Frequency of Headaches in Children is Influenced by Headache Status in the Mother

Arruda, Marco A.; Guidetti, Vincenzo; Galli, Federica; Albuquerque, Regina; Bigal, Marcelo E.

doi:10.1111/j.1526-4610.2010.01677.x

Cited by 33 publications

(22 citation statements)

References 38 publications

(55 reference statements)

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“…No significant associations were found with respect to parental GP, non-migraine headaches, and other FPS. These results were surprising when compared to previous research on this topic, and may be due to our relatively small sample size 53–56…”

Section: Discussioncontrasting

confidence: 84%

In search of risk factors for chronic pain in adolescents: a case–control study of childhood and parental associations

Coenders¹,

Chapman²,

Hannaford³

et al. 2014

JPR

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ObjectivesThis study was designed to investigate whether an individual and parental history of functional pain syndromes (FPS) is found more often in adolescents suffering from chronic pain than in their pain-free peers.MethodsOur case–control study involved 101 adolescents aged 10–18 years. Cases were 45 patients of the Chronic Pain Clinic at Sydney Children’s Hospital with diverse chronic pain disorders. Controls consisted of 56 adolescent volunteers who did not have chronic pain. Adolescents and their parents filled out questionnaires assessing demographic data as well as known and potential risk factors for chronic pain. A history of FPS was assessed by questionnaire, including restless legs syndrome (RLS). Chi-squared tests and t-tests were used to investigate univariate associations between chronic pain in adolescents and lifetime prevalence of FPS. Logistic regression was used to test multivariate associations, while controlling for possible confounders.ResultsMigraine, non-migraine headaches, recurrent abdominal pain (RAP), and RLS were reported significantly more frequently in cases than controls (P-values of 0.01, <0.001, 0.01, and 0.03, respectively). Parental migraine, RAP, and RLS were also significantly associated with adolescent chronic pain in the multivariate analyses. Individual history of migraine, non-migraine headaches, and RAP, along with parental history of RAP and depression significantly accounted for 36%–49% of variance in chronic pain. Other associations with chronic pain were generally in accordance with previous reports.DiscussionIt may be helpful when assessing a child who has chronic pain or is at risk of chronic pain, to enquire about these associations. Based on the current findings, an individual history of migraine, non-migraine headaches, and RAP, as well as parental migraine, RAP, and RLS are symptoms that are of particular relevance to assess.

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Section: Discussioncontrasting

confidence: 84%

In search of risk factors for chronic pain in adolescents: a case–control study of childhood and parental associations

Coenders¹,

Chapman²,

Hannaford³

et al. 2014

JPR

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“…Sixteen population studies [5,7,8,13,24,33,37,43,48,49,63,65,72,79,89,90] examined offspring pain outcomes, although not all provided data sufficient for inclusion in the meta-analysis. Meta-analysis of six studies [13,24,33,37,43,72] ( N = 9965 offspring) providing appropriate data for meta-analysis found that offspring of mothers with chronic pain were more likely to report pain complaints compared to offspring of control mothers ( OR = 1.59, 95% CI [1.37, 1.85], Z = 6.00, p < 0.00001, I 2 = 44%).…”

Section: Resultsmentioning

confidence: 99%

“…One study examining mother-reported offspring pain complaints found that offspring of mothers with chronic daily headaches were more likely to have chronic daily headaches compared to offspring of mothers with no lifetime history of headaches [7]. The remaining studies used dissimilar parental pain or control definitions and could not be combined with the other studies [8,48,65], did not report associations between parental pain and offspring pain despite measuring these variables [5,49,90], or reported data in a format that could not be combined with the other meta-analyzed studies (e.g., regression coefficients that could not be combined with the OR data in the generic inverse variance analysis)[79,89].…”

