Family history of cancer and the risk of cancer: a network of case–control studies

Turati, Federica; Edefonti, Valeria; Bosetti, Cristina; Ferraroni, Monica; Malvezzi, Matteo; Franceschi, Silvia; Talamini, Renato; Montella, Maurizio; Levi, Fabio; Maso, Luigino Dal; Serraino, Diego; Polesel, Jerry; Negri, Eva; Decarli, Adriano; Vecchia, Carlo La

doi:10.1093/annonc/mdt280

Cited by 73 publications

(70 citation statements)

References 29 publications

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“…The finding is also consistent with a case-control study in South-east Siberia (Zhivotovskiy et al, 2012), a report that a first degree family history of CRC in those undergoing colonoscopy was associated with the finding of pathologically significant lesions (Castiglione et al, 2012) and the outcome of a study involving a network of 13 case-control studies conducted across various parts of Italy and Switzerland (Turati et al, 2013). With regard to diet, the present study found no statistically significant associations between various dietary intakes and the risk of CRC.…”

Section: Discussionsupporting

confidence: 88%

XRCC1 Gene Polymorphism, Diet and Risk of Colorectal Cancer in Thailand

Poomphakwaen

Promthet²,

Suwanrungruang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Colorectal cancer (CRC) is one of the most common cancers worldwide. This study aimed to investigate the interaction between the presence of a polymorphism of the XRCC1 gene and known risk factors for colorectal cancer in Thailand. Materials and Methods: A hospital-based case-control study was conducted in Thailand. The participants were 230 histologically confirmed new cases and 230 controls matched by sex and age and recruited from the same hospital. Information about demographic characteristics, life style, and dietary habits was collected using structured interviews, and blood samples were taken which were used for the detection of a homozygous and heterozygous polymorphisms of XRCC1. Associations were assessed using multiple conditional logistic regression. Results: In the univariate analysis, factors found to be significantly associated with an increased risk for CRC were the presence of the XRCC1 AA homozygote (OR= 4.95; 95% CI: 1.99-12.3), a first degree family history of cancer (OR= 1.74; 95% CI: 1.18-2.58), and a high frequency of pork consumption (OR= 1.49; 95% CI: 1.00-2.21). Intakes of fish fruit and vegetables appeared to be protective factors, but the associations were not statistically significant. In the multivariate analysis only the XRCC1 AA homozygote polymorphism and a family history of cancer emerged as risk factors (OR= 4.96; 95% CI: 1.90-12.95 and OR=1.80; 95% CI: 1.18-2.72, respectively). Conclusions: While the XRCC1 AA homozygote and a family history of cancer were found to be associated with an increased risk of CRC, none of the dietary intake variables were clearly identified as risk or protective factors. There is a need for further research to determine the reasons for this.

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Section: Discussionsupporting

confidence: 88%

XRCC1 Gene Polymorphism, Diet and Risk of Colorectal Cancer in Thailand

Poomphakwaen

Promthet²,

Suwanrungruang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…This is consistent with a case-control study of the The CpG island methylator phenotype (CIMP) status of 3,119 primary populationbased colorectal cancer tumors from the multinational Colon Cancer Family Registry, reported that family history of CRC had decreased risk for CIMP, that represents a subset of colorectal cancer (Weisenberger et al, 2015). However, our result are in contrast with most previous studies which report family history of CRC to increase the risk for CRC (Johns and Houlston, 2001;Zhivotovskiy et al, 2012;Castiglione et al, 2012;Turati et al, 2013;Askling et al, 2001;Stegeman et al, 2013). Indeed, family history of any cancer has been shown to be associated with CRC in the Thai population (Sriamporn et al, 2007;Promthet et al, 2010;Poomphakwaen et al, 2014).…”

Section: Discussionsupporting

confidence: 89%

Risk Factors for Colorectal Cancer in Thailand

Poomphakwaen

Promthet²,

Suwanrungruang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Socioeconomic status is influential in oral cancer (Moles et al, 2008). Many other factors are possibly implicated in mouth, lip and oropharyngeal cancers, including immunosuppression (van Leeuwen et al, 2009), familial and genetic factors (Turati et al, 2013), diet (Garavello et al, 2009), marijuana use (Marks et al, 2014), and even exercise (Nicolotti et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Oral Potentially Malignant Disorders among Dental Patients: a Pilot Study in Jordan

Hassona¹,

Scully²,

Almangush³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: To determine the prevalence, types, and risk factors of oral potentially malignant disorders (OPMDs) among a group of Arab Jordanian dental patients, and to evaluate their awareness and attitudes toward early diagnosis and treatment. Materials and Methods: A total of 1,041 patients attending a University Hospital for dental care were examined for the presence of OPMDs. Histopathological examination was performed on all cases clinically diagnosed and patients were directly interviewed to evaluate their knowledge and attitudes toward early detection and treatment of oral cancer. Results: The prevalence of OPMDs overall was 2.8%. Lichen planus/lichenoid lesions were the most common lesions (1.8%) followed by leukoplakias (0.48%), chronic hyperplastic candidiosis (0.38%), and erythroplakia (0.096%). Smoking, alcohol, and age (>40 years) were the main identifiable risk factors. Patients with OPMDs displayed a general lack of awareness and negative attitudes towards early diagnosis and treatment. Conclusions: OPMDs among Arab dental patients are relatively uncommon and awareness about oral cancer among Jordanian dental patients is low. Interventions to improve public knowledge about oral cancer and attitudes toward early diagnosis and treatment are urgently indicated.

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Family history of cancer and the risk of cancer: a network of case–control studies

Abstract: Our results point to several potential cancer syndromes that appear among close relatives and may indicate the presence of genetic factors influencing multiple cancer sites.

Cited by 73 publications

References 29 publications

XRCC1 Gene Polymorphism, Diet and Risk of Colorectal Cancer in Thailand

XRCC1 Gene Polymorphism, Diet and Risk of Colorectal Cancer in Thailand

Risk Factors for Colorectal Cancer in Thailand

Oral Potentially Malignant Disorders among Dental Patients: a Pilot Study in Jordan

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