Fatty acids and their lipid mediators in the induction of cellular apoptosis in cancer cells

Biswas, Pritam; Datta, Chandreyee; Rathi, Parul; Bhattacharjee, A.

doi:10.1016/j.prostaglandins.2022.106637

Cited by 22 publications

(14 citation statements)

References 170 publications

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“…A study has demonstrated that the species Anaeroglobus geminatus are associated with the four lipid mediators in human periodontitis ( Lee et al., 2021 ). To the best of our knowledge, inflammation is a hallmark of cancer, and the level of lipid mediators has a relationship with different cancers such as oral cancer, gastric cancer, melanomas, pancreatic cancer, colon cancer, liver cancer, and lung cancer ( Sulciner et al., 2018 ; Biswas et al., 2022 ). Therefore, we hypothesized that variation in the species Anaeroglobus geminatus might have a relationship with cancer through lipid mediator levels.…”

Section: Discussionmentioning

confidence: 99%

Saliva microbiome changes in thyroid cancer and thyroid nodules patients

Jiao

Zheng

Xia

et al. 2022

Front. Cell. Infect. Microbiol.

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ObjectiveThyroid disease has been reported to associate with gut microbiota, but the effects of thyroid cancer and thyroid nodules on the oral microbiota are still largely unknown. This study aimed to identify the variation in salivary microbiota and their potential association with thyroid cancer and thyroid nodules.MethodsWe used 16S rRNA high-throughput sequencing to examine the salivary microbiota of thyroid cancer patients (n = 14), thyroid nodules patients (n = 9), and healthy controls (n = 15).ResultsThe alpha-diversity indices Chao1 and ACE were found to be relatively higher in patients with thyroid cancer and thyroid nodules compared to healthy controls. The beta diversity in both the thyroid cancer and thyroid nodules groups was divergent from the healthy control group. The genera Alloprevotella, Anaeroglobus, Acinetobacter, unclassified Bacteroidales, and unclassified Cyanobacteriales were significantly enriched in the thyroid cancer group compared with the healthy control group. In contrast, the microbiome of the healthy controls was mainly composed of the genera Haemophilus, Lautropia, Allorhizobium Neorhizobium Pararhizobium Rhizobium, Escherichia Shigella, and unclassified Rhodobacteraceae. The thyroid nodules group was dominated by genre uncultured Candidatus Saccharibacteria bacterium, unclassified Clostridiales bacterium feline oral taxon 148, Treponema, unclassified Prevotellaceae, Mobiluncus, and Acholeplasma. In contrast, the genera unclassified Rhodobacteraceae and Aggregatibacter dominated the healthy control group. The study also found that clinical indicators were correlated with the saliva microbiome.ConclusionThe salivary microbiota variation may be connected with thyroid cancer and thyroid nodules.

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Section: Discussionmentioning

confidence: 99%

Saliva microbiome changes in thyroid cancer and thyroid nodules patients

Jiao

Zheng

Xia

et al. 2022

Front. Cell. Infect. Microbiol.

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“…These effects of KD could therefore be interpreted as beneficial to counteract tumor stem cells that are reliant on glycophospholipids. 5 Many tumor types are more dependent on conditionally essential amino acids, and, especially, branched-chain amino acids, in order to keep up with the metabolic demands of their highly proliferative growth. 6 KDs in this study induced significant decreases in the AA valine and methionine, both of which have previously been implicated as conditionally essential AA in tumours.…”

Section: F I G U R E 3 Continuedmentioning

confidence: 99%

“…Karin Allenspach 1 Dana C. Borcherding 2 Chelsea A. Iennarella-Servantez 2,3 Allison P. Mosichuk 1 Todd Atherly 1 Dipak Kumar Sahoo 2 Aarti Kathrani 3 Jan S. Suchodolski 4 Agnes Bourgois-Mochel 1 Mariana Rossoni Serao 5 Nick V. Serao 5 Auriel Willette 6 Beatriz Agulla Perez 1 Vojtech Gabriel…”

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confidence: 99%

Ketogenic diets in healthy dogs induce gut and serum metabolome changes suggestive of anti‐tumourigenic effects: A model for human ketotherapy trials

Allenspach

Borcherding

Iennarella-Servantez

et al. 2022

Clinical & Translational Med

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“…Most of the endogenous agonists of PPAR-γ are either polyunsaturated fatty acids (PUFAs) or their derivatives. These compounds are a part of fatty acid metabolism [ 18 ]. In turn, receptors for the named compounds, including PPAR-γ, are often referred to as sensors of fatty acids [ 19 ].…”

Section: Interaction Of Ppar-γ With Ligandsmentioning

confidence: 99%

The Role of Transcription Factor PPAR-γ in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells

Соболев

Tchepourina

Korsunskaya

et al. 2022

IJMS

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The peroxisome proliferator-activated receptor PPAR-γ is one of three PPAR nuclear receptors that act as ligand-activated transcription factors. In immune cells, the skin, and other organs, PPAR-γ regulates lipid, glucose, and amino acid metabolism. The receptor translates nutritional, pharmacological, and metabolic stimuli into the changes in gene expression. The activation of PPAR-γ promotes cell differentiation, reduces the proliferation rate, and modulates the immune response. In the skin, PPARs also contribute to the functioning of the skin barrier. Since we know that the route from identification to the registration of drugs is long and expensive, PPAR-γ agonists already approved for other diseases may also represent a high interest for psoriasis. In this review, we discuss the role of PPAR-γ in the activation, differentiation, and proliferation of skin and immune cells affected by psoriasis and in contributing to the pathogenesis of the disease. We also evaluate whether the agonists of PPAR-γ may become one of the therapeutic options to suppress the inflammatory response in lesional psoriatic skin and decrease the influence of comorbidities associated with psoriasis.

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Fatty acids and their lipid mediators in the induction of cellular apoptosis in cancer cells

Cited by 22 publications

References 170 publications

Saliva microbiome changes in thyroid cancer and thyroid nodules patients

Saliva microbiome changes in thyroid cancer and thyroid nodules patients

Ketogenic diets in healthy dogs induce gut and serum metabolome changes suggestive of anti‐tumourigenic effects: A model for human ketotherapy trials

The Role of Transcription Factor PPAR-γ in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells

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