Refractory Peritoneal Dialysis Peritonitis Due to &lt;i&gt;Neisseria macacae&lt;/i&gt;: A Case Report and Review of the Literature

Iyama, Takuji; Hamada, Shintaro; Takata, Tomoaki; Hoi, Shotaro; Fukuda, Satoshi; Isomoto, Hajime

doi:10.2169/internalmedicine.4832-20

Cited by 6 publications

(7 citation statements)

References 14 publications

(16 reference statements)

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“…Ceftriaxone – along with gentamycin – was also found to be successful in treating N. elongata peritonitis 8 . Intraperitoneal ceftazidime (2–3 weeks) was a successful agent in our patient’s treatment and another reported case of Neisseria subflava biovar perflava peritonitis 11 , both of which had a penicillin-resistant organism.…”

Section: Discussionmentioning

confidence: 57%

“…Multiple case reports showed the implication of traditionally known nonpathogenic/benign (nongonococcal and nonmeningococcal) Neisseria species 5 in serious medical conditions, for example, N. elongata and Neisseria mucosa endocarditis 6 , 7 . Peritonitis was also reported in such species, including N. elongata 8 , N. mucosa 5 , Neisseria cinerea 5 , 9 , Neisseria macacae 10 , and Neisseria subflava biovar perflava 11 .…”

Section: Discussionmentioning

confidence: 92%

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Neisseria elongata–mediated peritonitis in an end-stage renal disease patient on automated peritoneal dialysis: a case report and literature review

Alsayed¹,

Abdalla²,

Ali³

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction: Peritoneal dialysis (PD) can result in peritonitis, which frequently causes severe and near-fatal clinical implications if left untreated. Usually, gram-positive bacteria are the most common organisms involved. Uncommonly recognized as the cause of peritonitis in PD patients, Neisseria elongata is a gram-negative nasal and oropharyngeal normal flora organism. Case presentation: We report a rare case of a 29-year-old man who had received automated PD for 6 years and had N. elongata peritonitis. Discussion: Several case reports of Neisseria-related peritonitis may point to the potential pathogenicity of such organisms and suggest that many cases of culture-negative peritonitis may have been misdiagnosed. Poor nutrition and chronic kidney disease have been suggested as potential risk factors for N. elongata peritonitis, both of which are present in our patient. With appropriate antibiotic use, most of the cases respond well to empirical treatment. Conclusion: Although rare, N. elongata can lead to PD catheter. peritonitis that, in some cases, require changing to hemodialysis.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 92%

Neisseria elongata–mediated peritonitis in an end-stage renal disease patient on automated peritoneal dialysis: a case report and literature review

Alsayed¹,

Abdalla²,

Ali³

et al. 2023

Annals of Medicine &Amp; Surgery

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show abstract

“…Ceftriaxone -along with gentamycin-was also found to be successful in treating Neisseria elongata peritonitis [ 8 ]. Intraperitoneal ceftazidime (2–3 weeks) was a successful agent in our patient's treatment and another reported case of Neisseria subflava biovar perflava peritonitis [ 12 ], both of which had a penicillin-resistant organism.…”

Section: Discussionmentioning

confidence: 78%

“…Multiple case reports showed the implication of traditionally known nonpathogenic/benign (nongonococcal and nonmeningococcal) Neisseria species [ 5 ] in serious medical conditions, e.g., Neisseria elongata and Neisseria mucosa endocarditis [ 6 , 7 ]. Peritonitis was also reported in such species, including Neisseria elongata [ 8 ], Neisseria mucosa [ 5 ], Neisseria cinerea [ 9 , 10 ], Neisseria macacae [ 11 ], and Neisseria subflava biovar perflava [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Neisseria elongata -mediated peritonitis in an end-stage renal disease patient on automated peritoneal dialysis, A case report and literature review

Alsayed

Abdalla

Ali

et al. 2022

Annals of Medicine &Amp; Surgery

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“…Only one case of infectious endocarditis in an adult with N. macacae bacteremia was reported [2]. Previously, reports of N. macacae infection in humans include peritonitis in patients on peritoneal dialysis [5]. Addtionally, N. macacae has been isolated from the upper respiratory tract of neutropenic patients [4].…”

Section: Discussionmentioning

confidence: 99%

Neisseria macacae bacteremia: report of two cases with a literature review

et al. 2020

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Background: Neisseria macacae was discovered in the oral cavity of monkeys in 1983. In humans, it has been isolated from the upper respiratory tract of neutropenic patients. However, only two cases of N. macacae bacteremia have been reported in a 65-year-old man with infective endocarditis and a 5-month-old child with fever and petechiae. There are no reports of infections in cancer patients. Here, we present two cases of N. macacae bacteremia in cancer patients. Case presentation: In the first case, a 42-year-old woman who underwent ovarian cancer surgery presented with duodenal invasion associated with multiple lymph node metastasis. N. macacae was isolated from her blood culture and identified using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). In the second case, a 69-year-old woman with a long-standing history of esophagogastric junction cancer presented with fever. She had stage IVB cancer with lung, bone, and multiple lymph node metastasis. The last chemotherapy was administered 5 weeks before N. macacae was detected using MALDI-TOF MS and nitrate test negative. In both cases, transthoracic echography showed no vegetation. Antibiotics were administered for 14 and 13 days in the first and second cases, respectively. In both cases, fever alleviated on day 4 of antibiotic administration. Both patients were discharged after their conditions improved. Conclusions: This, to our knowledge, is the first report of N. macacae bacteremia in cancer patients. Both patients, mucosal damage was observed in the upper gastrointestinal tract. Therefore, exclusion diagnosis suggested that bacteremia invasion was caused by mucosal rupture in both cases. Both cases responded well to treatment with βlactam antibiotics and improved after 2 weeks. Modifying the treatment based on the source of the infection may shorten the treatment period. Therefore, further research on N. macacae bacteremia is necessary. Immunocompromised patients such as those with cancer are susceptible to mucosal damage by unusual bacterial species such as N. macacae despite not having contact with monkeys.

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Refractory Peritoneal Dialysis Peritonitis Due to <i>Neisseria macacae</i>: A Case Report and Review of the Literature

Cited by 6 publications

References 14 publications

Neisseria elongata–mediated peritonitis in an end-stage renal disease patient on automated peritoneal dialysis: a case report and literature review

Neisseria elongata–mediated peritonitis in an end-stage renal disease patient on automated peritoneal dialysis: a case report and literature review

Neisseria elongata -mediated peritonitis in an end-stage renal disease patient on automated peritoneal dialysis, A case report and literature review

Neisseria macacae bacteremia: report of two cases with a literature review

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