Fatty acid composition of adipose tissue in aged rats: Effects of dietary restriction and exercise

Bailey, James; Walker, Esteban; Beauchene, Roy E.

doi:10.1016/0531-5565(93)90031-8

Cited by 19 publications

(15 citation statements)

References 25 publications

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“…Consistent with our previous findings (12,21) and those of others (36)(37)(38), adipose FA composition reflected the variations in dietary fat. Conversely, ER reduced adipose concentrations of 16:0, 16:1 (n-7), and 18:1 (n-9) in all depots studied, with the exception of Pr adipose from animals fed BT.…”

Section: Discussionsupporting

confidence: 81%

“…The present data do not support this finding, but the shorter feeding trial may explain these differences. In contrast, ER increased the concentration of 18:2 (n-6) in adipose tissues of our animals, whereas Bailey et al (38) found levels of 18:1 (n-9) to be elevated. Interestingly, Pr tissue from animals fed BT had a similar FA composition to those of Bailey et al (38).…”

Section: Discussioncontrasting

confidence: 50%

“…In contrast, ER increased the concentration of 18:2 (n-6) in adipose tissues of our animals, whereas Bailey et al (38) found levels of 18:1 (n-9) to be elevated. Interestingly, Pr tissue from animals fed BT had a similar FA composition to those of Bailey et al (38). This is likely related to the similarities in the FA profile of BT with the chow used in the previous study.…”

Section: Discussioncontrasting

confidence: 50%

“…These differences were the result of the high PUFA content of those fats. Tissue-specific differences in FA composition have been demonstrated by Bailey et al (38) in rats fed chow AL or food-restricted by alternate day feeding for 28 months. The major FA profile of the rodent chow was as follows: 16:0, 18:0, 18:1 (n-9), and 18:2 (n-6), with concentrations of 20.5%, 9.3%, 30.5%, and 27.3%, respectively.…”

Section: Discussionmentioning

confidence: 92%

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Effects of dietary fat type and energy restriction on adipose tissue fatty acid composition and leptin production in rats

Hynes

Heshka

Chadee

et al. 2003

Journal of Lipid Research

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To investigate whether dietary fatty acid (FA) composition and energy restriction (ER) interactively influence obese ( ob ) gene expression, rats consumed diets containing beef tallow, safflower, or fish oil ad libitum (AL) or at 60% AL intake. Circulating leptin concentrations were higher ( P Ͻ 0.0001) after AL feeding, but were not influenced by dietary fat. ER decreased ( P Ͻ 0.0001) weight gain and visceral adipose weight, which were positively correlated ( r ‫؍‬ 0.40 P Ͻ 0.001, r ‫؍‬ 0.58 P Ͻ 0.0001) with circulating leptin levels. Visceral adipose ob mRNA levels were greater in animals fed unsaturated fats, particularly safflower oil, which had the highest ob mRNA levels. Circulating leptin levels did not parallel ob mRNA levels, except for the greater abundance detected in AL adipose in comparison to ER animals. In addition, visceral FA profiles reflected dietary fat source and were influenced by an interaction of dietary fat and energy. These data demonstrate that dietary fat, particularly from a plant or marine source, and ER interactively influence ob mRNA levels; however, alterations in ob mRNA do not confer changes in circulating leptin, with the exception of ER, which is a key determinant. Thus, dietary intake is an important regulator of leptin production; however, the significance of these modest changes in diet-induced obese animals requires further study.

