Risk factors for stroke as predictors of platelet membrane fluidity in Alzheimer's disease.

Zubenko, George S.; Brenner, Richard P.; Teply, Ivana

doi:10.1161/01.str.22.8.997

Cited by 6 publications

(2 citation statements)

References 42 publications

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“…In view of the findings of a recent study, in which an increased platelet membrane fluidi ty in a subset of patients with Alzheimer's dis ease led to a favourable risk factor profile for the development of stroke compared to pa tients with a normal platelet membrane fluidi ty [34], we cannot conclude that the use of aspirin in patients with thromboembolic dis ease is always of benefit.…”

Section: Discussionmentioning

confidence: 76%

Aspirin-Induced Conformational Changes in Platelet Membrane in Subjects with Stroke

Hasan

Jackson²,

Sinclair³

1995

Gerontology

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Objectives of this case-control study were (1) to examine membrane conformational changes and dynamics in platelets of patients with stroke prior to and following short-term aspirin administration and (2) to investigate changes in platelet membrane fluidity which may be associated with the ageing process. The study population consisted of 10 patients with ischaemic stroke (age range 61–92, mean 76 years; 6 females and 4 males) 9 age- and sex-matched controls (age range 64–88, mean 73 years; 5 females and 4 males), and 8 healthy young controls (age range 22–39, mean 32 years; 4 females and 4 males). The patients were recruited from the medical and geriatric wards, whereas both young and old controls were recruited from hospital staff and the local community. Aspirin, at a dose of 150 mg/day, was administered to all three groups for 7 days. The order parameter S, which is an index of membrane fluidity and conformation, was measured by the techniques of spin labelling and electron spin resonance spectroscopy on platelets from venous blood samples from patients prior to (within 48 h of admission) and following 7 days of aspirin therapy and from venous blood samples from both young and old controls before and after 7 days of oral aspirin therapy. There was an age-relateted decrease in platelet membrane fluidity. There was no significant difference in the value of ‘S’ between patients with ischaemic stroke and old controls. Treatment with aspirin led to a significant decrease in membrane fluidity in both patients and old controls, but had no apparent effect on the platelet membrane fluidity of younger controls. We conclude that the ageing process is associated with a decrease in platelet membrane fluidity and that aspirin therapy leads to a further significant fall in membrane fluidity in both patients with stroke disease and old controls. No apparent effect on the platelet membrane fluidity of younger controls was observed.

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Section: Discussionmentioning

confidence: 76%

Aspirin-Induced Conformational Changes in Platelet Membrane in Subjects with Stroke

Hasan

Jackson²,

Sinclair³

1995

Gerontology

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“…In cross-sectional studies AD patients with increased PMF suffered from a n earlier (by approximately 5 years) symptomatic onset,333,337 a more rapidly progressive decline,333 a lower prevalence of focal electroencephalographic and fewer risk factors for stroke. 339 In light of these findings, the AD subgroup with increased PMF may represent a comparatively homogeneous group of individuals whose dementias are more likely than those of AD patients with normal PMF to have a purely degenerative origin, instead of resulting from ischemia or a mixture of causes. Evaluations of the cognitive impairments of patients with AD have not revealed any specific cognitive deficits-or spectrum of cognitive deficits-linked to increased PMF.340…”

Section: Peripheral Cellsmentioning

confidence: 92%

Molecular Neurobiology of Alzheimer's Disease (Syndrome?)

Zubenko

1997

Harvard Review of Psychiatry

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Alzheimer's disease (AD) is the most common cause of mental impairment in late life and is estimated to afflict nearly half of older adults who live beyond age 85. Although progressive dementia is a cardinal feature of patients with AD, age at symptomatic onset, rate of progression, and specific signs and symptoms vary widely. This clinical heterogeneity appears to arise in part from interindividual differences in the precise molecular events that contribute to the pathophysiology of AD, as well as from nonuniform or multifocal patterns of brain degeneration that occur during the early to middle stages of dementia. The goals of this review are to cover the substantial progress that has been made over the past 5 years in the major thematic areas of research in AD and to assemble these individual findings into a more integrated picture of the pathophysiology of the disorder. The results may have important implications for the treatment or prevention of AD.

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Peripheral Markers in Alzheimer’s Disease

Sweet¹,

Zubenko²

1994

Dementia

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Risk factors for stroke as predictors of platelet membrane fluidity in Alzheimer's disease.

Cited by 6 publications

References 42 publications

Aspirin-Induced Conformational Changes in Platelet Membrane in Subjects with Stroke

Aspirin-Induced Conformational Changes in Platelet Membrane in Subjects with Stroke

Molecular Neurobiology of Alzheimer's Disease (Syndrome?)

Peripheral Markers in Alzheimer’s Disease

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