“…Despite the fact that initial research developments have focused on the effects of formulation and processing variables on the properties of the final dosage forms, [9,30,31,34,35] more recent investigations have focused on the use of HME as a novel manufacturing technology of solid molecular dispersions through to the development of mini-matrices, taste masked formulations and also sustained release formulations as well as paediatric formulations [26,48]. Early work by De Brabander et al (2000) described the preparation of matrix mini-tablets which was followed by further investigations into the properties of sustained release mini-matrices manufactured from ethyl cellulose, HPMC and ibuprofen [32,33].…”