Familial risk of migraine: A population‐based study

Stewart, Walter F.; Staffa, Judy A.; Lipton, Richard B.; Ottman, Ruth

doi:10.1002/ana.410410207

Cited by 140 publications

(111 citation statements)

References 24 publications

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“…Risk factors for having the condition of migraine-An increased risk of having migraine headache has been noted among people who have a first degree relative with migraine [43,48,50] and between twins, with a pair-wise concordance rate being significantly higher in monozygotic twins (43%) compared to dizygotic twins (12%) [51]. This suggests that there is some underlying genetic factor(s) that predispose people to developing the condition of migraine headaches.…”

Section: Risk Factors In Migraine Headachementioning

confidence: 99%

Neurovascular Pains: Implications of Migraine for the Oral and Maxillofacial Surgeon

Nixdorf

Velly

Alonso

2008

Oral and Maxillofacial Surgery Clinics of North America

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SynopsisEpidemiological studies have shown that migraine headaches are a common finding in the general population, often associated with a high degree of disability. Additionally, migraine has a reported co-morbidity with other medical conditions, most notably with chronic pains such as temporomandibular disorders (TMD). The pathophysiological mechanisms involved with migraine are suggestive of an increased and prolonged hyperexcitability to stimuli, especially within the trigeminal distribution. Since migraine is mediated via branches of the trigeminal nerve it has the potential to mimic other types of pains, such as toothache or sinusitis. Therefore, it is recommended that oral and maxillofacial surgeons be familiar with the diagnostic criteria for migraine headaches in order to identify and appropriately treat such individuals who present to their clinics. KeywordsMigraine Headache; Diagnosis; Epidemiology; Pathophysiology; Oral Surgery; Pain IntroductionNeurovascular pains, otherwise known as headaches, are a group of pain disorders that are felt as cephalalgias, or pains in the head. Likely they are a heterogeneous group of disorders that share a common anatomic region of presentation, the head, but have somewhat separate pathophysiological mechanisms. For the most part, neurovascular pains are currently viewed Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. as arising from neuronal firing of nociceptors associated with intracranial blood vessels and dura. For this reason these pain disorders were historically referred to as 'vascular pains' [1], but further research has identified both peripheral and central aspects of the nervous system are playing crucial roles in the initiation and perpetuation of these pains [2,3]. This brought about a change in nomenclature regarding headache, which are now referred to as 'neurovascular pains disorders', stressing the neuropathic aspect of migraine. (Table 1) Research has continued to more closely associate headache disorders with neuropathic mechanisms, which is starting to result in a shift in how headaches are viewed -from both clinical and research perspectives. In the midst of this paradigm shift this article seeks to provide an overview of the epidemiologic data and pathophysiologic mechanisms of one type of neurovascular pain, that being migraine headaches. The reason for focusing on migraine headache is because they are known to be common in the population [4,5] and have been reported to have the most disability associated with them [6,7], making migraine headache the prototypic neurovascular pain disorder. Migraine hea...

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Section: Risk Factors In Migraine Headachementioning

confidence: 99%

Neurovascular Pains: Implications of Migraine for the Oral and Maxillofacial Surgeon

Nixdorf

Velly

Alonso

2008

Oral and Maxillofacial Surgery Clinics of North America

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“…6 Migraine frequently runs in families, but family and segregation studies have produced conflicting results with respect to the mode of inheritance. [7][8][9][10] From a large proband-oriented clinical study 6 it was inferred that migraine with aura is largely or exclusively determined by genetic factors, whereas migraine without aura seems to be caused by a combination of both genetic and environmental factors. Thus migraine is a multifactorial disorder.…”

Section: Migraine a Multifactorial Disordermentioning

confidence: 99%

Migraine, ataxia and epilepsy: a challenging spectrum of genetically determined calcium channelopathies

Terwindt

Ophoff²,

Haan

et al. 1998

Eur J Hum Genet

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Clinical and genetic heterogeneity as well as influence of environmental factors have hampered identification of the genetic factors which are involved in episodic diseases such as migraine, episodic ataxia and epilepsy. The study of rare, but clearly genetically determined subtypes, may help to unravel the pathogenesis of the more common forms. Recently, different types of mutation in the brain-specific P/Q type calcium channel α 1A subunit gene (CACNA1A) on chromosome 19p13 were shown to be involved in three human disorders: familial hemiplegic migraine (FHM), episodic ataxia type 2 (EA2), and chronic spinocerebellar ataxia type 6 (SCA6). In addition, evidence is accumulating that the same gene is also involved in the common forms of migraine with and without aura. In the tottering and leaner mouse, which are characterised by epilepsy and ataxia, similar mutations were identified in the mouse homologue of the calcium channel α 1A subunit gene. These findings add to the growing list of episodic (and now also chronic) neurological disorders, which are caused by inherited abnormalities of voltage-dependent ion channels. The findings in migraine illustrate that rare, but monogenic variants of a disorder, may be successfully used to identify candidate genes for the more common, but genetically more complex, forms.

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“…15 From a pathophysiological perspective, central neuronal hyperexcitability underlies susceptibility to and the development of migraine episodes. 16,17 The broad evidence base for this as an aetiology suggests a multifactorial causation, with amino acids, calcium channels, magnesium depletion and controlling genes all being implicated.…”

Section: Aetiologymentioning

confidence: 99%