Fanconi syndrome in dog in the UK

Abstract

GB, including the AHVLA's Veterinary Investigation Diagnosis and Analysis (VIDA) process. These threats are assessed by the CEG and potentially significant ones that could have an impact on our livestock industry are reviewed by the Veterinary Risk Group, a multiagency UK group that further assesses, characterises and ranks each threat through a standardised peer-reviewed riskbased approach. Thirdly, this ranking is used to inform the response required, including if there is a need for active surveillance, which is then developed. With respect to BVD, occurrence of BVD type 2 in the UK in 2007 prompted active surveillance which is ongoing, and the recent outbreaks in continental Europe confirm its value given continual trade. All of the samples submitted for testing with the AHVLA's PCR which can differentiate BVD-1,-2 and border disease, and all positive Erns antigen tests, are further screened by PCR to confirm the type. Further sequencing is only undertaken on an individual case basis. With regard to trade, non-notifiable endemic diseases remain the responsibility of the importer, who should take advice from their veterinarian about the potential risks to their herds (and beyond) from importation. Mr Kerby's initiative is very welcome, especially as the emphasis in surveillance in GB moves more towards a more collaborative approach.

Reporting cases of Fanconi syndrome in dogs in the UK

“…CASES of Fanconi syndrome associated with the consumption of jerky treats have been reported in Australia and the USA (Thompson and others 2013, Carmichael and others 2014, US Food and Drug…”

Transient renal Fanconi syndrome in a Chihuahua exposed to Chinese chicken jerky treats

“…A measurement of urinary fractional electrolyte excretion would have been interesting here but was not carried out; increases in the fractional excretion of sodium, potassium and phosphorus have been reported with FS (6, 17). The initial hypoproteinemia and hypoalbuminemia are most likely a result of protein loss through the kidney.…”

“…Since 2007, there have been numerous cases of acquired FS in dogs receiving chicken, duck or sweet potato jerky treats in North America and Australia (2, 8, 10, 14, 17). Only recently, in 2014, was one case of jerky treat induced FS reported from the United Kingdom (6). Most of the treats contained products imported from China, but despite extensive investigations the causative toxin has not been found (8, 10).…”

Aminoaciduria Caused by Fanconi Syndrome in a Heifer

“…In particular, a deletion in the last exon of the FAN1 gene was strongly associated with Fanconi syndrome in a cohort of 78 Basenjis 11. Numerous cases of acquired and transient Fanconi syndrome in dogs were reported associated with copper storage hepatopathy or intoxication by numerous substances such as heavy metals (cadmium, lead), antibiotics (tetracycline, aminoglycosides) or jerky treats 3, 5, 7, 8, 12, 13, 14, 15. Recently, 4 cases of chlorambucil‐induced Fanconi syndromes in cats were reported 16.…”