RETRACTED ARTICLE: Review novel insights into the diagnostic and prognostic function of copeptin in daily clinical practice

Abstract

As is shown in previous reports, arginine vasopressin (AVP), as one of the most important hormones within circulation in human beings, is of great clinically significance given that it could maintain the body fluid balance and vascular tone. However, the laboratory measurements AVP in daily clinical practice are shown to be difficult and with low accuracy. Concerning on this notion, it is unpractical to use the serum levels of AVP in diagnosing multiple diseases. On the other hand, another key serum biomarker, copeptin, is confirmed as the C-terminal of the AVP precursor which could be released in equal amounts with AVP, resultantly making it as a sensitive marker of arginine vasopressin release. Notably, emerging recent evidence has demonstrated the critical function of copeptin as a clinical indicator, especially in the diagnosis and prognosis of several diseases in diverse organs, such as cardiovascular disease, kidney disease, and pulmonary disease. In addition, copeptin was recently verified to play an important role in diagnosing multiple acute diseases when combined it with other gold standard serum biomarkers, indicating that copeptin could be recognized as a vital disease marker. Herein, in the current review, the functions of copeptin as a new predictive diagnostic and prognostic biomarker of various diseases, according to the most recent studies, are well summarized. Furthermore, the importance of using copeptin as a serum biomarker in diverse medical departments and the impact of this on improving healthcare service is also summarized in the current review.

The Relationship Between Copeptin Level and Enuresis in Children Aged 5 - 15 Years

“…Copeptin is synthesized with AVP and is a stable fragment of AVP precursor, and its amount is equivalent to AVP in the bloodstream of healthy and diseased people, and there is a high correlation between them. This biomarker could be applied to body fluid homeostasis disorders that depend on vasopressin (13)(14)(15)(16)(17)(18). In contrast to AVP, copeptin measurement needs a small sample, and the technical procedure is easier; it is very stable with less than 20% loss of recovery at room temperature for 7 days and at 4 degrees centigrade for 14 days (15).…”