Fatigue favors in vitro Th1 and Th17-like cell expansion and reduces corticoid sensitivity in MS patients

Alvarenga-Filho, Hélcio; Salles, Marisa; Hygino, Joana; Ferreira, Thaís B.; Sacramento, Priscila M.; Monteiro, Clarice; Vasconcelos, Cláudia Cristina Ferreira; Alvarenga, Regina Maria Papais; Bento, Cleonice A.M.

doi:10.1016/j.jneuroim.2016.12.013

Cited by 19 publications

(22 citation statements)

References 37 publications

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“…An initial study by a Brazilian team revealed a possible link of fatigue with IL-22 (ref. 38 ). An in vitro study revealed higher potential for IL-22 production by lymphocytes from MS patients with significant fatigue compared to those without fatigue.…”

Section: Il-22mentioning

confidence: 99%

The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR

et al. 2019

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The aim of this paper was to summarise knowledge of IL-22 involvement in multiple sclerosis (MS) and the possible link between IL-22 and two transcription factors-AHR and c-Maf. The conclusion is that despite numerous studies, the exact role of IL-22 in the pathogenesis of MS is still unknown. The expression and function of c-Maf in MS have not been studied. It seems that the functions of c-Maf and AHR are at least partly connected with IL-22, as both directly or indirectly influence the regulation of IL-22 expression. This possible connection has never been studied in MS.

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Section: Il-22mentioning

confidence: 99%

The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR

et al. 2019

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“…MRI and EDSS assessments do not well reflect fatigue experience in MS patients [84]. Possible links between inflammation and fatigue in MS have been suggested [86] but although IL-6 [87][88][89] has been implicated, its association with fatigue is not firmly established and published data on NFL, CXCL1, CXCL10 and CXCL13 levels in CSF in relation to fatigue scores are lacking. Treatment of fatigue mainly involves non-pharmacological interventions, e.g.…”

Section: Fatigue In Multiple Sclerosismentioning

confidence: 99%

Biomarkers and Disease Activity in Multiple Sclerosis : A cohort study on patients with clinically isolated syndrome and relapsing remitting multiple sclerosis

Håkansson

2019

Linköping University Medical Dissertations

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“…Another important factor in the context of MS is IL17 which appears to be implicated in glutamate-mediated excitotoxicity and thus may explain the potential link between inflammation and neurodegeneration in MS. 52 The relationship between fatigue and IL17 levels has been addressed by three works that yielded inconsistent outcomes, with two studies confirming such a correlation 47 , 53 and one denying it. 56 …”

Section: Peripheral Inflammation and Ms Fatiguementioning

confidence: 99%

Is there a link between inflammation and fatigue in multiple sclerosis?

Chalah¹,

Ayache²

2018

JIR

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PurposeAmong autoimmune diseases of the central nervous system stands multiple sclerosis (MS), which is characterized by demyelination, synaptopathy, and neurodegeneration. MS fatigue can affect up to 90% of patients and be very disabling, with a drastic impact on their quality of life. To date, the evaluation of MS fatigue has relied mainly on subjective scales, and actual therapeutic interventions are challenged by modest efficacy and numerous undesirable effects. Therefore, finding biomarkers of MS fatigue might help in optimizing evaluation and treatment strategies. The main objective here was to assess the relationship between MS fatigue and inflammatory or other immunomediated markers.MethodsResearch was conducted according to PRISMA guidelines. Computerized databases (ie, PubMed/Medline and Scopus) were consulted till February 2018 aiming to identify articles that addressed inflammation and MS fatigue. Studies in English and French published at any time were considered.ResultsA total of 27 studies matched the research criteria. Inconsistency existed regarding the relationship between fatigue and the orexin A system, hypothalamus–pituitary–adrenal axis, and cerebrospinal fluid inflammatory markers. As for peripheral markers, although there was scarcity in the available data, serum proinflammatory cytokines (ie, IL6, TNFα, and IFNγ) seem to be associated with MS fatigue. Finally, no link was found between MS fatigue and T-cell populations (ie, CD3+CD4+ T lymphocytes, regulatory T cells) or other peripheral markers of inflammation (ie, CRP, erythrocyte-sedimentation rate, soluble ICAM1).ConclusionFuture large-scale studies would benefit from comparing the relationship between fatigue and immune measures in patients with different disease phenotypes with and without disease-modifying drugs. With the subjective nature of fatigue scales, finding objective biomarkers for fatigue would be of great help.

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Fatigue favors in vitro Th1 and Th17-like cell expansion and reduces corticoid sensitivity in MS patients

Cited by 19 publications

References 37 publications

The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR

The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR

Biomarkers and Disease Activity in Multiple Sclerosis : A cohort study on patients with clinically isolated syndrome and relapsing remitting multiple sclerosis

Is there a link between inflammation and fatigue in multiple sclerosis?

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