Fast quantification of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid (THCA) using microwave-accelerated derivatisation and gas chromatography–triple quadrupole mass spectrometry

Brabanter, Nik De; Gansbeke, Wim Van; Hooghe, Fiona; Eenoo, Peter Van

doi:10.1016/j.forsciint.2012.11.004

Cited by 22 publications

(14 citation statements)

References 34 publications

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“…44 The study demonstrated that, like other cannabinoids, CBG (5) also enters the body during smoking cannabis and is excreted in the urine in its conjugated glucuronide form. De Brabanter et al 45 published a rapid and sensitive GC-based method for the determination of THCA (11)…”

Section: Urine Samplesmentioning

confidence: 99%

Gas chromatographic analysis of naturally occurring cannabinoids: A review of literature published during the past decade

Nahar

Chen

Sarker

2019

Phytochemical Analysis

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Introduction Cannabinoids are organic compounds, natural or synthetic, that bind to the cannabinoid receptors and have similar pharmacological properties as produced by the cannabis plant, Cannabis sativa. Gas chromatography (GC), e.g. gas chromatography mass spectrometry (GC–MS), is a popular analytical tool that has been used extensively to analyse cannabinoids in various matrices. Objective To review published literature on the use of various GC‐based analytical methods for the analysis of naturally occurring cannabinoids published during the past decade. Methodology A comprehensive literature search was performed utilising several databases, like Web of Knowledge, PubMed and Google Scholar, and other relevant published materials including published books. The keywords used, in various combinations, with cannabinoids being present in all combinations, in the search were cannabinoids, Cannabis sativa, marijuana, analysis, GC, quantitative, qualitative and quality control. Results During the past decade, several GC‐based methods for the analysis of cannabinoids have been reported. While simple one‐dimensional (1D) GC–MS and GC‐FID (flame ionisation detector) methods were found to be quite common in cannabinoids analysis, two‐dimensional (2D) GC–MS as well as GC–MS/MS also were popular because of their ability to provide more useful data for identification and quantification of cannabinoids in various matrices. Some degree of automation in sample preparation, and applications of mathematical and computational models for optimisation of different protocols were observed, and pre‐analyses included various derivatisation techniques, and environmentally friendly extraction protocols. Conclusions GC‐based analysis of naturally occurring cannabinoids, especially using GC–MS, has dominated the cannabinoids analysis in the last decade; new derivatisation methods, new ionisation methods, and mathematical models for method optimisation have been introduced.

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Section: Urine Samplesmentioning

confidence: 99%

Gas chromatographic analysis of naturally occurring cannabinoids: A review of literature published during the past decade

Nahar

Chen

Sarker

2019

Phytochemical Analysis

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“…[140][141][142] Since the raise of the urinary threshold for THCCOOH came unexpected, studies from early 2013 concerning improved/accelerated quantification approaches have become obsolete, even though the principle is certainly still valid. [143] Controlled by a deuterated internal standard, a robust quantitative approach covering the range of 1-100 ng/mL was presented, and the completion of a set of samples required less than 30 min. [143] Controlled by a deuterated internal standard, a robust quantitative approach covering the range of 1-100 ng/mL was presented, and the completion of a set of samples required less than 30 min.…”

Section: Cannabinoids and Glucocorticosteroids Cannabinoidsmentioning

confidence: 99%

“…De Brabanter et al suggested the basic hydrolysis of 1 mL of urine (7 min at 56°C) followed by LLE, evaporation, and microwaveassisted trimethylsilylation (1.5 min) followed by fast GC-MS/MS analysis (4 min). [143] Controlled by a deuterated internal standard, a robust quantitative approach covering the range of 1-100 ng/mL was presented, and the completion of a set of samples required less than 30 min.…”

Section: Cannabinoids and Glucocorticosteroids Cannabinoidsmentioning

confidence: 99%

Annual banned‐substance review: analytical approaches in human sports drug testing

Thevis

Kuuranne

Geyer

et al. 2013

Drug Testing and Analysis

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Monitoring the misuse of drugs and the abuse of substances and methods potentially or evidently improving athletic performance by analytical chemistry strategies is one of the main pillars of modern anti-doping efforts. Owing to the continuously growing knowledge in medicine, pharmacology, and (bio)chemistry, new chemical entities are frequently established and developed, various of which present a temptation for sportsmen and women due to assumed/attributed beneficial effects of such substances and preparations on, for example, endurance, strength, and regeneration. By means of new technologies, expanded existing test protocols, new insights into metabolism, distribution, and elimination of compounds prohibited by the World Anti-Doping Agency (WADA), analytical assays have been further improved in agreement with the content of the 2013 Prohibited List. In this annual banned-substance review, literature concerning human sports drug testing that was published between October 2012 and September 2013 is summarized and reviewed with particular emphasis on analytical approaches and their contribution to enhanced doping controls.

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“…A análise confirmatória é realizada por uma técnica mais específica, como a cromatografia gasosa acoplada à espectrometria de massas. No processo de confirmação da análise, a primeira fase é a extração do composto de interesse da amostra biológica, para excluir possíveis interferências dos constituintes da matriz (DE BRABANTER et al, 2013;OLIVEIRA, et al, 2008;PANTALEAO et al, 2012;PRAGST, 2007;SCHEIDWEILER et al, 2012).…”

Section: A Abordagem Mais Utilizada Nas Análises De Drogas Recomendadunclassified

“…Portanto, há uma enorme demanda no desenvolvimento de métodos sensíveis, rápidos e confiáveis para confirmar a presença deste analito em amostras biológicas. A substância  9 -tetraidrocanabinol ( 9 -THC), cuja estrutura molecular está representada na Figura 1, é o composto mais significativo, devido às suas propriedades psicoativas, ao qual é atribuída a maioria dos efeitos da Cannabis (DE BRABANTER et al, 2013;FELLI et al, 2011;HAN et al, 2011;SCHEIDWEILER et al, 2012).…”

Section: Canabinóidesunclassified

Estudo da incerteza de medição em análises toxicológicas de substâncias psicoativas em urina

Eller¹

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Fast quantification of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid (THCA) using microwave-accelerated derivatisation and gas chromatography–triple quadrupole mass spectrometry

Cited by 22 publications

References 34 publications

Gas chromatographic analysis of naturally occurring cannabinoids: A review of literature published during the past decade

Gas chromatographic analysis of naturally occurring cannabinoids: A review of literature published during the past decade

Annual banned‐substance review: analytical approaches in human sports drug testing

Estudo da incerteza de medição em análises toxicológicas de substâncias psicoativas em urina

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