Familial Aggregation of Uterine Myomas in Japanese Women.

Abstract

To assess the familial aggregation of uterine myomas in Japanese women with myomas, one hundred forty four women requiring surgery for myomas and 288 age-matched healthy controls were studied in Hokkaido, Japan. The incidence of positive first-degree family history of myoma: among women aged 45-54 years with myomas was greater than that among controls (31.5 % versus 15.2%, respectively, p < 0.01). Analyses categorized by the status of parity and familialit) among subjects showed that the risk for myomas was the greatest in women who had both fewe births (parity = 0 or 1) and the positive family history of myomas as compared with those who hac both more births (parity ? 2) and the negative familiality of myomas (odds ratio = 5.8, 95% confidence interval = 2.3 -14.

Epidemiology of Myomas

“…Although not specifically addressing the population prevalence of disease, a Japanese study [8] examined the prevalence of fibroid disease in first-degree relatives of women undergoing surgery for fibroids. Thirty-one percent of women undergoing fibroid surgery reported a first degree relative with fibroids, as opposed to 15% of controls.…”

“…A small sample of patients who had their fibroids followed-up ultrasonographically [20] saw an average growth of 1.2 cm in 2.5 years. The chance of being diagnosed with fibroids increases with age until about 50 years and then declines sharply [8,11].…”

A High Concentration of Genistein Induces Cell Death in Human Uterine Leiomyoma Cells by Autophagy

“…These tumors clinically affect approximately 25% of all women in the United States, with African American women having a higher risk of development of fibroids compared to Caucasian women [3]. Uterine fibroids are also prevalent worldwide affecting women in Europe [4], Africa [5], Asia [6] and South America [7]. Fibroids can be asymptomatic or symptomatic depending on the tumor size and location in the uterus, with common symptoms such as menorrhagia and pelvic pressure.…”

Fibroid in Pregnancy- Associated Factors

“…This study showed significant association of family history of fibroids in sister while not in mother. A Japanese study also showed increased risk of fibroids in women with history of fibroids in first degree relatives of 31.5% versus 15.2% in controls 8 .VanVoorhis et al found maternal history to be a significant risk factor 9 . Recent cytogenetic and genetic studies have shed some light on the etiology of fibroids.…”