Fast analysis of glycosides based on HKUST-1-coated monolith solid-phase microextraction and direct analysis in real-time mass spectrometry

Abstract

Glycosides are a kind of highly important natural aromatic precursors in tobacco leaves. In this study, a novel HKUST-1-coated monolith dip-it sampler was designed for the fast and sensitive analysis of trace glycosides using direct analysis in real-time mass spectrometry. This device was prepared in two steps: in situ polymerization of monolith in a glass capillary of dip-it and layer-by-layer growth of HKUST-1 on the surface of monolith. Sufficient extraction was realized by immersing the tip to solution and in situ desorption was carried out by plasma direct analysis in real time. Compared with traditional solid-phase microextraction protocols, sample desorption was not needed anymore, and only extraction conditions were needed to be optimized in this method, including the gas temperature of direct analysis in real time, extraction time, and CH COONH additive concentration. This method enabled the simultaneous detection of six kinds of glycosides with the limits of detection of 0.02-0.05 μg/mL and the linear ranges covering two orders of magnitude with the limits of quantitation of 0.05-0.1 μg/mL. Moreover, the developed method was applied for the glycosides analysis of three tobacco samples, which only took about 2 s for every sample.

Yttria‐based sol–gel coating for capillary microextraction online coupled to high‐performance liquid chromatography

“…On the other hand, new SPME tools were developed but the CME has the advantage of online extraction and LC analysis . CME is a less laborious technique with few parameters to study . Resultantly, it becomes more reproducible than other SPME techniques.…”

Facile preparation of multifunctional carbon nanotube/magnetite/polyaniline nanocomposite offering a strong option for efficient solid‐phase microextraction coupled with GC–MS for the analysis of phenolic compounds

“…The key fragment of the SPME is the coating of fiber. Besides, new materials such as carbon‐based nanocomposites were prepared and used as coatings of fiber with noteworthy mechanical and chemical stability, enhanced selectivity and sensitivity for specified analytes .…”

Recent advances in metal‐organic frameworks and covalent organic frameworks for sample preparation and chromatographic analysis

“…As a class of POFs, MOFs have shown great potential for sample preparation methods. In this review, the applications of MOF materials for sample preparation are organized into the following approaches: SPE , DSPE , μ‐SPE , MSPE , solid‐phase microextraction (SPME) , headspace solid‐phase microextraction (HS‐SPME) , and other methods such as stir bar sorptive extraction (SBSE) and materials involving MIPs. Recent examples of the application of MOF materials in SPE are listed in Table , and examples of the application of MOF materials in SPME are listed in Table .…”