Fat graft transfer in children's facial malformations: A prospective three-dimensional evaluation

Guibert, Marc; Franchi, G.; Ansari, Edward; Billotet, Benjamin; Diner, P.A.; Cassier, Sophie; Vazquez, M.-P.; Picard, A.; Kadlub, Natacha

doi:10.1016/j.bjps.2013.02.015

Cited by 48 publications

(24 citation statements)

References 21 publications

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“…[3][4][5]. The mean satisfaction score at immediate postoperative (score = 4.3) was higher than that at post-3 M (score = 4.1) and post-12 M (score = 4.0).…”

Section: Resultscontrasting

confidence: 58%

“…4 Considering the multidimensional atrophy and the variable and unpredictable fat absorption, few scholars have quantitatively evaluated the grafted fat of PHA. 5,6 To our knowledge, facial imaging measurement is a key tool used to diagnose and treat PHA. Although 3-dimensional (3D) digital technology (computed tomography [CT] or 3D laser-scanning camera) is effectively used in imaging hard and/or soft tissues, it cannot quantify the volumetric deficiency of affected soft tissues.…”

mentioning

confidence: 99%

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Autologous Fat Grafting With Combined Three-Dimensional and Mirror-Image Analyses for Progressive Hemifacial Atrophy

Yang

et al. 2016

Annals of Plastic Surgery

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“…[3][4][5]. The mean satisfaction score at immediate postoperative (score = 4.3) was higher than that at post-3 M (score = 4.1) and post-12 M (score = 4.0).…”

Section: Resultscontrasting

confidence: 58%

mentioning

confidence: 99%

Autologous Fat Grafting With Combined Three-Dimensional and Mirror-Image Analyses for Progressive Hemifacial Atrophy

Yang

et al. 2016

Annals of Plastic Surgery

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“…Fat grafts have been used as soft tissue filler to improve function and aesthetic form after trauma, 1 thermal or radiation damage, 2 the correction of congenital anomalies, 3 or aging. 4 In the aesthetic surgery arena, they have been used for body and facial contouring 5,6 and breast augmentation.…”

mentioning

confidence: 99%

Do Stem Cells Have an Effect When We Fat Graft?

Rinker

2016

Annals of Plastic Surgery

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Fat grafting has become a widely accepted modality of soft tissue restoration and has found applications in many areas of aesthetic and reconstructive plastic surgery. Numerous claims have been made regarding the regenerative effects of fat grafting on the recipient bed. The purpose of this paper is to survey the available literature to answer the question of whether fat grafting has a positive effect on the surrounding tissues. It has been convincingly demonstrated that fat grafts contain viable adipose-derived stem cells (ASCs). The fate of these cells is determined by the microenvironment of the recipient bed, but animal studies have shown that a large fraction of ASCs survive engraftment. Numerous clinical studies have demonstrated the positive effects of fat grafting on recipient tissues. Improvement in validated scar scores as well as scar stiffness measurements have been documented after fat grafting of burn scars. Fat grafting has also been convincingly demonstrated to improve the quality of irradiated tissues, as measured by validated clinical scales and staged histology. It is ultimately unclear whether ASCs are responsible for these effects, but the circumstantial evidence is weighty. Fat grafting is effective for volumizing and improving skin quality in the setting of radiation, burns, and other scars. The observed effects are likely due to ASCs, but the evidence does not support the routine use of ASC-enriched fat grafts.

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“…Studies have shown that autologous fat grafting is effective in reconstructive and cosmetic treatments for patients affected by tissue volume loss due to aging, infection (facial lipoatrophy from HIV), trauma, congenital defects, in correcting breast defects following tumorectomy, and in post mastectomy reconstruction [2,3,4,5] or other soft tissue impairments generating asymmetry or deformity [6,7,8,9,10]. …”

Section: Introductionmentioning

confidence: 99%

The Selective Centrifugation Ensures a Better In Vitro Isolation of ASCs and Restores a Soft Tissue Regeneration In Vivo

Francesco

Guastafierro

Nicoletti

et al. 2017

IJMS

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Autologous fat grafting procedures in plastic surgery have been extensively used to reinforce soft tissue in congenital or acquired tissue impairments. With this background, the aim of this study is firstly to examine the impact of a selective centrifugation on existing adipose stem cells (ASCs) in terms of stemness profile maintenance and, secondly, to investigate the effect of restoring volume in reconstruction on patients affected by soft tissue damage. After centrifugation, the fat graft products were separated into two layers and subsequently examined in vitro for the expression of CD34, CD90, CD117, CD105, CD29, CD31, CD44, CD73, CD133, CD14 and CD45 markers by flow cytometry and gene expression analyses were performed for Sox2, WNT3A, END, CD44, FUT4, COLL1, CTNNB1, hbEGF, KRTLG, MMP2 and VIM genes. The results showed that in the middle-high density (MHD) layer there was a peak concentration of ASCs, compared to another layer obtained after centrifugation. Research carried out on patients under treatment for soft tissue regeneration using cells obtained from MHD layer selection will be fundamental in comparative analysis. These studies will lead to an adequate standardization of outcomes, provided that treatment is performed through cell selection. Therefore, a unique procedure in tissue reconstruction and regeneration through fat grafting is presented here.

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Fat graft transfer in children's facial malformations: A prospective three-dimensional evaluation

Cited by 48 publications

References 21 publications

Autologous Fat Grafting With Combined Three-Dimensional and Mirror-Image Analyses for Progressive Hemifacial Atrophy

Autologous Fat Grafting With Combined Three-Dimensional and Mirror-Image Analyses for Progressive Hemifacial Atrophy

Do Stem Cells Have an Effect When We Fat Graft?

The Selective Centrifugation Ensures a Better In Vitro Isolation of ASCs and Restores a Soft Tissue Regeneration In Vivo

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