Familiality of Postpartum Depression in Unipolar Disorder: Results of a Family Study

Forty, Liz; Jones, Lisa; MacGregor, Stuart; Caesar, Sian; Cooper, Caroline; Hough, Andrea; Dean, Laura; Dave, Subodh; Farmer, Anne; McGuffin, Peter; Brewster, Shyama; Craddock, Nick; Jones, Ian

doi:10.1176/ajp.2006.163.9.1549

Cited by 139 publications

(105 citation statements)

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“…The findings of more family and personal psychiatric histories, and more life stress in women with PPD, supports previous findings in studies of women with postpartum depression (Dennis & Ross, 2006;Forty et al, 2006;Horowitz, Damato, Duffy, & Solon, 2005). In a study of concordance of PPD between 120 pairs of sisters, Forty et al, (2006) found that 42% shared a history of PPD, which highlights the importance of assessing family history.…”

Section: Calloutsupporting

confidence: 86%

“…Unlike the Mancini study, however, the current study did not find any significant differences in "nonbreastfeeding" and "less than a high school education" variables between women who scored ≥ 80 and those who scored < 80 on the PDSS. The differences may be due to having very few non-breastfeeding mothers (n = 8) and very few participants with less than a high school education (n = 1) in the current study.The findings of more family and personal psychiatric histories, and more life stress in women with PPD, supports previous findings in studies of women with postpartum depression (Dennis & Ross, 2006;Forty et al, 2006;Horowitz, Damato, Duffy, & Solon, 2005). In a study of concordance of PPD between 120 pairs of sisters, Forty et al, (2006) found that 42% shared a history of PPD, which highlights the importance of assessing family history.…”

supporting

confidence: 86%

“…The most prevalent risk factors for PPD include antepartum depression, personal psychiatric history, family psychiatric history, poor social support, and poverty (Forty et al, 2006;Logsdon & Usui, 2001). Up to 45% of women with antepartum depression develop PPD (Josefsson, Berg, Nordin, & Sydsjo, 2001).…”

Section: Callout 1 Sleep Qualitymentioning

confidence: 99%

“…Symptoms may start as early as 2 weeks and as late as one year, but usually peak between 6 and 12 weeks postpartum. Depressive symptoms have been reported to last up to 2 years postpartum (Mayberry, Horowitz, & Declercq, 2007).The most prevalent risk factors for PPD include antepartum depression, personal psychiatric history, family psychiatric history, poor social support, and poverty (Forty et al, 2006;Logsdon & Usui, 2001). Up to 45% of women with antepartum depression develop PPD (Josefsson, Berg, Nordin, & Sydsjo, 2001).…”

mentioning

confidence: 99%

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Sleep Quality in Women With and Without Postpartum Depression

