Familial lichen planus. A report of nine cases from four families with a brief review of the literature

Abstract

Nine members of four families, each of whom suffered from lichen planus, are described. The disease appears to differ from the nonfamilial form in its earlier age of onset, tendency to chronicity, increased severity, and the frequent presence of "atypical" disease.

A retrospective and comparative study of familial and non-familial bullous lichen planus

“…This echoes the observation in FLP by others [6,7,11] . Hereditary factors may play a role in BLP, which may be helpful in a full understanding of the etiology and pathogenesis of BLP.…”

“…Copeman et al [11] reported that when LP strikes families, it is more likely to afflict younger members, to erupt more acutely, extensively, and heavily, to attack nails and mucous membranes, and to recur more often. Mahood [7] described 9 members in 4 families and his results suggested that these patients appeared to differ from the non-familial form by their earlier age of onset, tendency to chronicity, increased severity, and the frequent atypical clinical presentations. In a follow-up study of 140 patients with LP diagnosed according to clinical and histologic presentations, Kofoed et al [6] found 15 patients had family history, and familial LP (FLP) was different from non-familial LP by the former occurred more likely in the younger people and had more widespread lesions and a tendency to relapse.…”

“…It is a chronic, inflammatory disease that affects mucosal and cutaneous tissues. Bullous lichen planus (BLP) is a rare variant of LP and has been documented in literature abroad occasionally [2][3][4][5][6][7] , with only a few reports in Chinese literature from 1965 and 2003 [8][9][10] . BLP usually presents sporadically.…”

Superimposed segmental manifestation of polygenic skin disorders

“…29 For heuristic reasons the disorder even has an entry in McKusick's Catalog ''Online Mendelian Inheritance in Man'' (OMIM 151620), 30 although this is certainly a nonmendelian trait with a polygenic background.…”

Familial Bullous Lichen Planus (FBLP): Pedigree Analysis and Clinical Characteristics

“…BLP usually presents sporadically, however, several familial cases have been reported in the literature. Unlike nonbullous familial lichen planus (FLP) that has been well documented in literature, [7][8][9][10][11][12] the clinical features of FBLP have not been described in detail. To provide a more complete understanding of FBLP, we report the clinical presentation of 36 affected individuals from 9 affected families who presented at a tertiary hospital in central China.…”