Fast dissolving films made of maltodextrins

Characterization of low cost orally disintegrating film (ODF)

“…Some authors developed fast dissolving oral films [2,11,30] , while others bioadhesive films [9,28] which can that take minutes or hours to release the active compound of interest. No official guidance time is referenced for oral fast disintegrating films/strips [1,3] .…”

Orodispersible dosage forms: biopharmaceutical improvements and regulatory requirements

“…[20,21]. Hot melt extrusion 139 (HME) is a suitable solvent-free alternative [19], even if the melting and thermal stability of the formulation 140 have to be preliminary evaluated [22]. A promising manufacturing technique is printing of the API onto a 141 plain film using inkjet printers, flexographic printers or a combination of both techniques [23,24].…”

Hot-Melt Extrusion (HME): From Process to Pharmaceutical Applications

“…Despite the fact that initial research developments have focused on the effects of formulation and processing variables on the properties of the final dosage forms, [9,30,31,34,35] more recent investigations have focused on the use of HME as a novel manufacturing technology of solid molecular dispersions through to the development of mini-matrices, taste masked formulations and also sustained release formulations as well as paediatric formulations [26,48]. Early work by De Brabander et al (2000) described the preparation of matrix mini-tablets which was followed by further investigations into the properties of sustained release mini-matrices manufactured from ethyl cellulose, HPMC and ibuprofen [32,33].…”