Fasting serum copeptin and asymptomatic peripheral artery disease: No association in patients with type 1 diabetes mellitus

Nattero‐Chávez, Lía; Martínez‐García, M. Ángeles; Fernández‐Durán, Elena; López, Sandra; Avendaño, Beatriz Dorado; Escobar-Morreale, Héctor F.; Luque‐Ramírez, Manuel

doi:10.1016/j.diabet.2020.10.005

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Introducing copeptin in daily clinical practice gave the evidence which copeptin could act as a promising serum biomarker for diagnosing AVP-dependent fluid homeostasis disorders, such as hyponatremia and diabetes insipidus. Despite the fact that copeptin serum concentrations are quite variable and more related to osmolality, copeptin demonstrated significantly higher concentrations in different cases including myocardial infarction (MI), diabetes mellitus, kidney diseases, and critical conditions, which in turn increases the probability of depending on copeptin as an effective prognostic biomarker of diverse diseases [19]. The functions of copeptin as a biomarker in daily clinical practice is being highlighted through the following pages according to results obtained from recent studies.…”

Section: Basic Characteristics Of Copeptinmentioning

confidence: 99%

RETRACTED ARTICLE: Review novel insights into the diagnostic and prognostic function of copeptin in daily clinical practice

Wang

et al. 2023

Mol Biol Rep

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As is shown in previous reports, arginine vasopressin (AVP), as one of the most important hormones within circulation in human beings, is of great clinically significance given that it could maintain the body fluid balance and vascular tone. However, the laboratory measurements AVP in daily clinical practice are shown to be difficult and with low accuracy. Concerning on this notion, it is unpractical to use the serum levels of AVP in diagnosing multiple diseases. On the other hand, another key serum biomarker, copeptin, is confirmed as the C-terminal of the AVP precursor which could be released in equal amounts with AVP, resultantly making it as a sensitive marker of arginine vasopressin release. Notably, emerging recent evidence has demonstrated the critical function of copeptin as a clinical indicator, especially in the diagnosis and prognosis of several diseases in diverse organs, such as cardiovascular disease, kidney disease, and pulmonary disease. In addition, copeptin was recently verified to play an important role in diagnosing multiple acute diseases when combined it with other gold standard serum biomarkers, indicating that copeptin could be recognized as a vital disease marker. Herein, in the current review, the functions of copeptin as a new predictive diagnostic and prognostic biomarker of various diseases, according to the most recent studies, are well summarized. Furthermore, the importance of using copeptin as a serum biomarker in diverse medical departments and the impact of this on improving healthcare service is also summarized in the current review.

show abstract

Section: Basic Characteristics Of Copeptinmentioning

confidence: 99%

RETRACTED ARTICLE: Review novel insights into the diagnostic and prognostic function of copeptin in daily clinical practice

Wang

et al. 2023

Mol Biol Rep

View full text Add to dashboard Cite

show abstract

“…Introducing copeptin in daily clinical practice gave the evidence which copeptin could act as a promising serum biomarker for diagnosing arginine vasopressin-dependent uid homeostasis disorders, such as hyponatremia and diabetes insipidus. Despite the fact that copeptin serum concentrations are quite variable and more related to osmolality, copeptin demonstrated signi cantly higher concentrations in different cases including myocardial infraction, type 1/2 diabetes mellitus, kidney diseases, acute and chronic heart failure, severe hypertension, stroke, pulmonary diseases, psychological stress, birth stress, sepsis, neurological stress and critical conditions, which in turn increases the probability of depending on copeptin as an effective prognostic biomarker of diverse diseases [19]. The functions of copeptin as a biomarker in daily clinical practice is being highlighted through the following pages according to results obtained from recent studies.…”

Section: Stabilitymentioning

confidence: 99%

Novel insights into the diagnostic and prognostic function of copeptin in cardio-metabolic disorders

Wang

Cheng

et al. 2022

Preprint

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As is shown in previous reports, arginine vasopressin, as one of the most important hormones within circulation in human beings, is of great clinically significance given that it could maintain the body fluid balance and vascular tone. However, the laboratory measurements arginine of vasopressin in daily clinical practice are shown to be difficult and with low accuracy. Concerning on this notion, it is unpractical to use the serum levels of arginine vasopressin in diagnosing multiple diseases. On the other hand, another key serum biomarker, copeptin, is confirmed as the C-terminal of the arginine vasopressin precursor which could be released in equal amounts with arginine vasopressin, resultantly making it as a sensitive marker of arginine vasopressin release. Notably, emerging recent evidence has demonstrated the critical function of copeptin as a clinical indicator, especially in the diagnosis and prognosis of several diseases in diverse organs, such as cardiovascular disease, kidney disease, and pulmonary disease. In addition, copeptin was recently verified to play an important role in diagnosing multiple acute diseases when combined it with other gold standard serum biomarkers, indicating that copeptin could be recognized as a vital disease marker. Herein, in the current review, the functions of copeptin as a new predictive diagnostic and prognostic biomarker of various diseases, according to the most recent studies, are well summarized. Furthermore, the importance of using copeptin as a serum bio-marker in diverse medical departments and the impact of this on improving healthcare service is also summarized in the current review.

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“…It is also a risk predictor for end-stage renal disease, coronary heart disease, and all-cause mortality in people with type 1 diabetes (T1DM) [5]. However, we have recently reported that copeptin does not appear to be a reliable marker for the screening of asymptomatic peripheral arterial disease in a population of patients with T1DM [6]. We here explore the putative relationships between serum copeptin level and carotid intima-media thickness (cIMT) in asymptomatic T1DM-patients comprehensively investigated for subclinical carotid atherosclerosis.…”

mentioning

confidence: 99%

High serum copeptin may be a marker of an increased carotid intima-media thickness in asymptomatic patients with type 1 diabetes.

Nattero‐Chávez

Martínez‐García

Fernández‐Durán

et al. 2021

Preprint

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Copeptin is a stable peptide derived from cleavage of the precursor of arginine-vasopressin (AVP), [1,2] that can be easily measured by using a simple rapid assay. Copeptin has been related with an increased incidence of stroke and cardiovascular mortality in individuals with diabetes, mainly type 2 [3,4]. It is also a risk predictor for end-stage renal disease, coronary heart disease, and all-cause mortality in people with type 1 diabetes (T1DM) [5]. However, we have recently reported that copeptin does not appear to be a reliable marker for the screening of asymptomatic peripheral arterial disease in a population of patients with T1DM [6]. We here explore the putative relationships between serum copeptin level and carotid intima-media thickness (cIMT) in asymptomatic T1DM-patients comprehensively investigated for subclinical carotid atherosclerosis.

show abstract

Fasting serum copeptin and asymptomatic peripheral artery disease: No association in patients with type 1 diabetes mellitus

Cited by 4 publications

References 15 publications

RETRACTED ARTICLE: Review novel insights into the diagnostic and prognostic function of copeptin in daily clinical practice

RETRACTED ARTICLE: Review novel insights into the diagnostic and prognostic function of copeptin in daily clinical practice

Novel insights into the diagnostic and prognostic function of copeptin in cardio-metabolic disorders

High serum copeptin may be a marker of an increased carotid intima-media thickness in asymptomatic patients with type 1 diabetes.

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