Fatal Septicemia Due to Mycoplasma arginini: A New Human Zoonosis

Yechouron, Ariane; Lefebvre, Johanne; Robson, Hugh G.; Rose, David L.; Tully, Joseph G.

doi:10.1093/clind/15.3.434

Cited by 44 publications

(23 citation statements)

References 38 publications

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“…Reports of resistance of cell wall bacteria and Mycoplasma to conventional treatments have also increased (Yechouron et al, 1992;Ma et al, 2017) and studies are in progress to determine other active principles present in the most promising species such as E. brevistyla and E. handroana.…”

Section: Resultsmentioning

confidence: 99%

Chemical composition, antibacterial and antimycoplasma activities of four Eugenia species growing in Brazil

Tenfen¹,

Boeder²,

Bella-Cruz³

et al. 2017

J. Med. Plants Res.

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The aim of this study was to evaluate the chemical composition and antimicrobial activity of four unexplored Eugenia species: Eugenia brevistyla, Eugenia handroana, Eugenia catharinae and Eugenia stigmatosa. Eight extracts and eighteen fractions were screened for their antibacterial activity against some selected bacteria including Mycoplasma. Phytochemical screening revealed that the plants were rich in terpenes and phenolic compounds. Antimicrobial evaluation revealed that E. handroana (FAEF-EH) and E. brevistyla (FAEF-EB) had the highest activity against Staphylococcus aureus with minimum inhibitory concentration (MIC) of 15.62 µg/ml Mycoplasma while FAEF-EH also presented the best activity with MIC of 62.5 µg/ml against Mycoplasma pneumonia M129. Some isolated compounds, betulinic acid and glutinol, also exhibited antibacterial property against some bacteria used in the study. All the four species studied presented promising antibacterial activity while the active principles are yet to be elucidated.

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Section: Resultsmentioning

confidence: 99%

Chemical composition, antibacterial and antimycoplasma activities of four Eugenia species growing in Brazil

Tenfen¹,

Boeder²,

Bella-Cruz³

et al. 2017

J. Med. Plants Res.

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“…Based on the facts that (1) immunodeficiencies are frequently associated with mycoplasma infections [35,36], (2) mycoplasmas are known to exert profound effects on the cells of the immune system [for review, see ref. 37], and (3) the suppressive effect of activated macrophages on the proliferative responses of lymphocytes to mitogens or antigens is partially attributed to NO [38], it is possible that some of the features presented by immunodeficient patients may be ascribed to NO production induced by mycoplasma infections.…”

Section: Discussionmentioning

confidence: 99%

Mycoplasma arginini enhances cytotoxicity of thioglycollate-elicited murine macrophages toward YAC-1 tumor cells through production of NO

Ribeiro‐Dias

Russo

Barbuto

et al. 1999

Journal of Leukocyte Biology

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Bacterial products stimulate macrophage tumoricidal activity through release of tumor necrosis factor (TNF) and nitric oxide (NO). We show here that thioglycollate-elicited macrophages acquire cytotoxic activity when cocultured with Mycoplasma arginini-infected YAC-1 tumor cells and release TNF and NO. Fixed mycoplasmainfected cells, supernatants from infected-cell cultures, or purified heat-killed mycoplasma obtained from cell-free cultures were all able to induce TNF and NO production. Thus, the mycoplasma per se and not a product of infected cells induce the release of these molecules. Addition of prostaglandin E 2 (PGE 2 ) to the cocultures, which reduced TNF release, or antibodies to TNF, did not affect macrophage cytotoxicity nor NO release. Inhibition of NO production by L-NAME or aminoguanidine reduced the cytotoxicity, and treatment with a NO donor was toxic to YAC-1 cells. These results indicate that M. arginini activates thioglycollateelicited murine macrophages for NO and TNF release increasing their cytotoxic activity toward YAC-1 cells and that this activity is dependent on NO but not TNF release. J. Leukoc. Biol. 65: 808-814; 1999.

