The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR

Zarobkiewicz, Michał K.; Kowalska, Wioleta; Sławiński, M; Roliński, Jacek

doi:10.5507/bp.2019.024

Cited by 6 publications

(3 citation statements)

References 84 publications

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“…The role of IL-22, a proinflammatory member of the IL-10 cytokine family, in the pathogenesis of multiple sclerosis remains to date ambiguous [ 115 ]. It can act as a pathological agent in several autoimmunological diseases and exert a tumor-promoting effect in numerous cancer types, i.e., breast, colon and lung cancers [ 116 ]. It is highly expressed by Th17 cells; however, IL-22 can additionally be secreted by Th22, a fairly newly discovered T lymphocyte CD4+ subset which resides in tissues [ 117 ].…”

Section: Resultsmentioning

confidence: 99%

The Role of Selected Interleukins in the Development and Progression of Multiple Sclerosis—A Systematic Review

Grunwald,

Krętowska-Grunwald,

Adamska-Patruno

et al. 2024

IJMS

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Multiple sclerosis is a disabling inflammatory disorder of the central nervous system characterized by demyelination and neurodegeneration. Given that multiple sclerosis remains an incurable disease, the management of MS predominantly focuses on reducing relapses and decelerating the progression of both physical and cognitive decline. The continuous autoimmune process modulated by cytokines seems to be a vital contributing factor to the development and relapse of multiple sclerosis. This review sought to summarize the role of selected interleukins in the pathogenesis and advancement of MS. Patients with MS in the active disease phase seem to exhibit an increased serum level of IL-2, IL-4, IL-6, IL-13, IL-17, IL-21, IL-22 and IL-33 compared to healthy controls and patients in remission, while IL-10 appears to have a beneficial impact in preventing the progression of the disease. Despite being usually associated with proinflammatory activity, several studies have additionally recognized a neuroprotective role of IL-13, IL-22 and IL-33. Moreover, selected gene polymorphisms of IL-2R, IL-4, IL-6, IL-13 and IL-22 were identified as a possible risk factor related to MS development. Treatment strategies of multiple sclerosis that either target or utilize these cytokines seem rather promising, but more comprehensive research is necessary to gain a clearer understanding of how these cytokines precisely affect MS development and progression.

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Section: Resultsmentioning

confidence: 99%

The Role of Selected Interleukins in the Development and Progression of Multiple Sclerosis—A Systematic Review

Grunwald,

Krętowska-Grunwald,

Adamska-Patruno

et al. 2024

IJMS

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“…Apart from IL-17, Th17-like cells may also produce IL-22 (Zarobkiewicz et al 2019c), a cytokine acting mostly on non-hematological cells, e.g., epithelial cells (Rutz et al 2013). Under the majority of experimental settings, IL-22 was found to be protective in murine model of asthma; though in fungal asthma, it was found to be rather pathogenic (Hirose et al 2018).…”

Section: Th17-like γδ T May Reduce Ahr In Murine Model Of Asthmamentioning

confidence: 99%

γδ T Lymphocytes in Asthma: a Complicated Picture

Zarobkiewicz

Wawryk‐Gawda

Kowalska

et al. 2021

Arch. Immunol. Ther. Exp.

Self Cite

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A minor subset (approximately 5%) of peripheral T cells has their TCR build up from γ and δ chains instead of α and β—those are the γδ T lymphocytes. They can be functionally divided into subsets, e.g., Th1-, Th2-, Th9-, Th17-, Tfh-, and Treg-like γδ T cells. They share some specifics of both innate and adaptive immunity, and are capable of rapid response to a range of stimuli, including some viral and bacterial infections. Atopic diseases, including asthma, are one of major health-related problems of modern western societies. Asthma is one of the most common airway diseases, affecting people of all ages and having potential life-threatening consequences. In this paper, we review the current knowledge about the involvement of γδ T cells in the pathogenesis of asthma and its exacerbations. We summarize both the studies performed on human subjects as well as on the murine model of asthma. γδ T cells seem to be involved in the pathogenesis of asthma, different subsets probably perform opposite functions, e.g., symptom-exacerbating Vγ1 and symptom-suppressing Vγ4 in mice model of asthma.

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“…Erk (extracellular-signal regulated kinase) participates in immunomodulation and has been proposed as a possible therapeutic target [119]. AHR (aryl hydrocarbon receptor) has recently been associated with interleukin-22, whose exact role in the pathogenesis of MS is still unknown [120]. Sod (superoxide dismutase) is a detoxicant enzyme that becomes important in the case of dysfunctional and impaired ROS metabolism occurring in neurodegenerative disorders such as MS [121].…”

Section: Figurementioning

confidence: 99%

Contribution of Metabolomics to Multiple Sclerosis Diagnosis, Prognosis and Treatment

Rispoli

Valentinuzzi

Luca

et al. 2021

IJMS

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Metabolomics-based technologies map in vivo biochemical changes that may be used as early indicators of pathological abnormalities prior to the development of clinical symptoms in neurological conditions. Metabolomics may also reveal biochemical pathways implicated in tissue dysfunction and damage and thus assist in the development of novel targeted therapeutics for neuroinflammation and neurodegeneration. Metabolomics holds promise as a non-invasive, high-throughput and cost-effective tool for early diagnosis, follow-up and monitoring of treatment response in multiple sclerosis (MS), in combination with clinical and imaging measures. In this review, we offer evidence in support of the potential of metabolomics as a biomarker and drug discovery tool in MS. We also use pathway analysis of metabolites that are described as potential biomarkers in the literature of MS biofluids to identify the most promising molecules and upstream regulators, and show novel, still unexplored metabolic pathways, whose investigation may open novel avenues of research.

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The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR

Cited by 6 publications

References 84 publications

The Role of Selected Interleukins in the Development and Progression of Multiple Sclerosis—A Systematic Review

The Role of Selected Interleukins in the Development and Progression of Multiple Sclerosis—A Systematic Review

γδ T Lymphocytes in Asthma: a Complicated Picture

Contribution of Metabolomics to Multiple Sclerosis Diagnosis, Prognosis and Treatment

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