Familial Risk of Dementia Associated With a Biologic Subtype of Alzheimer's Disease

Zubenko, George S.; Huff, F. Jacob; Beyer, Julia; Auerbach, Jonathan; Teply, Ivana

doi:10.1001/archpsyc.1988.01800340011001

Cited by 50 publications

(12 citation statements)

References 38 publications

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“…- 21 In the current study, this membrane phenotype was also associated with a decreased prevalence of hypertension, an association that became even stronger when Platelet membrane fluidity subtype (increased=l, normal=0) was predicted in multiple logistic regression model from risk factors for stroke. Age, cardiac index, and ischemic score were coded as continuous variables.…”

supporting

confidence: 52%

“…Our previous reports suggest that this difference arises from an earlier age of onset of cognitive impairment in the former subgroup. 3 -8 ' 21 Furthermore, the patients with increased membrane fluidity were significantly less likely to have a history of hypertension than the normal fluidity subgroup. A history of hypertension remained a significant independent predictor of membrane fluidity classification in a logistic regression analysis that simultaneously controlled for the effects of age and other risk factors for stroke (Table 4).…”

Section: Resultsmentioning

confidence: 95%

“…22 Moreover, this membrane phenotype is present at increased prevalence among asymptomatic first-degree relatives of probands with Aizheimer's disease who manifest increased platelet membrane fluidity 8 and predicts an earlier onset of cognitive impairment in those first-degree relatives who develop primary dementia. 21 In a segregation analysis employing data from 95 individuals from 14 pedigrees, at least 80% of the variation in platelet membrane fluidity could be explained by the inheritance of a single major locus. 23 These data suggest that the platelet membrane abnormality antedates The focus of the current study is to explore the basis for the decreased prevalence of focal EEG findings in the subgroup of patients with Alzheimer's disease who have increased platelet membrane fluidity.…”

mentioning

confidence: 99%

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Risk factors for stroke as predictors of platelet membrane fluidity in Alzheimer's disease.

Zubenko

Brenner

Teply

1991

Stroke

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We have previously reported that increased platelet membrane fluidity identifies a subgroup of patients with Alzheimer's disease who have distinct clinical features including an earlier age of symptomatic onset, a more rapidly progressive cognitive decline, and a decreased prevalence of focal electroencephalographic findings. In the current study, these patients also exhibited a decreased prevalence of risk factors for stroke compared with patients who had normal platelet membrane fluidity. Our findings suggest that the platelet membrane abnormality describes a clinical subgroup of patients with Alzheimer's disease who are less likely to have coexisting cerebrovascular disease than the remaining patients who meet clinical consensus criteria for probable Alzheimer's disease. (Stroke 1991;22:997-1003)

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supporting

confidence: 52%

Section: Resultsmentioning

confidence: 95%

mentioning

confidence: 99%

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Risk factors for stroke as predictors of platelet membrane fluidity in Alzheimer's disease.

Zubenko

Brenner

Teply

1991

Stroke

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“…There is growing recognition for more than a unitary process in AD and the possibility of subtypes of the disease including early and late onset forms (Filley et al, 1986;Seltzer and Sherwin, 1983) and familial and non-familial forms (St George Hyslop et al, 1987;Zubenko et al, 1988). The earlier study findings of more plaques and tangles in brain tissue of patients with AD were found to be non-specific in subsequent studies that reported the presence of increased numbers of plaques and tangles in brains of older non-demented subjects as well (Blass et al, 1991).…”

Section: Alzheimer's Disease and Related Disordersmentioning

confidence: 99%

Evolution of research in geriatric psychiatry

Kalayam

Shamoian

1993

Int J Geriat Psychiatry

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During the past 30 years the knowledge base of geriatric psychiatry has grown exponentially to replace the folklore and myths which for many years pervaded the as yet undefined field of geriatric psychiatry. The advances in geriatric psychiatry, as with many areas of medicine, have been fostered by the appearance of sophisticated technologies including analytic chemistry techniques, functional and structural brain‐imaging studies and molecular biology. However, many of these advances could not have been achieved without the supported initiatives in education and research in geriatric psychiatry by major agencies such as the National Institute of Mental Health Center for Studies of Mental Health of the Aging and the National Institute for Aging. For example, the number of geriatric specialty training programs in the United States increased to more than 30 between 1978 and 1989 as compared to the existence of only one prior to 1978 in the setting of a medical school (Cohen, 1989). These clinical and research training programs continue to the present day and are not only the source of the future researchers in geriatric psychiatry but also the ‘centres’ of research activity in areas such as the mood disorders, dementias, late onset schizophrenia, anxiety, and other psychiatric disorders of the elderly which are reviewed in this issue of the Journal.

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“…Zubenko and Teply's [8] explanation of this fact was that increased PMF represents a sub-type of the dis order with a more rapidly progressive course. Zubenko et al [10] showed that the number of relatives with dementia was the same in patients with or without increased PMF but the age of onset of the disorder in affected relatives was earlier in the group with the abnor mality. Eagger et al [II] found that increased PMF was not a marker for familial AD and found a correlation between cognitive function and degree of fluidity in patients without a family history.…”

Section: Introductionmentioning

confidence: 98%

Clinical Diagnosis of Alzheimer's Disease

Burns¹

1991

Dement Geriatr Cogn Disord

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There are a number of ways in which a clinical diagnosis of dementia of the Alzheimer type can be made – the application of clinical criteria is the commonest but ancillary techniques such as neuroimaging, peripheral markers and neurophysiological investigations are helpful. The NINCDS/ADRDA criteria are the most consistent in correctly predicting, during life, who will have the neuropathological findings of Alzheimer''s disease and as such represent the gold standard for clinical diagnosis. Platelet membrane fluidity and the results of nasal biopsy may also be helpful but the specificity of abnormalities for Alzheimer''s disease has yet to be established. Computerised tomography and single photon emission tomography are the two most applicable and widely available neuroimaging techniques and, with single photon emission tomography, characteristic patterns of blood flow distribution are seen in Alzheimer''s disease. Even with the application of clinical guidelines and appropriate use of ancillary investigations, there is still diagnostic misclassification in up to 20% of cases for the refinement of clinical criteria and prospective clinico-pathological studies along with clinical criteria for other types of dementia are required.

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Familial Risk of Dementia Associated With a Biologic Subtype of Alzheimer's Disease

Cited by 50 publications

References 38 publications

Risk factors for stroke as predictors of platelet membrane fluidity in Alzheimer's disease.

Risk factors for stroke as predictors of platelet membrane fluidity in Alzheimer's disease.

Evolution of research in geriatric psychiatry

Clinical Diagnosis of Alzheimer's Disease

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