Familial Bullous Lichen Planus (FBLP): Pedigree Analysis and Clinical Characteristics

Huang, Changzheng; Chen, Siyuan; Liu, Zhixiang; Tao, Juan; Wang, Chunsen; Zhou, Youwen

doi:10.1007/s10227-005-0146-8

Cited by 5 publications

(3 citation statements)

References 12 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A familial form of BLP has been reported in the literature and seems to be associated with younger age of onset, increased severity, and lengthened duration of the disease compared to that of individuals without a similarly affected first- or second-degree relative (Huang et al, 2007). Familial forms may be inherited in an autosomal dominant pattern and display variable penetrance (Huang et al, 2005). …”

Section: Introductionmentioning

confidence: 99%

Update on lichen planus and its clinical variants

Weston

Payette

2015

International Journal of Women's Dermatology

169

179

View full text Add to dashboard Cite

Lichen planus (LP) is an inflammatory skin condition with characteristic clinical and histopathological findings. Classic LP typically presents as pruritic, polygonal, violaceous flat-topped papules and plaques; many variants in morphology and location also exist, including oral, nail, linear, annular, atrophic, hypertrophic, inverse, eruptive, bullous, ulcerative, lichen planus pigmentosus, lichen planopilaris, vulvovaginal, actinic, lichen planus-lupus erythematosus overlap syndrome, and lichen planus pemphigoides. Clinical presentation of the rarer variant lesions may be largely dissimilar to classic LP and therefore difficult to diagnose based solely on clinical examination. However, histopathological examination of LP and LP-variant lesions reveal similar features, aiding in the proper diagnosis of the disease. Management of LP and LP variants aims to control symptoms and to decrease time from onset to resolution; it often involves topical corticosteroids, but varies depending on the severity and location of the lesion. The literature contains an array of reports on the variations in presentation and successful management of LP and its variants. A familiarity with LP and its variants is important in achieving timely recognition and management of the disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Update on lichen planus and its clinical variants

Weston

Payette

2015

International Journal of Women's Dermatology

169

179

View full text Add to dashboard Cite

show abstract

“…The classical sites of predilection are the extremities and the oral cavity.The aetiology of bullous LP is unknown. Familial and drug induced cases have been reported [6,7]. Histopathologically, a subepidermal bulla accompanied by classical changes of LP and negative IF with no immunoglobulin deposition at DEJ differentiate them from the other subepidermal blistering disorders such as LP pemphigoides, epidermolysis bullosa acquisita and porphyria cutanea tarda [8,9].…”

Section: Discussionmentioning

confidence: 97%

PD-1 inhibitors induced bullous lichen planus-like reactions: a rare presentation and report of three cases

et al. 2016

View full text Add to dashboard Cite

The introduction of immunotherapy such as antiprogrammed death1 (anti-PD1) monoclonal antibodies has changed the scenario of treatment in cancer. Apart from their impressive efficacy profiles, they are better tolerated than the anticytotoxic T-lymphocyte-associated protein 4 antibodies. Dermatological adverse events such as pruritus and rash have been reported in various clinical trials. We report three cases of anti-PD1-induced bullous lichen planus (LP)-like reactions encountered in our institution. These patients developed LP-like papules and annular plaques with vesicles or crusted centres. Histology showed LP-like changes with negative immunofluorescence. Vesiculobullous lesions in patients treated with anti-PD1 therapies require a careful clinicopathological evaluation.

show abstract

“…However, familial cases of BLP have also been described in literature. 2 Familial BLP has an earlier onset and more prolonged course compared to non-familial BLP. It tends to affect the same areas as non-familial BLP, mainly lower and upper extremities, trunk and mucosa but it is more frequently associated with nail involvement.…”

Section: Epidemiologymentioning

confidence: 99%

Bullous lichen planus – a review

Liakopoulou¹,

Rallis²

2017

J Dermatol Case Rep

View full text Add to dashboard Cite

Bullous lichen planus is a rare variant of lichen planus. It is characterized by vesicles or bullae, which usually develop in the context of pre-existing LP lesions. It is often misdiagnosed and should be differentiated from other subepidermal bullous diseases especially lichen planus pemphigoides. The diagnosis is based on clinical suspicion and is confirmed by histopathology and immunofluoresence. The clinical features of bullous lichen planus include typical lichen planus lesions, accompanied by the formation of bullae on the affected or perilesional skin. This is evident on histology, with alteration of the dermo-epidermal junction and intrabasal bullae as a consequence of extensive inflammation. The histologic features in conjunction with the negative immunofluoresence indicate that bullous lichen planus is a form of "hyper-reactive lichen planus" rather than a distinct entity. There is no standard treatment of bullous lichen planus. Topical and systemic corticosteroids, dapsone and acitretin have been described as effective choices.

show abstract

Familial Bullous Lichen Planus (FBLP): Pedigree Analysis and Clinical Characteristics

Cited by 5 publications

References 12 publications

Update on lichen planus and its clinical variants

Update on lichen planus and its clinical variants

PD-1 inhibitors induced bullous lichen planus-like reactions: a rare presentation and report of three cases

Bullous lichen planus – a review

Contact Info

Product

Resources

About