1976
DOI: 10.1002/neu.480070407
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Fast axonal transport in motor nerve regeneration

Abstract: This report describes the fast transport of [3H]-leucine-labeled proteins in regenerating rat sciatic motor nerves. A normal rate of fast transport (383 +/- 33 mm/day) was present in the regenerating sprouts, as well as in the central stumps. The rapidly transported proteins passed the level of axotomy without impediment, and accumulated in the endings of the regenerating sprouts, as shown by electron microscope autoradiography. In addition, transported proteins accumulated in terminal neuromas. The relative a… Show more

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Cited by 95 publications
(47 citation statements)
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References 45 publications
(50 reference statements)
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“…A similar result for glycoproteins labeled with [3H]fucose has been found in crushed rabbit hypoglossal nerve (Frizeil and Sjostrand, 1974). Total amounts of rapidly transported protein labeled with [3H]leucine have also been observed to increase in regenerating mammalian peripheral nerve (Griffin et al, 1976). Since transport of [3H] serotonin remains stably reduced during this period of time, this result may indicate that some of the [3H] fucosyl glycoprotein has been incorporated into organelles other than the transmitter vesicle as a consequence of axotomy.…”
Section: Methodsmentioning
confidence: 96%
“…A similar result for glycoproteins labeled with [3H]fucose has been found in crushed rabbit hypoglossal nerve (Frizeil and Sjostrand, 1974). Total amounts of rapidly transported protein labeled with [3H]leucine have also been observed to increase in regenerating mammalian peripheral nerve (Griffin et al, 1976). Since transport of [3H] serotonin remains stably reduced during this period of time, this result may indicate that some of the [3H] fucosyl glycoprotein has been incorporated into organelles other than the transmitter vesicle as a consequence of axotomy.…”
Section: Methodsmentioning
confidence: 96%
“…One hundred gCi of E L- [4,5 3H]leucine (specific activity 50 Ci/mmol; Radiochemical Cen-E tre, Amersham, UK) were injected into the area of the motor neurone ~. cell bodies through a glass micropipette with a tip diameter of 15 um, according to the method of Lasek [10] as modified by Griffin et al [11] r and the exact spinal coordinates of Forman and Berenberg [12]. Four to eight injections (total 3 t.t 0 were made each time (Fig.…”
Section: Axonal Transportmentioning
confidence: 99%
“…Microiqjection Procedures. Spinal cord injections were performed according to the method of Lasek (21) as modified by Griffin et al (22). The L4 and L5 segments of anesthetized adult rats were exposed by laminectomy of the T13 and L1 vertebrae.…”
mentioning
confidence: 99%