Bullous lichen planus – a review

Liakopoulou, Angeliki; Rallis, Εfstathios

doi:10.3315/jdcr.2017.1239

Cited by 25 publications

(33 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The result of this study could have important repercussions not only in the diagnostic phase, but also in the management of the patient with immune-mediated chronic DGs, due the OCT's ability to store and compare images at any time, allowing to monitor treatment and to identify disease relapse before clinical manifestations [24].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Concordance between Optical Coherence Tomography and Histological Investigations for Immune-Mediated Desquamative Gingivitis: Observational Study

Panzarella

Bartolone

Coniglio

et al. 2021

IJERPH

View full text Add to dashboard Cite

Desquamative gingivitis (DG) denotes a heterogeneous immune-mediated disease for which early diagnosis represents a great challenge. The main aim of this study is to validate diagnostic concordance between specific Optical Coherence Tomography (OTC) patterns for DG related to oral Lichen Planus (OLP), Pemphigus Vulgaris (PV), and Mucous Membrane Pemphigoid (MMP) and definitive histological diagnosis. Forty-three patients with suspected immune-mediated DGs, were progressively recruited. Before biopsy, an OCT preliminary evaluation was performed using specific pre-determined OCT diagnostic patterns (i.e., morphology and localization of blisters, status of the basal membrane, epithelial thickness, presence/absence of acantholytic cells into blister and/or inflammatory infiltrate) related to OLP, PV and MMP. After histological confirmation, OCT and histological diagnoses were compared. Using pre-determined patterns, OCT diagnoses of DGs were: 22 (51%) OLP, of which 11 (26%) were with the bullous variant, 4 (9%) PV and 6 (14%) MMP. The same diagnoses were found by histological investigations (with the main OCT discriminatory potential for the bullous variant of OLP). The concordance between the two diagnostic methods was confirmed by the Fisher exact test (p-value < 0.01). These specific OCT patterns show a diagnostic reliability in 100% of the cases investigated, suggesting their accuracy to support the complex diagnosis and management of immune-mediated DGs.

show abstract

Section: Discussionmentioning

confidence: 99%

Diagnostic Concordance between Optical Coherence Tomography and Histological Investigations for Immune-Mediated Desquamative Gingivitis: Observational Study

Panzarella

Bartolone

Coniglio

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…Ultimately, the detection of autoantibodies to the dermal-epidermal junction is central to supporting and securing the diagnosis. In contrast to LPP, the skin changes seen in bullous LP develop in the absence of autoantibodies against structural proteins of the skin, especially COL17 (9). In terms of pathogenesis, given that in the majority of cases of LPP the development of lichenoid skin lesions precedes the formation of blisters, it has been hypothesized that lichenoid inflammation itself may actually promote the development of an autoimmune response, targeting proteins of the epidermal basement membrane (10–14).…”

Section: Definitionmentioning

confidence: 93%

Lichen Planus Pemphigoides: From Lichenoid Inflammation to Autoantibody-Mediated Blistering

2019

View full text Add to dashboard Cite

Lichen planus pemphigoides (LPP) is a very rare autoimmune sub-epidermal blistering disease associated with lichenoid skin changes. Initially thought to be a mere variant of more common inflammatory dermatoses, particularly Bullous Pemphigoid (BP) or Lichen Planus (LP), a growing body of evidence suggests that it is a disease entity in its own right. In common with a range of autoimmune blistering diseases, including BP, pemphigoid gestationis (PG), mucous membrane pemphigoid (MMP) and linear IgA dermatosis (LAD), a key feature of the disease is the development of autoantibodies against type XVII collagen (COL17). However, accurately establishing the diagnosis is dependent on a careful correlation between the clinical, histological and immunological features of the disease. Therefore, we present an up to date summary of the epidemiology and etiopathogenesis of LPP, before illustrating the predisposing and precipitating factors implicated in the development of the disease. In addition to a selective literature search, we compare reports of potential drug-induced cases of LPP with pharmacovigilance data available via OpenVigil. We subsequently outline the cardinal clinical features, important differential diagnoses and current treatment options. We conclude by demonstrating that an improved understanding of LPP may not only lead to the development of novel treatment strategies for the disease itself, but may also shed new light on the pathophysiology of more common and treatment-refractory autoimmune blistering diseases.

show abstract

“…BLP that affects nails appear as hemorrhagic crusty lesions resulting in exposure of nail bed and finally nail atrophy. [8]…”

Section: Discussionmentioning

confidence: 99%

Bullous lichen planus: Case report and review

et al. 2019

View full text Add to dashboard Cite

Lichen planus is a chronic inflammatory mucocutaneous disorder that is seen in skin and oral mucosa. Definitive etiology for oral lichen planus remains unknown. It may or may not be associated with skin lesions. Different clinical patterns such as reticular, plaque, erosive, bullous, and atrophic are seen in oral mucosa of which bullous lichen planus is a rare entity. We present a unique case of bullous lichen planus in a 20-year-old male without skin manifestations along with the review of literature comprising various case reports of bullous lichen planus.

show abstract

Bullous lichen planus – a review

Cited by 25 publications

References 31 publications

Diagnostic Concordance between Optical Coherence Tomography and Histological Investigations for Immune-Mediated Desquamative Gingivitis: Observational Study

Diagnostic Concordance between Optical Coherence Tomography and Histological Investigations for Immune-Mediated Desquamative Gingivitis: Observational Study

Lichen Planus Pemphigoides: From Lichenoid Inflammation to Autoantibody-Mediated Blistering

Bullous lichen planus: Case report and review

Contact Info

Product

Resources

About