Posmontier

2008

Journal of Obstetric, Gynecologic & Neonatal Nursing

117

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Objective-To compare and measure the effects of sleep quality on women with and without postpartum depression (PPD).Design-A case-control repeated measures matched pairs design. Setting-Home and obstetric office.Participants-Forty-six women who were 6 to 26 weeks postpartum. Two participants were dropped from the final analysis because they were outliers.Methods-Participants underwent wrist actigraphy at home for 7 consecutive days to measure sleep quality (sleep latency, wake after sleep onset, sleep efficiency, wake episodes). The Postpartum Depression Screening Scale measured depression severity. Psychosocial variables were collected during a screening interview. A structured clinical interview was used to diagnose PPD. Correlations, t-tests, and hierarchical multiple regressions were run to analyze data.Results-With the exception of wake episodes, sleep latency (B = 1.80, S.E. = 0.73, P<0.05), wake after sleep onset (B = 6.85, S.E. = 2.85, P<0.05), and thus sleep efficiency (B = −6.31, S.E. = 3.13, P<0.05) predicted PPD symptom severity.Conclusions-Women with PPD experienced poorer sleep quality than women without PPD, and sleep quality worsened with increasing PPD symptom severity. Clinicians need to address measures to improve sleep quality in depressed mothers to decrease symptom severity, and researchers need to develop interventions to facilitate better sleep quality in women with PPD. KeywordsSleep quality; postpartum depression; wrist actigraphy Callouts:1. In women with postpartum depression, nighttime breastfeeding demands, high-needs infants, and little nighttime support may negatively impact on sleep quality and further exacerbate depressive symptoms. 2.Women with PPD experienced poorer sleep quality than women without PPD, and sleep quality worsened with increasing PPD symptom severity. 3.Because poor sleep quality may negatively impact on PPD symptom severity, clinicians need to address measures to improve sleep quality and minimize nighttime sleep interruptions.Women are vulnerable to poor sleep quality in part because of dramatic hormonal fluctuations occurring during the reproductive cycle (Soares & Murray, 2006 NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript especially estrogen and progesterone mediate neurotransmitter levels in the brain responsible for maintaining the quality of sleep. Immediately after childbirth, precipitous decreases in estrogen and progesterone precipitate sleep disturbances in most women including difficulty initiating and maintaining sleep even in the absence of infant care (Lee, McEnany, & Zaffke, 2000). Postpartum women experience less total sleep time, less sleep efficiency (time asleep vs. time in bed), and decreased time to rapid eye movement (REM) compared to nonpostpartum women. In spite of being biologically programmed to be awake during the day and sleepy at night, new mothers normally experience less sleep and a 20% increase in wake time during the first 6 weeks postpartum (Goyal, Gay, & Lee, 2007). Because the same neurot...

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Section: Calloutsupporting

confidence: 86%

supporting

confidence: 86%

Section: Callout 1 Sleep Qualitymentioning

confidence: 99%

mentioning

confidence: 99%

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Sleep Quality in Women With and Without Postpartum Depression

Posmontier

2008

Journal of Obstetric, Gynecologic & Neonatal Nursing

117

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“…On the other hand better identifying variations of clinical variables in different subgroups may provide predictions of clinical traits to be candidates for endophenotype concept. Familial clustering of a symptom may indicate a shared genetic origin and puerperal mood disorders are instances shown to be largely familial traits (6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Distinct clinical characteristics of familial and solitary patients with bipolar disorder

Atagün¹,

Cevahirli²,

Kara³

et al. 2011

JMOOD

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İki uçlu bozukluğu olan ailesel ve münferit hastaların farklı klinik özellikleri Amaç: İki uçlu bozukluk da dahil majör ruhsal bozukluklar ailelerde kümelenmektedirler. Ailesel olmayan, tek vakalar da görülmektedir ve ailesel ve ailesel olmayan vakalar klinik özellikler bakımından farklılık gösterebilirler. Aileselliği dikkate alan çalışmaların büyük bölümü aynı aileden hastalarda hastalığın benzer olan ve olmayan özelliklerini incelemişlerdir. Farklı ailelerden olan ve ailesel özelliklerine göre hastalık özelliklerinin karşılaştırıldığı yeterince çalışma yoktur. Bu çalışmada ailesel olan ve olmayan tip I iki uçlu bozukluğu olan hastaların klinik özellikler açısından incelenmesi ve karşılaştırılması amaçlanmıştır. Yöntem: Bu araştırma Bakırköy Prof. Dr. Mazhar Osman Ruh ve Sinir Hastalıkları Eğitim ve Araştırma Hastanesine bağlı Raşit Tahsin Duygudurum Merkezi'nde tedavi görmekte olan hastalarla yapıldı. İki uçlu bozukluğu olan 112 hastanın (69 kadın, 43 erkek, ortalama yaş: 41.54±11.19, dağılım aralığı: 22-75, ailesinde hastalık öyküsü olan 64, olmayan 48 hasta) tıbbi kayıtları incelendi ve veriler hastalardan ve birinci derece akrabalarından telefonla teyit edildi. Ailesinde hastalık öyküsü olmayan hastaların ailelerine sorularak ailelede başka hastanın olmadığı doğrulandı. Bulgular: Psikiyatrik ekhastalıklar, doğum sonrası depresyon oranları, nikotin bağımlılığı, karma hastalık dönemi geçirmiş hasta sayısı ve halen antipsikotik kullanan hasta sayısı aile öyküsü olan hasta grubunda istatistiksel olarak anlamlı derecede daha fazla oldukları saptanan özelliklerdi. Hastalık başlangıç yaşı, hastalık dönemi sayıları ve hastaneye yatış sayıları açısından gruplar arasında fark saptanmadı. Sonuç: Psikiyatrik ekhastalık, doğum sonrası depresyon, karma hastalık dönemleri ve sigara kullanma ailesinde hastlalık öyküsü olan hastalarda daha fazla oranda bulundukları tespit edilen klinik özelliklerdir ve iki uçluluk ile ilişkilidirler. Psikiyatrik ekhastalık ve postpartum dönem geçirmeye yatkınlık aile öyküsü olan hastalarda daha fazla görülmesi beklenebilir. Fakat klinik özelliklerin gruplarda farklılık gösterip göstermediğinin belirlenebilmesi için daha başka büyük örneklemli çalışmalar da gerekmektedir.

