Familial Lichen Planus

Sandhu, Kamaldeep; Handa, Sanjeev; Kanwar, Amrinder J.

doi:10.1046/j.1525-1470.2003.20221_5.x

Cited by 18 publications

(12 citation statements)

References 10 publications

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“…A family history of LP was found in only 2 patients (0,72%) out of the total of 274. Nevertheless, it is important that medical notes show the presence of a family member with the same disease, as genetic predisposition is thought to be one element involved in OLP’s etiopathogenesis (38).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous, genital and oral lichen planus: A descriptive study of 274 patients

Cassol-Spanemberg

Carrión²,

Rivera-Campillo³

et al. 2018

Med Oral

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BackgroundLichen planus (LP) is a chronic autoimmune disease that affects the oral mucosa as well as the skin, genital mucosa and other sites. Objective: to evaluate the correlation between oral, genital and cutaneous lichen planus, in a sample of LP patients.Material and MethodsThis descriptive study reviewed 274 clinical histories of patients, who all presented histological confirmation of lichen planus verified by a pathologist, attending research centers in Barcelona.ResultsA total of 40 LP patients (14.59%) presented genital lesions. Of 131 patients with cutaneous LP (47.8%), the most commonly affected zones were the body’s flexor surfaces, representing 60.1% of cases. 24% of patients (n=55) related the start of the lesions with previous stress events. Of the 131 subjects with cutaneous lesions, 19% (n=25) also presented oral lichen planus (OLP). Of the total sample, 53.6% (n=147) of patients presented oral lesions. The systemic diseases most commonly associated with this patient sample were psychological problems such as stress, anxiety and depression (48%), hypertension (27%), gastric problems (12%), and diabetes (9.7%). A family history of lichen planus was found in only 2 cases (0,72%) out of the total of 274.ConclusionsAny patient with OLP should undergo a thorough history and examination to investigate potential extraoral manifestations. The fact that 37 patients with OLP in this patient series were identified with simultaneous involvement at more than one site highlights the need for thorough evaluation and multidisciplinary approaches to this disease. Key words:Oral lichen planus, extra-oral manifestations, cutaneous lichen planus, genital lichen planus.

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Section: Discussionmentioning

confidence: 99%

Cutaneous, genital and oral lichen planus: A descriptive study of 274 patients

Cassol-Spanemberg

Carrión²,

Rivera-Campillo³

et al. 2018

Med Oral

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“…-Antecedentes familiares: Indagaremos sobre la presencia en la familia de algún miembro con la misma enfermedad, ya que la predisposición genética se considera un elemento implicado en la etiopatogenia del LPO (15)(16)(17). -Antecedentes personales del paciente: Debemos averiguar si el paciente está tomando algún tipo de medicación o si padece alguna enfermedad general que pueda influir en el curso de la enfermedad (diabetes) o enfermedades con la misma base inmunológica (hepatopatías crónicas, lupus, colitis ulcerosa, síndrome de Sjögren, etc.).…”

Section: Historia Clínica Anamnesisunclassified

“…En primer lugar, existe una predisposición genética. La presencia de diferentes antígenos de histocompatibilidad (HLA) y la afectación de varios miembros de una misma familia así lo confirma (15)(16)(17).…”

Section: Introductionunclassified

Diagnóstico del liquen plano oral

Carrión¹,

Rey

Mallón

et al. 2008

Av Odontoestomatol

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El objetivo de este trabajo es presentar los aspectos clínicos y patológicos necesarios para conocer mejor el liquen plano oral y poder diagnosticarlo correctamente. El diagnóstico se obtiene en primer lugar por el aspecto clínico de las lesiones. Se debe realizar siempre biopsia y estudio anatomopatológico para confirmar la sospecha clínica y realizar diagnóstico diferencial con otras entidades de apariencia clínica similar. Los pasos que debemos seguir para realizar un diagnóstico de certeza son: estudio de la clínica (anamnesis y exploración clínica), biopsia para estudio histopatológico y analítica sanguínea y determinación de la tensión arterial, buscando una posible relación con determinados procesos sistémicos. Se hará una inmunofluorescencia directa cuando haya que diferenciarlo de dermatopatías similares (lupus, penfigoide o pénfigo). En ocasiones podremos realizar un análisis estructural y otras pruebas diagnósticas. Palabras clave: Mucosa oral, diagnóstico oral, liquen plano oral.

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“…Familial cases of LP have been reported among children, mostly the oral or bullous types. In most familial LP case reports, only two or three members of the family have had the disease; occasionally, more family members may be affected 7 . Familial cases are known to have an early onset of disease.…”

mentioning

confidence: 99%

“…In most familial LP case reports, only two or three members of the family have had the disease; occasionally, more family members may be affected. 7 Familial cases are known to have an early onset of disease. It is more common in children and young adults, more often a generalized type, with involvement of the oral mucosa, and tends to run a longer course, with more frequent involvement of nails and more frequent relapses.…”

mentioning

confidence: 99%