Fatal Neisseria macacae infective endocarditis: first report

Abstract

We present here the first case of N. macacae infective endocarditis in a 65-year-old man with a native aortic valve infection complicated by a peri-aortic abscess. N. macacae was isolated from blood culture and was found on the cardiac valve using 16S rDNA detection. Despite an appropriate antibiotic therapy, and aortic homograft replacement, and mitral repair, the patient died 4 days after surgery from a massive hemorrhagic stroke.

Precise diagnosis of Neisseria macacae infective endocarditis assisted by nanopore sequencing

“…The first case of N. macacae infective endocarditis in humans was reported in 2017 [1]. Unfortunately, that patient died 4 days after surgery in France [1]. Now, we present in this study a survival case of N. macacae infective endocarditis.…”

“…Infective endocarditis (IE) caused by Neisseria macacae (N. macacae) in humans is extremely rare. The first case of N. macacae infective endocarditis in humans was reported in 2017 [1]. Unfortunately, that patient died 4 days after surgery in France [1].…”

Bacterial isolation of oral, rectum and anus swabs from Macaca fascicularis and Macaca namestrina in Kemasul, Pahang, Malaysia

“…Disease transmission between humans and monkeys were rarely reported. However, recently, Vecten et al (2017) reported that a 65-year-old patient was infected with N. macacae endocarditis with complicated aortic valve and peri-aortic abscess. Salmonella sp.…”

Refractory Peritoneal Dialysis Peritonitis Due to <i>Neisseria macacae</i>: A Case Report and Review of the Literature

“…The second case was infectious endocarditis in a 65-year-old man. Antibiotics with ceftriaxone and gentamicin were not effective, and the patient ultimately died ( 5 ). In our case, N. macacae was identified from a peritoneal fluid culture, and the route of infection was suspected to be wet contamination.…”

“…We changed piperacillin/tazobactam to ceftriaxone during the course based on the MIC and the widely accepted recognition that ceftriaxone is effective against Neisseria species. In addition, a previous case report of N. macacae and three of the four cases of N. mucosa peritonitis were treated with ceftriaxone, and most showed a good clinical course ( 4 , 5 , 8 - 11 ).…”