Do Stem Cells Have an Effect When We Fat Graft?

Rinker, Brian

doi:10.1097/sap.0000000000000658

Cited by 18 publications

(13 citation statements)

References 67 publications

(45 reference statements)

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“…13 Stem cell enrichment, in particular, increases fat graft survival with its angiogenic effects. 14 There are many studies in the literature in the direction that ADSC enrichment increases fat graft viability. [15][16][17] Autologous PRP is a whole blood product obtained by centrifugation from the patient's own blood.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Vasonatrin Peptide on Fat Graft Viability: An Experimental Study

et al. 2021

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Vasonatrin peptide (VNP) is a synthetic peptide that possesses vasodilatory, natriuretic, and anti-inflammatory properties. The authors aimed to analyze the effects of VNP on fat graft survival. Twenty Sprague–Dawley rats are randomly divided into two groups of 10. Fat grafts are harvested from the right inguinal region. After preparation, fat grafts are placed to the interscapular region. The first group of rats were administered VNP after their fat injection, while the second group received tail-vein injections of an equal volume of sterile saline following their fat injection. Experiment and control groups are evaluated according to their level of degeneration of adipocytes, fat necrosis, vacuolization, cyst formation in adipocytes, fibrosis of the fat tissue, capillary density, and CD31 immunohistochemical staining. Degeneration, vacuolization, and cyst formation in adipocytes were lower in the experiment group. Increased capillary density in the experiment group was demonstrated by CD31 antibody staining and by counting capillary density under a microscope. The average percentage of change in weight of the fat grafts in the experiment group was lower than that in the control group. The results indicate that VNP has some beneficial effects on fat graft survival by multiple independent mechanisms that influence both local and systemic homeostasis.

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Section: Discussionmentioning

confidence: 99%

The Effects of Vasonatrin Peptide on Fat Graft Viability: An Experimental Study

et al. 2021

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“…Although cell enhancement can be performed in every fat grafting procedure, the evidence does not support the routine use of ASCs-enriched fat grafts and the author has been able to verify this fact during his last four years of experience. The increase in operative time, expenses, and efficiency must drive its use to selected cases [ 17 ]. In the author's experience, cell-assisted fat grafting can be considered an indication whenever graft/host interface is defective, compromising cell survival, or to enhance their regenerative potential in damaged tissues by fibrosis or adhesions.…”

Section: Discussionmentioning

confidence: 99%

Autologous Fat Grafting in Severe Lower Extremity Asymmetries: Report of Four Cases

Monreal

2015

Cureus

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Background: Lower extremity asymmetries are challenging problems in plastic and aesthetic surgery practice. Regardless of their origin, atrophies and asymmetries can be extremely varied and difficult to solve with simple techniques.Objectives: The author reports his experience in the treatment of four patients suffering from severe lower extremity atrophy and asymmetry of different etiologies with autologous fat grafting.Methods: A total of four cases are presented. Patient selection was based on the severity of atrophy and asymmetry. Two patients were treated with two sessions of simple fat grafting and two patients with one session of cell-enriched fat grafting. The end point in each session was determined by tension/blanching of soft tissues. All patients were followed up for at least 12 months after the last session. During the postoperative follow-up, variables, such as objective volume improvement, objective girth loss, return to daily activities, and patient satisfaction, were analyzed.Results: The initial analysis of postoperative results showed a good patient satisfaction rate with no relevant complications and an early return to daily activities. Estimated mean volume improvement for simple fat grafting cases was estimated as 44% after two treatments. Mean volume improvement in cell-enriched fat grafting cases was estimated as 25% after only one treatment.Conclusions: Autologous fat grafting is a safe, effective, and reliable technique to perform aesthetic and reconstructive reshaping of a lower extremity in cases of atrophy or severe asymmetry. Depending on the preoperative soft tissue compliance, cell-assisted fat grafting will play an important role in reducing the number of sessions to perform.

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“…Video-otoscopy analysis was performed using the Paint.net image analysis program (version 4.2.9; dotPDN LLC) to measure the size of the perforations as previously described. 13 For statistical analysis, IBM SPSS Statistics (version 23.0, IBM Corp) was used.…”

Section: Methodsmentioning

confidence: 99%

Long-Term Follow-Up After Fat Graft Myringoplasty: Do Size and Location Matter?

et al. 2020

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Objective: To assess clinical and functional outcomes of a fat graft myringoplasty under local in an office setting. Study Design: Prospective case series. Setting: Tertiary care facility. Patients: Patients with a tympanic membrane (TM) perforation presenting between December 2005 and June 2019. Inclusion criteria included perforation size >25% of the surface of the pars tensa of the TM, entire perforation margins visualized through a transcanal view, and lack of spontaneous closure at the 6-month follow-up. The exclusion criteria were the presence of cholesteatoma, wet appearance of the mucosa in the tympanic cavity, ear discharge in the 3 months before surgery, or signs of ossicular inconsistency. Intervention: In-office fat graft myringoplasty technique under local anesthesia. Main outcome Measures: Complete perforation closure rate and audiometric outcomes. Results: A total of 121 patients underwent the procedure, of whom 21 had bilateral sequential procedures (total 142 ears). Average age was 51.1 ± 18.4 years (range, 3-78 years). The size of perforation was <25% of TM in 39 (27.5%) ears, 25% to 50% of TM in 49 (34.55%) ears, 50% to 75% of TM in 34 (23.91%) ears, and 75% to 100% of TM in 20 (14.10%) ears. Complete perforation closure was evident in 130 (91.55%) of the 142 ears. Preoperative mean air conduction threshold was 59.3 dB (17-95 dB) and significantly improved into 35.6 dB (10-85 dB; P < .0004) after surgery. Preoperative air–bone gap was 30.2 dB (5-70 dB) and also significantly improved into 10.2 dB (5-65 dB; P < .0001) after surgery. Conclusion: In office fat graft myringoplasty, in adult and pediatric patients with variable perforation sizes, is a well-tolerated procedure with very satisfactory clinical results.

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Do Stem Cells Have an Effect When We Fat Graft?

Cited by 18 publications

References 67 publications

The Effects of Vasonatrin Peptide on Fat Graft Viability: An Experimental Study

The Effects of Vasonatrin Peptide on Fat Graft Viability: An Experimental Study

Autologous Fat Grafting in Severe Lower Extremity Asymmetries: Report of Four Cases

Long-Term Follow-Up After Fat Graft Myringoplasty: Do Size and Location Matter?

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