Familial Lichen Planus

Mahood, John M.

doi:10.1001/archderm.1983.01650280020008

Cited by 49 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sunlight does appear to be the precipitating factor, and lesions have been provoked experimentally with UVB (Isaacson et al, 1981, Salman et al_ 1989 (Fig, 10). Lesions may be isolated or multiple and become confluent, covering the entire anterior tibial area This variant is quite common among patients with familial LP (Mahood, 1983).…”

Section: Ungual Lpmentioning

confidence: 99%

“…The clinical differentiation from LP may be very difficult (Copeman et ul, 1979). Familial LP develops in members of the same family and is seen especially among sisters (Mahood, 1983, Lin et al 1986. This form of LP may become generalized, relapses are frequent, and, in about 40% of cases, lesions appear before the age of 20 (Mahood, 1983) Other forms include rare patterns such as pigmentosus, linear, exfoliative, guttate, and zosteriform LP (Fellner, 1980;Harder and Kasha, 1990) Koebnerization is a common occurrence in LP, especially in areas previously subjected to trauma such as burns, friction, wounds, or UV light (Fig.…”

Section: Vesiculobullous Lpmentioning

confidence: 99%

See 1 more Smart Citation

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

470

461

View full text Add to dashboard Cite

Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

show abstract

Section: Ungual Lpmentioning

confidence: 99%

Section: Vesiculobullous Lpmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

470

461

View full text Add to dashboard Cite

show abstract

“…In two other studies, however. HLA B7 was present in only 4 of 8 patients from 4 different fami lies [10] and in none of 5 patients from the same family [ …”

Section: Discussionmentioning

confidence: 99%

“…It is usually a disease of early onset; median age of 26 years versus 46 years [3]. It is more often of the generalized type with involvement of the mucosa oris with tendency for erosive, ulcerative, linear and atypical forms [10] with long duration of the disease and more frequent relapses [3,10].…”

Section: -mentioning

confidence: 99%

Familial Lichen planus

Katzenelson

Lotem²,

Sandbank³

1990

Dermatology

View full text Add to dashboard Cite

Familial lichen planus (FLP) was observed to have developed within a period of 3 years in 2 sisters as well as in the son of one of the women. In contrast to typical FLP, the eruption was generalized in only 1 of these patients; no atypical forms were observed; the response to topical treatment with steroids was rapid, and the relapses were few and mild. Previous reports of familial cases of lichen planus as well as the long interval between onset of the disease in the affected members of the family speak in favor of a genetic predisposition. HLA typing revealed HLA DR in all 3 patients. There was no increased incidence of HLA B7, HLA A3 or HLA A28.

show abstract

“…Although lichen planus is a fairly common disorder, its familial occurrence is uncommon and varies between 1.5 and 10.7% (1,2). In most familial reports, only two or three members of the family (3,4) have had the disease; occasionally more family members may be affected (5,6). We recently came across two patients in the pediatric dermatology clinic with a positive family history of lichen planus (LP).…”

mentioning

confidence: 99%