Familial Migraine in a Mexican Population

Vilatela, M E Alonso; Pedroza, Felipe García; Ziegler, Dewey K.; Méndez, Alfonso

doi:10.1159/000110908

Cited by 11 publications

(2 citation statements)

References 5 publications

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“…Epidemiological studies show that migraine aggregates within families 1‐3 . The relative risk (RR) of migraine in family members of episodic migraine probands, compared with those of controls, ranges from 1.5 to 19.3 in different casuistics 4‐9 . Aggregation seems to increase as a function of disease severity, 7 and early onset of migraine in the proband as well as the severity of migraines is associated with higher levels of family aggregation 10 .…”

mentioning

confidence: 99%

Frequency of Headaches in Children is Influenced by Headache Status in the Mother

Arruda

Guidetti²,

Galli³

et al. 2010

Headache

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mentioning

confidence: 99%

Frequency of Headaches in Children is Influenced by Headache Status in the Mother

Arruda

Guidetti²,

Galli³

et al. 2010

Headache

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“…The relative risk of migraine in family members of episodic migraine probands, compared with those of controls, ranges from 1.5 to 19.3 in different casuistics [8–13]. Aggregation seems to increase as a function of disease severity [11], and early onset of migraine in the proband as well as the severity of migraines is associated with higher levels of family aggregation [14].…”

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confidence: 99%

Migraine and behavior in children: influence of maternal headache frequency

Arruda¹,

Bigal

2012

J Headache Pain

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We took advantage of a large population study in order to measure child behavior, as captured by the Child Behavior Checklist (CBCL) as a function of headache status in the children and their mothers. Of the target sample, consents and analyzable data were obtained from 1,856 families (85.4 %). Headache diagnoses were defined according to the second edition of the International Classification of Headache Disorders, and behavioral and emotional symptoms were assessed by the validated Brazilian version of the CBCL. We calculated the relative risk of abnormalities in the CBCL domains as a function of headache status in the children, after adjusting by a series of main effect models. Children with migraine were more likely to present abnormal scores in several of the CBCL scales, relative to children without migraine, and maternal migraine status contributed little to the model. However, when the mother had daily headaches, both children with and without migraine had similar CBCL scores. In multivariate analyses, migraine status in the children predicted CBCL scores (p < 0.01). Headache status and headache frequency in the mother did not predict CBCL scores in children with migraine but predicted in children without migraine (p < 0.01). The burden of migraine to the family is complex. Children with migraine are more likely to have behavioral and emotional symptoms than children without migraine. Children without migraine may be affected, in turn, by frequent headaches experienced by their mothers.

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Familial risk of migraine: A population‐based study

Stewart

Staffa

Lipton

et al. 1997

Annals of Neurology

140

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Estimates of familial aggregation of migraine have varied considerably due, in part, to methodological differences among studies. We concluded a population-based study of 73 clinically confirmed probands with migraine, 72 matched control probands, and 511 of their first-degree relatives, all of whom were directly interviewed. The risk of migraine was 50% more likely in relatives of migraine probands than in relatives of controls. Migraine risk was considerably higher among relatives of probands with disabling migraine compared with relatives of probands with minimal disability. Moreover, for probands with minimal disability, no excess risk of migraine in female relatives was observed. Finally, in relatives of male migraine probands, there appears to be an excess risk of migraine with aura. A borderline significant relative risk of 4.04 was observed. No excess risk was observed among relatives of male probands who had migraine without aura. This study suggests that familial factors (environment related to the family or genetic factors) account for less than one-half of all migraine cases in the population. Degree of disability in the proband appears to influence familial risk. These results suggest that the development of migraine is determined by complex genetic as well as environmental factors.

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Familial Migraine in a Mexican Population

Cited by 11 publications

References 5 publications

Frequency of Headaches in Children is Influenced by Headache Status in the Mother

Frequency of Headaches in Children is Influenced by Headache Status in the Mother

Migraine and behavior in children: influence of maternal headache frequency

Familial risk of migraine: A population‐based study

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