Epidemiology of Myomas

Payson, M.; Leppert, Phyllis C.; Segars, James H.

doi:10.1016/j.ogc.2005.12.004

Cited by 119 publications

(85 citation statements)

References 36 publications

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“…The prevalence of uterine fibroids approaches to 33% of women of reproductive age based on clinical assessment, and up to 50% on ultrasound scans. This disorder presents in 5% -10% of women with infertility (Payson et al 2006;Revel 2012).…”

Section: Hox Genes and Leiomyomamentioning

confidence: 99%

The Role ofHoxGenes in Female Reproductive Tract Development, Adult Function, and Fertility

Taylor

2015

Cold Spring Harb Perspect Med

196

158

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HOX genes convey positional identity that leads to the proper partitioning and adult identity of the female reproductive track. Abnormalities in reproductive tract development can be caused by HOX gene mutations or altered HOX gene expression. Diethylstilbestrol (DES) and other endocrine disruptors cause Mü llerian defects by changing HOX gene expression. HOX genes are also essential regulators of adult endometrial development. Regulated HOXA10 and HOXA11 expression is necessary for endometrial receptivity; decreased HOXA10 or HOXA11 expression leads to decreased implantation rates. Alternation of HOXA10 and HOXA11 expression has been identified as a mechanism of the decreased implantation associated with endometriosis, polycystic ovarian syndrome, leiomyoma, polyps, adenomyosis, and hydrosalpinx. Alteration of HOX gene expression causes both uterine developmental abnormalities and impaired adult endometrial development that prevent implantation and lead to female infertility.

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Section: Hox Genes and Leiomyomamentioning

confidence: 99%

The Role ofHoxGenes in Female Reproductive Tract Development, Adult Function, and Fertility

Taylor

2015

Cold Spring Harb Perspect Med

196

158

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“…Fibroids represent a tremendous public health burden on women and economic cost on society. 2 There is a definite correlation between estrogen and fibroids noting their absence before puberty and their regression after menopause and enlargement with years of greatest ovarian activity. 3 There is a definite close association between hyperestrogenism and fibromyoma.…”

Section: Introductionmentioning

confidence: 99%

A study of menstrual disturbance in cases of fibroid uterus

Khyade

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Leiomyoma’s also called fibroids due to their abundant fibrotic tissue have a 70-80% cumulative incidence in childbearing years. Fibroids are the most common occurring benign tumors. Fibroids represent a tremendous public health burden on women and economic cost on society.Methods: It is prospective study done over a period of one year, 50 cases presenting to the obstetrics and gynecology department. Women included were in their reproductive age between 30-55 yrs. of age and had experienced menstrual bleeding complaints.Results: The prevalence of uterine fibroids ranged from 46% in age group 41-45yrs, 24% in 46-50yrs, and 11% in 36-40yrs. Women with uterine fibroids complained of menorrhagia in 78%, dysmenorrhea in 30%, metrorrhagia in 10%, polymenorrhea 22%, pain in abdomen 22%, urinary problem 8%, SCOPV 6%, primary infertile 4%, leucorrhea 12% and lump in abdomen 4%.Conclusions: Uterine fibroid is a common problem in women of reproductive age causing various bleeding and pain symptoms that can have negative impact on various aspects of women’s life.

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“…(6,7) Based on location,they have been classified as submucosal, intramural, subserosal leiomyoma. They were noted clinically in 20-30% of women over 30 years of age.…”

Section: Discussion:-mentioning

confidence: 99%