives were to recap open forum discussion of interested parties from multiple disciplines. The expert panel met in a closed session to consult on the data to be highlighted on the evidence-based results and on the future directions. Preceding the Conference, members of the expert panel conducted an extensive literature search. All presentations were based upon the best peer-reviewed information taking into account the historical and current literature. Questions were developed by the expert panel on parathyroid carcinoma. A comprehensive literature search for relevant studies was undertaken. This report represents the expert panel’s synthesis of the conference material placed in a context designed to be relevant to clinicians and those engaged in cutting-edge studies of parathyroid carcinoma. This document not only provides a summary of our current knowledge but also places recent advances in its management into a context that should enhance future advances in our understanding of parathyroid carcinoma.

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18Fluorocholine PET/CT in parathyroid carcinoma: a new tool for disease staging?

Cited by 39 publications

References 4 publications

Semi-quantitative analysis of 99mTc-sestamibi retention level for preoperative differential diagnosis of parathyroid carcinoma

Semi-quantitative analysis of 99mTc-sestamibi retention level for preoperative differential diagnosis of parathyroid carcinoma

Rak przytarczycy jako przedoperacyjny dylemat diagnostyczny – opis przypadku i przegląd piśmiennictwa

HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: New and future perspectives for parathyroid carcinoma

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