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Family History of Psychiatric Disorders as a Risk Factor for Maternal Postpartum Depression

et al. 2022

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ImportanceCurrent evidence on the association between family history of psychiatric disorders and postpartum depression is inconsistent; family studies have identified familial risk of postpartum depression, whereas systematic reviews and umbrella reviews, compiling all risk factors for postpartum depression, often have not.ObjectiveTo investigate the association between family history of psychiatric disorders and risk of developing postpartum depression within 12 months post partum.Data SourcesLiterature searches were conducted in PubMed, Embase, and PsycINFO in September 2021 and updated in March 2022, accompanied by citation and reference search.Study SelectionStudies eligible for inclusion comprised peer-reviewed cohort and case-control studies reporting an odds ratio (OR) or sufficient data to calculate one for the association between family history of any psychiatric disorder and postpartum depression. Study selection was made by 2 independent reviewers: title and abstract screening followed by full-text screening.Data Extraction and SynthesisReporting was performed using the MOOSE checklist. Two reviewers independently extracted predefined information and assessed included studies for risk of bias using the Newcastle-Ottawa Scale. Data were pooled in a meta-analysis using a random-effects model. Heterogeneity was investigated with meta-regression, subgroup, and sensitivity analyses. Publication bias was investigated using a funnel plot, and GRADE (Grading of Recommendations Assessment, Development, and Evaluation) was used to evaluate the overall certainty of the findings.Main Outcomes and MeasuresThe primary outcome was the pooled association between family history of psychiatric disorders and postpartum depression.ResultsA total of 26 studies were included, containing information on 100 877 women. Meta-analysis showed an increased OR of developing postpartum depression when mothers had a family history of psychiatric disorders (OR, 2.08; 95% CI, 1.67-2.59; I2 = 57.14%) corresponding to a risk ratio of 1.79 (95% CI, 1.52-2.09), assuming a 15% postpartum depression prevalence in the general population. Subgroup, sensitivity, and meta-regression analyses were in line with the primary analysis. The overall certainty of evidence was deemed as moderate according to GRADE.Conclusions and RelevanceIn this study, there was moderate certainty of evidence for an almost 2-fold higher risk of developing postpartum depression among mothers who have a family history of any psychiatric disorder compared with mothers without.

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Familiality of Postpartum Depression in Unipolar Disorder: Results of a Family Study

Cited by 139 publications

References 0 publications

Sleep Quality in Women With and Without Postpartum Depression

Sleep Quality in Women With and Without Postpartum Depression

Distinct clinical characteristics of familial and solitary patients with bipolar disorder

Family History of Psychiatric Disorders as a Risk Factor for Maternal Postpartum Depression

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