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Section: Discussionsupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 50%

Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 92%

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Effects of dietary fat type and energy restriction on adipose tissue fatty acid composition and leptin production in rats

Hynes

Heshka

Chadee

et al. 2003

Journal of Lipid Research

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“…Although there have been several studies addressing the effect of exercise training on the fatty acid profile of adipose tissue (Allard et al 1973;Bailey et al 1993;Danner et al 1984;Rocquelin and Juaneda 1981;Sˇimko et al 1970;Sutherland et al 1981; Thorling and Overvad 1994;Wirth et al 1980), again, a clear answer is missing. Except for Sˇimko et al (1970), who separated TG, all studies have examined total lipids of adipose tissue.…”

Section: Introductionmentioning

confidence: 93%

Effect of exercise training on the fatty acid composition of lipid classes in rat liver, skeletal muscle, and adipose tissue

et al. 2005

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The aim of the present study was to examine the effects of 8 weeks of exercise training on the fatty acid composition of phospholipids (PL) and triacylglycerols (TG) in rat liver, skeletal muscle (gastrocnemius medialis), and adipose tissue (epididymal and subcutaneous fat). For this purpose, the relevant tissues of 11 trained rats were compared to those of 14 untrained ones. Training caused several significant differences of large effect size in the concentrations and percentages of individual fatty acids in the aforementioned lipid classes. The fatty acid composition of liver PL, in terms of both concentrations and percentages, changed with training. The TG content of muscle and subcutaneous adipose tissue decreased significantly with training. In contrast to the liver, where no significant differences in the fatty acid profile of TG were found, muscle underwent more significant differences in TG than PL, and adipose tissue only in TG. Most differences were in the same direction in muscle and adipose tissue TG, suggesting a common underlying mechanism. Estimated fatty acid elongase activity was significantly higher, whereas Delta(9)-desaturase activity was significantly lower in muscle and adipose tissue of the trained rats. In conclusion, exercise training modified the fatty acid composition of liver PL, muscle PL and TG, as well as adipose tissue TG. These findings may aid in delineating the effects of exercise on biological functions such as membrane properties, cell signaling, and gene expression.

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Adiponectin is associated with serum and adipose tissue fatty acid composition in rats

Heredia

Sánchez

Priego

et al. 2009

J Endocrinol Invest

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The objective of the present work is to analyse the relationships between changes in adiponectin and fatty acid composition in serum and adipose tissue in rats. Samples from serum and different adipose depots (periovarian, mesenteric and subcutaneous) were obtained from ageing rats (14- and 20-month-old) to determine fatty acid composition (gasliquid chromatography). In serum, insulin (radioimmunoassay) and adiponectin levels (enzyme-linked immunosorbent assay) were also measured, while adiponectin gene expression was analysed (real time-qPCR) in all fat depots. There were significant age-related reductions in adipose tissue saturated (SFA) and trans fatty acids and increases in monounsaturated fatty acids in parallel with diminished adiponectin expression in periovarian and mesenteric adipose tissue (p<0.05). Age-independent negative correlations were found between adiponectin gene expression in mesenteric adipose tissue and C12:0, C14:0 and C18:2 trans fatty acids (p<0.05). There was a positive association between serum adiponectin and adipose tissue oleic acid, while palmitoleic acid was negatively associated with adiponectin expression and positively correlated with insulin concentration. For the first time, positive relationships are reported between the proportion of n-6 polyunsaturated fatty acids (PUFA) in adipose tissue and adiponectin concentration and expression. In summary, adiponectin expression and serum levels are associated with fatty acid composition, with SFA, trans and palmitoleic fatty acids appearing as negative markers for adiponectin, and oleic acid and n-6 PUFA as positive ones. In addition, most associations were found in the visceral depots, highlighting the importance of visceral fat in the metabolic status.

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Fatty acid composition of adipose tissue in aged rats: Effects of dietary restriction and exercise

Cited by 19 publications

References 25 publications

Effects of dietary fat type and energy restriction on adipose tissue fatty acid composition and leptin production in rats

Effects of dietary fat type and energy restriction on adipose tissue fatty acid composition and leptin production in rats

Effect of exercise training on the fatty acid composition of lipid classes in rat liver, skeletal muscle, and adipose tissue

Adiponectin is associated with serum and adipose tissue fatty acid composition in rats

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