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“…The first human case was a fatal M. arginini septicemia with pneumonia reported in a 64-year-old slaughterhouse worker with advanced non-Hodgkin's lymphoma (39). Our EF patient may represent a case of induced autoimmunity, where the consumption of LT and anabolic steroids from uncontrolled sources could contribute to disease development.…”

mentioning

confidence: 85%

“…Thus, in addition to M. arginini, rare human infections with Mycoplasma bovis (23), Mycoplasma phocicerebrale (4), and presumably animal hemotrophic mycoplasma species (14,29,32,33) have been reported. In some cases, the "jump" of animal mycoplasma to humans may have a pathological impact, particularly under predisposing conditions such as immunodeficiency (25,39). Mycoplasma infections have been associated with autoimmune disorders (15,37), but their role in disease pathogenesis is unclear.…”

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confidence: 99%

Eosinophilic Fasciitis Associated with Mycoplasma arginini Infection

et al. 2012

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Eosinophilic fasciitis (EF) with generalized sclerodermiform skin lesions developed over a 19-month period in a previously healthy 23-year-old man. Although we confirmed EF by skin histology and laboratory tests, the recurrent fevers and the clinical observation of sclerotic prepuce with urethritis indicated further bacteriological analysis by conventional microbiological and DNA-based tests. Urethra cultures were positive for an arginine-hydrolyzing mycoplasma and Ureaplasma urealyticum. The patient also had serum IgM antibodies to Mycoplasma pneumoniae using enzyme-linked immunosorbent assay (ELISA)-based qualitative detection. Mycoplasma arginini was isolated from two independent venous blood serum samples and was identified by conventional microbiological tests and sequencing of the 16S rRNA and rpoB genes (GenBank sequence accession numbers HM179555 and HM179556, respectively). M. arginini genomic DNA also was detected by species-specific PCR in the skin lesion biopsy sample. Treatment with corticosteroids and long-term courses of selected antibiotics led to remission of skin symptoms and normalization of laboratory values. This report provides the first evidence of EF associated with mycoplasma infection and the second report of human infection with M. arginini and therefore suggests that this mycoplasma infection might have contributed to the pathogenesis of the disease. CASE REPORTA 23-year-old male, a former bodybuilder, sought medical treatment for progressive generalized skin tightening. His previous medical history was unremarkable. The patient had terminated sport exercises 19 months earlier due to a sudden, progressive skin induration, which led to restricted movement of wrists and ankles within several months, and cutaneous symptoms gradually extended to the extremities and to the upper body. At the beginning of his illness, he quit body building and stopped anabolic steroid consumption. Within 1 year, he lost 23 kg, he became febrile in the afternoons, and his skin disease slowly progressed. Serological tests for HIV, hepatitis C virus (HCV), and Lyme borreliosis were negative. His crista biopsy specimen revealed eosinophilia. The patient was treated with a very low dose of prednisone (10 mg/day orally [p.o.]) for the next 6 months without dermatological improvement. Any attempt to decrease the prednisone dosage resulted in return of arthralgia and fever.Upon initial examination, the patient suffered from generalized skin tightening and tautness on his whole trunk and on all the extremities except the fingers and toes. He also exhibited multiple cutaneous venous furrowing on the arms (Fig. 1). The shiny, brownish, firm skin with some porcelain-whitish patches was tightly bound to the underlying tissues, resulting in a restricted movement of the chest, wrists, elbows, ankles, and knees. The genital region was also involved; the indurated, sclerotic, depigmented prepuce led to phimosis and showed lichen sclerosus-like symptoms with an inflamed urethral orifice.Initial laboratory tests showed periph...

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Fatal Septicemia Due to Mycoplasma arginini: A New Human Zoonosis

Cited by 44 publications

References 38 publications

Chemical composition, antibacterial and antimycoplasma activities of four Eugenia species growing in Brazil

Chemical composition, antibacterial and antimycoplasma activities of four Eugenia species growing in Brazil

Mycoplasma arginini enhances cytotoxicity of thioglycollate-elicited murine macrophages toward YAC-1 tumor cells through production of NO

Eosinophilic Fasciitis Associated with Mycoplasma arginini Infection

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