Characterization of low cost orally disintegrating film (ODF)

Heinemann, Riana Jordão Barrozo; Vanin, Fernanda Maria; Carvalho, Rosemary Aparecida de; Trindade, Marco Antônio; Fávaro-Trindade, Carmen Sílvia

doi:10.1590/0104-1428.2409

Cited by 20 publications

(23 citation statements)

References 28 publications

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“…A similar effect was reported by Heinemann et al. [ 18 ] This increase in the strength of the material is due to the occurrence of crosslinking via interactions (hydrogen bonds) between the polymer chains. The occurrence of this type of crosslinking between starch and gums (guar and CMC), during extrusion, has already been reported by other authors.…”

Section: Resultssupporting

confidence: 80%

“…Heinemann et al [ 18 ] also observed surface roughness in films of starch blended with CMC and suggested this structure may be due to the retrogradation/partial crystallization of starch during the making of films. Tongdeesoontorn et al [ 19 ] reported homogeneous fracture surfaces in starch films containing 30% CMC.…”

Section: Resultsmentioning

confidence: 99%

“…At pH 7, comparing the films crosslinked with STMP, the SD of the sample containing starch and CMC (S/C/T) was 45% higher than that of the film containing only starch (S/T) (Table 1), highlighting the advantage of the mixed polymer matrix. Several factors can explain this result: first, the gum swelling capacity, which is greater than that of starch; [ 18 ] additionally, the fact that the structure of the networks formed by the crosslinks in the two systems is different, due to the difference in composition; and, finally, the reinforcement of the polymeric network promoted by the interaction between starch and CMC, via hydrogen bonds. Together, these effects increased the spaces for holding water.…”

Section: Resultsmentioning

confidence: 99%

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pHsensitive phosphate crosslinked films of starch‐carboxymethyl cellulose

Cagnin

Simões

Yamashita

et al. 2020

Polymer Engineering & Sci

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This work aims to develop hydrogel films of starch and carboxymethyl cellulose (CMC) crosslinked with sodium trimetaphosphate (STMP) and to characterize some of their properties. Starch and STMP (S/T), starch and CMC (S/C), and mixed (S/T/C) films were prepared by casting. The degree of substitution, morphology, swelling degree, FTIR, mechanical properties, and sorption isotherms were studied. Reticulated samples (S/T and S/T/C) showed the same degree of substitution (0.050 ± 0.001). All films presented homogeneous morphology, but the mixed film showed greater roughness. Crosslinking increased the swelling capacity of the mixed hydrogel at pH 7, although it remained decreased concerning the S/T hydrogel. However, this property was sensitive to pH variations. The mixed film (S/T/C) showed greater mechanical resistance. The casting process was efficient to produce hydrogel films of starch/CMC crosslinked with STMP and the general results demonstrated the advantages of the mixed hydrogel.

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Section: Resultssupporting

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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pHsensitive phosphate crosslinked films of starch‐carboxymethyl cellulose

Cagnin

Simões

Yamashita

et al. 2020

Polymer Engineering & Sci

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“…After that, it was dried in a hot air oven at 30 °C for 6 h to evaporate any residual solvent. After the films were dried, they were removed from the mold, cut in an appropriate sample size (15 mm × 15 mm × 0.6 mm), packed in aluminum foil, and stored in a desiccator (NaBr saline saturated solution, relative humidity = 58%) at 25 °C for at least 48 h until analysis [ 29 ]. The amount of gelatin in the film was determined as follows: The films (dimensions 15 mm × 15 mm × 0.6 mm) were weighed, then dried in a hot air oven at 100 °C to constant weight.…”

Section: Methodsmentioning

confidence: 99%

Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties

et al. 2021

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This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesive buccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatin from bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharmaceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride (PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higher elastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higher adhesion strength, while GAP shows higher work of adhesion. Both in vitro release study and in silico simulation indicated that processed films can provide effective drug transport through the buccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparison to the immediate-release tablets—indicating that the therapeutic drug dose can be markedly reduced.

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“…6. Saliva Stimulating Agents: [51][52][53] This causes increases in saliva production. This leads to an increase in the disintegration rates of the formulation.…”

Section: Film Forming Polymersmentioning

confidence: 99%

Untitled

2020

IJPSR

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In the development of a new drug molecule, there are many problems with respect to the dissolution, absorption, and bioavailability. Thus, formulation scientists are majorly focusing on the development of the formulation, which will increase the efficacy of the existing drugs. Oral dispersible films are one of such a novel approach. In given review article, the advantages of oral dispersible films over other oral dosage form and especially over oral dispersible tablets and their applications are discussed. In further part the major advantages regarding first-pass metabolism, disable patients, fast onset, etc., are covered. Furthermore, the overview of all the ingredients used in the formulation of fast dissolving films with the evaluation of these films is discussed in the given review article. Solvent casting, semisolid casting, hot-melt extrusion, solid dispersion extrusion, rolling are the methods which are employed, along with the evaluation parameters like thickness, tear resistance, dryness test of the prepared films are also explored in the article. This review article gives a complete overview of oral dispersible films and their novel approach in the formulation. INTRODUCTION: Among the delivery routes, the oral route is the most acceptable with respect to patient compliance. Many pharmaceutical firms have directed their research activity in reformulating existing drugs into new dosage forms. One such relatively new dosage form is the oral film, a thin film that is prepared using hydrophilic polymers that rapidly dissolves on the tongue or buccal cavity. Developing formulations for children has been a challenging task. Amongst other factors, the palatability of formulations of pediatric oral medications is one of the most significant factors influencing compliance with therapeutic regimens 1, 2 .

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Characterization of low cost orally disintegrating film (ODF)

Cited by 20 publications

References 28 publications

pHsensitive phosphate crosslinked films of starch‐carboxymethyl cellulose

pHsensitive phosphate crosslinked films of starch‐carboxymethyl cellulose

Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties

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