Section: Resultsmentioning

confidence: 99%

Offspring of parents with chronic pain

Higgins

Birnie

Chambers

et al. 2015

Pain

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Offspring of parents with chronic pain may be at risk for poorer outcomes than offspring of healthy parents. The objective of this research was to provide a comprehensive mixed-methods, systematic synthesis of all available research on outcomes in offspring of parents with chronic pain. A systematic search was conducted for published articles in English examining pain, health, psychological, or family outcomes in offspring of parents with chronic pain. Fifty-nine eligible articles were identified (31 population-based, 25 clinical, 3 qualitative), including offspring from birth to adulthood and parents with varying chronic pain diagnoses (e.g., mixed pain samples, arthritis). Meta-analysis was used to synthesize the results from population-based and clinical studies, while meta-ethnography was used to synthesize the results of qualitative studies. Increased pain complaints were found in offspring of mothers and of fathers with chronic pain, and when both parents had chronic pain. Newborns of mothers with chronic pain were more likely to have adverse birth outcomes, including low birthweight, preterm delivery, caesarean section, intensive care admission, and mortality. Offspring of parents with chronic pain had greater externalizing and internalizing problems and poorer social competence and family outcomes. No significant differences were found on teacher-reported externalizing problems. The meta-ethnography identified six key concepts (developing independence, developing compassion, learning about health and coping, missing out, emotional health, and struggles communicating with parents). Across study designs, offspring of parents with chronic pain had poorer outcomes than other offspring, although the meta-ethnography noted some constructive impact of having a parent with chronic pain.

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“…In a personal series, there was a family history of CDH in 11 (16%) of 70 children with CDH [20]. The risk of CDH in children is increased almost 13-fold when the mother has CDH [21]. Nongenetic factors, such as learned behavior, may play a role.…”

Section: Geneticsmentioning

confidence: 92%

Chronic Daily Headache in Children and Adolescents

Seshia

2011

Curr Pain Headache Rep

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Chronic daily headache (CDH) may be primary or secondary. Secondary causes can be suspected through "red flags" in the history and examination. With a prevalence of at least 1% and several associations, primary CDH is a common, often complex, chronic pain syndrome in children and adolescents. The intricate associations between stressors, psychiatric disorders (especially anxiety and depression), and CDH can be explained by "the limbically augmented pain syndrome" proposed by Rome and Rome. Disorders of sleep and other pain syndromes also may co-occur. For these reasons, a multiaxial classification is ideal. Many with primary CDH have features of both chronic migraine and chronic tension-type headache, contributing to confusion in subtyping. Primary CDH is often transformed from a primary episodic headache type, stressors being most responsible. Genetic factors also may facilitate chronification. Management should be biopsychosocial, family-centered, and often multidisciplinary, drugs being only one component. Treatment is still based on consensus, not evidence. Girls, migraineurs, and those with psychiatric comorbidity, medication overuse, and CDH onset before the age of 13 years and lasting for 2 years or longer, are at high risk for persistence; hence, such patients should be followed up into adult life. A classification for CDH should be included in the third edition of the International Classification of Headache Disorders.

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Frequency of Headaches in Children is Influenced by Headache Status in the Mother

Abstract: Frequency of headaches in children is influenced by frequency of headaches in the mother and seems to aggregate in families. Future studies should focus on the determinants of headache aggregation, including genetic and non-genetic factors.

Cited by 33 publications

References 38 publications

In search of risk factors for chronic pain in adolescents: a case–control study of childhood and parental associations

In search of risk factors for chronic pain in adolescents: a case–control study of childhood and parental associations

Offspring of parents with chronic pain

Chronic Daily Headache in Children and Adolescents

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Frequency of Headaches in Children is Influenced by Headache Status in the Mother

Abstract: Frequency of headaches in children is influenced by frequency of headaches in the mother and seems to aggregate in families. Future studies should focus on the determinants of headache aggregation, including genetic and non-genetic factors.

Cited by 33 publications

References 38 publications

In search of risk factors for chronic pain in adolescents: a case&ndash;control study of childhood and parental associations

In search of risk factors for chronic pain in adolescents: a case&ndash;control study of childhood and parental associations

Offspring of parents with chronic pain

Chronic Daily Headache in Children and Adolescents

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Product

Resources

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In search of risk factors for chronic pain in adolescents: a case–control study of childhood and parental associations

In search of risk factors for chronic pain in adolescents: a case–control study of childhood and parental associations